Lecture 15

Question 1

direct drug effects, drug induced pulmonary disease

Answer 1

present as an idiosyncratic reaction or direct pulmonary toxicity from a drug or its metabolites

Question 2

DIPD symptoms

Answer 2

pleuritic chest pain
dyspnea
cough
wheezing
fever

Question 3

three kinds of DIPD

Answer 3

reactions involving the interstitium

reactions involving the pleura
reactions without direct effects to the lunt

Question 4

reactions involving the interstitium disease classifications

Answer 4

interstitial pneumonitis and fibrosis
organizing pneumonia
eosinophilic pneumonia
hypersensitivity pneumonitis
non cardiac pulmonary edema
diffuse alveolar damage

Question 5

reactions involving the pleura disease classification

Answer 5

nonlupus-related pleural effusion
lupus-related pleural effusion

Question 6

reactions without direct effects to the lung reaction

Answer 6

bronchospasm
cough
pulmonary arterial hypertension
thromboembolic disorders
apnea
chest wall rigidity

Question 7

which scale is used to see if there is a DIPD

Answer 7

Naranjo ADR Probability scale

Question 8

rating for Naranjo

Answer 8

> 9 is probable
5-8 = probable
possible = 1-4
doubtful is less than/equal to -0

Question 9

what is a medication class that causes cough

Answer 9

ACE inhibitors

Question 10

which meds cause bronchospasm

Answer 10

acetaminophen, ASA, NSAIDS, beta blockers

Question 11

What do we assess

Answer 11

assess for likelihood of drug induced adverse reaction including:
- history of exposure to the drug
- timing of the drug exposure
- clinical findings - imaging
- exclusion of other causes
- drug discontinuation, improvement after discontinuation?