Lecture 22

Question 1

viral phase

Answer 1

viral entry via ACE2 recepors

Question 2

host immune response

Answer 2

macrophages, dendritic cells, cytotoxic T cells, pronflammatory cytokine and chemokine

Question 3

hyperinflammatory phase

Answer 3

excessive inflammation, cytokine storm, leads to organ failure

Question 4

two ways to test covid

Answer 4

PCR, RAT

Question 5

severe covid disease definition

Answer 5

oxygenation status less than 94% on room air

Question 6

CEV group 1

Answer 6

severely immunocompromised

Question 7

CEV Group 2

Answer 7

Moderately immunocompromised

Question 8

CEV group 3

Answer 8

high risk for hospitalization and death but not immunocompromised

Question 9

First line agent for mild/mod disease

Answer 9

nirmatrelvir/ritonavir = antiviral = paxlovid

Dose is nirm 150mg (2 tabs) and rit (100mg) PO BID , take within 5 days of symptom onset

Question 10

other covid mild/mod therapy

Answer 10

sotrovimab
dosed IV x 1 dose

Question 11

Remdesivir MOA plus dose

Answer 11

inhibits viral replication, dose is 200mg IV loading dose, then 100mg IV daily x 2 days

Question 12

first line, alt, last line

Answer 12

pax, remdesivir, mabs

Question 13

severe covid treatment

Answer 13

dexamethasone, Tocilizumab, baricitinib

Question 14

severe dexamethasone dosing

Answer 14

6mg IV q 24h for up to 10 days

Question 15

tocilizumab dosing

Answer 15

400mg IV one dose

Question 16

is remdesivir recommended in severe covid

Answer 16

no