Lecture 36/37/38 Epidemiology Flashcards

1
Q

Epidemiology

A

the study of the occurrence, distribution, and determinants of health and disease in a population and the application of this study in the control of health problems

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2
Q

What do epidemiologists do?

A

trace the spread of disease to identify its origin and mode of transmission

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3
Q

What types of data do epidemiologists collect on populations?

A

demographics, symptoms, history, animal vector data, medical records, etc

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4
Q

When did epidemiology start?

A

mid-1880s

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5
Q

Ignaz Semmelweis

A

“Savior of Mothers”; implemented handwashing wtih chlorinated lime solutions

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6
Q

Florence Nightingale

A

nurse and statistician; sent to Ukraine to report conditions of infection during the war

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7
Q

John Snow

A

“Father of Epidemiology”; british physician in the 1850s that pioneered epidemiological investigations and disease mapping

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8
Q

Why were Nightingale’s Rose diagrams significant?

A

provided a visual that was easier to understand than charts

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9
Q

Epidemic

A

when as disease occurs in an unusually high number of individuals in a population at the same time

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10
Q

What did John Snow do in the 1850s?

A

traced the source of an outbreak of Cholera to a water pump on Broad St.

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11
Q

Where there other people investigating this cholera outbreak at the same time?

A

Yes; for example, Edmund Cooper and the British Empire

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12
Q

Endemic

A

normal rates of disease that is expected in a population

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13
Q

Endemic Disease

A

constantly present, occurs at a steady low frequency with predictable changes

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14
Q

Epidemic Disease

A

sudden increase in occurrence of disease above expencted levels

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15
Q

Example of an endemic disease

A

the common cold

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16
Q

Example of an epidemic disease

A

cholera

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17
Q

Pandemic disease

A

increase in a disease through large populations and across continents

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18
Q

Example of a pandemic disease

A

plague, AIDS, covid-19

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19
Q

Significance of understanding the chain of infection

A

helps us develop strategies to prevent further infection and to control disease

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20
Q

What is the chain of infection?

A

1) the pathogen
2) source of pathogen
3) transmission to host
4) susceptibility of the host
5) exit from host

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21
Q

Etiological agent

A

the organisms that causes disease

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22
Q

What do you use to identify the etiological agent?

A

Kock’s postualtes

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23
Q

Examples of biological agents of disease

A

metazoans, protozoans, fungi, bacteria, viruses, prions

24
Q

Reserviours

A

the site or natural environment where the pathogen is normally found living and from which infection can occur

25
Q

What are the two types of human reservoirs?

A

acute clinical cases and carriers

26
Q

Incubatory carriers

A

just get sick and recover

27
Q

Convalescent carriers

A

recover but still shed disease

28
Q

Chronic carriers

A

sick and shed disease

29
Q

Asymptomatic

A

no symptoms and shed disease

30
Q

True or False: there are many kinds of animal reservoirs

A

True!

31
Q

Zoonotic infection

A

infectious disease originating from animals, can be transmitted from one type of animal to another and may be transmitted to humans

32
Q

Examples of zoonotic infection

A

plague, rabies, west nile, monkeypox

33
Q

Examples of environmental reservoirs

A

plants, soil, watr

34
Q

Can you easily get rid of pathogens in environmental reserviours?

A

No!

35
Q

Direct transmission

A

an infectious agent is transferred from a reservoir to a susceptible host by direct contact or droplet spread

36
Q

Indirect transmission

A

the transfer of an infectious agent from reservoir to a host by suspended air particles, inanimate objects, or animate intermediaries

37
Q

What are animate intermediaries called?

A

vectors

38
Q

What are inanimate objects called?

A

vehicles

39
Q

What four things impact host susceptibility?

A

1) genetic factors
2) general resistance factors
3) specific acquired immunity
4) host variability (timing)

40
Q

What are five things that impact host variability?

A

1) nutrition
2) stress levels
3) physical damage to tissue
4) behavioral differences
5) environmental conditions

41
Q

What are some ways in which a pathogen can exit from a host?

A

coughing, insect bite, removal of blood, skin cells, urine, feces

42
Q

What are the Cholera Stages of Disease?

A

1) incubation period
2) prodromal period
3) period of illness
4) period of decline
5) period of convalescence

43
Q

Incubation period

A

no signs or symptoms; few hours to few days

44
Q

Prodromal period

A

mild signs/symptoms; 1-2 days if any

45
Q

Period of illness

A

disease most severe; symptoms of diarrhea, nausea, vomiting

46
Q

Period of decline

A

signs and symptoms subside; decreased diarrhea; begin response to rehydration therapy and antibiotic treatment

47
Q

Period of convalescence

A

person regains strengths and the body returns to normal; some people can become reservoirs of disease for months or even years

48
Q

Who is most at risk of contracting cholera?

A

those who do not have access to piped safe water and adequate and proper sanitation

49
Q

Period of communicabiltiy

A

the time in which an infectious disease might be transferred

50
Q

What is the period of communicability for cholera?

A

the duration of the stool-positive stage; can persist for several months

51
Q

Infective dose

A

the number of pathogens required to infect a host

52
Q

Index/primary case

A

the person who first gets the disease in a population

53
Q

Common sources for infection of cholera?

A

contaminated water, contaminated foods, vegetables fertilized with human excreta, soiled hands, fish/shellfish eaten raw

54
Q

Herd immunity

A

immunity in some individuals from vaccinations or naturally acquired can protect non-immune individuals from infection

55
Q

Host variability factors for cholera

A

1) poor sanitary conditions
2) raw or undercooked shellfish
3) reduced or nonexistent stomach acid
4) household exposure
5) type O blood

56
Q

What are three epidemic control measures for cholera in Haiti?

A

1) proper sanitation
2) sterilization of waste
3) quarantine
4) destruction of domestic animal reservoirs
5) immunization
6) public health education
7) increased accessibility to treatment