Lecture 5 Flashcards
Chapter 3
what are the 2 types of nervous systems
central nervous system (CNS) and peripheral nervous system (PNS)
what does the Central nervous system (CNS)
include
Everything in the brain and spinal cord
what does the Peripheral nervous system (PNS)
include
Any part of the nervous system outside the brain and spinal cord, including the nerves attached to the brain and spinal cord
what is the distinction between
the cns and pns
In the central nervous system, myelin is created by Oligodendrocytes
In the peripheral nervous system, myelin is created by Schwann cells.
what is Interstitial fluid
basically synonymous with extracellular fluid. It is the fluid that surrounds cells in the body.
The interstitial fluid for cells outside of the CNS comes directly from what
blood
The interstitial fluid for cells outside of the CNS comes directly from blood.
In brief how does it work
The liquid (fluid) component of blood is called blood plasma. Blood plasma can leak out of small holes, gaps in the blood vessels (blood capillaries), at which point it is called lymph.
what is The lymphatic system and how does it work
Lymph is the interstitial fluid for all cells in the body outside of the CNS.
It flows around the cells of the body picking up waste and bacteria.
Lymph is collected into lymph vessels and taken to lymph nodes/organs, which detect and destroy invading organisms and foreign particles.
Eventually lymph is returned to the circulatory system (the blood stream).
does the CNS participate in the lymphatic system
The CNS is a protected space. It does not participate in the lymphatic system
what is the Blood–brain barrier
Semipermeable barrier between the blood and the brain
if the brain needs something it will actively pull it in
do The blood capillaries that flow through the CNS have gaps in them
no gaps in them
The blood capillaries that flow through the CNS have no gaps in them.
This feature is known as what
the blood brain barrier.
Instead of using lymph (which is anything that leaks out of blood vessels), the CNS makes its own interstitial fluid called what
cerebrospinal fluid (CSF).
what is cerebrospinal fluid (CSF).
made of
It is made fresh from stuff in the blood
Cerebrospinal fluid (CSF) flows around the cells of the body doing what
picking up waste and bacteria. This fluid eventually returned to the blood.
what is the glymphatic system
The blood capillaries that flow through the CNS have no gaps in them.
This feature is known as the blood brain barrier.
Instead of using lymph (which is anything that leaks out of blood vessels), the CNS makes its own interstitial fluid called cerebrospinal fluid (CSF).
It is made fresh from stuff in the blood.
Cerebrospinal fluid (CSF) flows around the cells of the body picking up waste and bacteria. This fluid eventually returned to the blood.
This process is known as the glymphatic system.
CSF is produced in the ventricles of the brain in tissue called what
choroid plexus
CSF is produced in the ventricles of the brain in tissue called the choroid plexus.
The ventricles are connected how
interconnected hollow spaces filled with CSF.
in THE VENTRICULAR SYSTEM OF THE BRAIN how many ventricles are there
4 ventricles
what are the 4 ventricles in the THE VENTRICULAR SYSTEM OF THE BRAIN
The first two, the lateral ventricles are the largest. They sit underneath the cerebrum.
The third ventricle lies between the two thalamic nuclei.
The fourth ventricle sits between the pons and cerebellum.
how often is CSF made
CSF is made continuously and it is half replaced every three hours (the half-life).
what is The cerebral aqueduct
is a long, tube like structure that connects the third and fourth ventricle.
CSF exits the ventricles and flows around the brain and spinal cord (in the subarachnoid space) before it is absorbed into the blood supply.
what are meninges
tough, protective connective tissues that surround the brain.
what are the 3 types of meninges
The dura mater
The arachnoid membrane
The third layer that sits closest to the brain is pia mater.
what is dura mater
is the outer layer. It is thick, tough, unstretchable tissue.
what is arachnoid membrane
is the middle layer. It is soft and spongy and has a web-like appearance.
what is pia mater
The third layer that sits closest to the brain is pia mater. This layer and the space above it has blood vessels in it.
what is subarachnoid space
between the arachnoid membrane and pia mater
The subarachnoid space (between the arachnoid membrane and pia mater) is filled with what
cerebrospinal fluid (CSF).
A hollow, enclosed neural tube forms during when (the brain)
the first month of development in the womb.
A hollow, enclosed neural tube forms during the first month of development in the womb. The stem cells that make up this neural tube are called what
neural progenitor cells
Neural progenitor cells divide and multiply during the first two months of development, during a period known as what
symmetrical cell division.
At around the 2 month mark (in human gestation), symmetrical division ends and asymmetrical division starts what is this
which is when the first glial cells (radial glia) and neurons are born.
what are the 5 major divisions of the brain
forebrain: Telecephalon and diencephalon
Midbrain: Mesencephalon
Hindbrain: Metecephalon and Myelencephalon
what are the categories of Brain Development
Symmetrical Division
and asymmetrical Division
Neurogenesis
Apoptosis
what is Symmetrical Division
Division of a neural progenitor cell that gives rise to two identical progenitor cells
when does Symmetrical Division happen
Symmetrical cell division of neural progenitors cells occurs during the first two months of development in the womb. Symmetrical division ends when asymmetrical division starts. Neural progenitor cells hug the inside ring of the neural tube in an area called the ventricular zone
what is Asymmetrical Division
Division of a neural progenitor cell that gives rise to another progenitor cell and a new glial cell or new neuron
when does Asymmetrical Division
happen
In nervous system development, the period of asymmetrical division that gives birth to all the neurons in the brain lasts for about 2 to 3 months. More neurons are born during this time than will be present at birth.
what is Neurogenesis
Production of new neurons
when does Neurogenesis happen
Neurons are born from the asymmetrical cell division of neural progenitor cells (stem cells). Most neurogenesis stops 4 to 5 months into development, however the adult brain retains some stem cells that continue to divide and produce neurons throughout life, particularly in the hippocampus
what is Apoptosis
a process of programmed cell death that occurs I multicellular organisms
when does Apoptosis
happen
a highly regulated and controlled form of cell suicide that ensures that the contents of a dying cell do not disrupt its neighbours. The process of asymmetrical cell division that supports neurogenesis in the developing brain ends when neural progenitor cells undergo apoptosis
what are the ANATOMICAL DIRECTIONS
Neuraxis Anterior (rostral) Posterior (caudal) Dorsal (superior; Ventral (inferior; Lateral (distal, Medial (proximal,
what is Neuraxis
An imaginary line that runs along the length of the CNS
what is Anterior (rostral)
Front end or toward the head
what is Posterior (caudal)
Tail end
what is Dorsal (superior)
Top of the head and towards the back
what is Ventral (inferior
towards the belly)
Front surface that faces the ground
what is Lateral (distal
away from the midline) Toward the side
what is Medial (proximal
close to the midline)
Toward the middle
what is Sagittal plane
A mid-sagittal cut means the exact middle (between the eyes)
what is Medial
toward midline
what is Lateral (
away from midline)
what is Transverse plane
(frontal section, cross section, coronal section)
like a cut dividing front of brain and back of brain