Lecture 23 Flashcards
how does mRNa based vaccinations work
mrna injected directly into the cytoplasm of host, it has to be contianed in a lipid bilayer, stabilized by nanoparticles.
once mrna is in the cytoplasm, it gets translated into a protein and travels to the outer surface of host cell where it is recognized as foreign, stimulates immune system
Pfizer was how efficaceous
95%
moderna VE
94%
AZ VE
70
Novovax VE
90
side effects are more common in
younger individuals, 2nd dose
three things that causes coronavirus mutations
zoonotic sources and animal reservoirs
immune escape from monotherapy
accelerated evolution in persistent infection
NACI Rec 1
at least one covid 19 vaccine should be offered to individuals 6mo and older
does hybrid immunity protect from infection better
compared with protection from infection alone or vaccination alone, hybrid immunity is better
MI infection happens in
males over females
second dose vs first dose
ages 12-17
more with moderna than pfizer
increased risk of GBS in which vaccine
janssen, 21 times higher
