Lecture 5 Flashcards
What types of cells are in cellular innate immunity?
-Neutrophils
-Monocytes and macrophages
-Natural killer cells
-Dendritic cells
Which cellular innate cells phagocytize and destroy pathogens?
-Neutrophils
-Macrophages
How do we recognize pathogens?
We recognize antigens and epitopes
-antigen binds to antibody receptors–>molecule recognized by immune system
-epitope–>short sequence of antigen
How do we know what is self and non self?
MHC
-present epitopes from inside the cell to cell surface for detection
Which MHC class is presented in all nucleated cells
and presents peptides from inside the cytosol
window inside of the cell
MHC class I
Which MHC class is only in specialized immune cells
and processes peptides from extracellular space
mirror outside of the cell
MHC class II
What do natural killer cells do?
Kill cells without MHC I presentation
What is the advantage to causing apoptosis rather than simply lysing the cell?
-Apoptosis contains virus particels in a controlled manner–>prevents it from infecting other cells
-Lysis would release contents to other cells
Which cell is professional
-present both MHC I and MHC II
-bridges innate and adaptive
Dendritic cells
What are the 2 cells that make up the adaptive immunity?
B cells and T cells
B cells
-come from bone marrow
-secrete antibodies for specific antigens
-activated by antigens binding to B cell receptor
T cells
-come from thymus
-activated by antigen binding to T cell receptor
-become CD4 helper T cells or CD8 killer T cells
How do B and T cells recognize so many different kinds of antigens?
Diversity in their variable regions
-rearrangements and mutations in variable regions makes them diverse
What is one type of professional antigen presenting cell?
Dendritic cells
T cells can proliferate and differentiate into what kind of cells and what is their function?
-CD4 helper T cells
-CD8 killer T cells
