CV 3 Flashcards
What is blood pressure
Cardiac output x total peripheral resistance
what is cardiac output
heart rate x stroke volume
what is total peripheral resistance
resistance in blood flo win the arterioles
the ability of pacemaker cells to spontaneously depolarize is determined by what
Pacemaker current (Ir) carried by slow Na influx through the HCN channel. It is an inward current, responsible for starting the depolarization phase.
How does HCN work
cAMP binds to HCN channel, allowing Na+ influx
Which hormones increase cAMP
NE - increase heart rate
which hormones decrease cAMP
Acetylcholine - decrease heart rate
what is stroke volume
end diastolic volume - end systolic volume
what is preload
the degree to which ventricles are stretched. Represends ventricular end diastolic volume
the more stretch of muscle fibers, the..
greater force in contraction
contractility
the intrinsic ability of the heart to contract dependent on the amount of Ca and the binding between actin and myosin