Lecture 32 - Skin

Question 1

Urticaria?

Answer 1

unstable mast cells in dermis, multiple causes e.g. allergy, drugs, cold), autoimmune version where antibodies bind and degranulate

Question 2

Dermo-epidermal junction?

Answer 2

herni desmosomes anchor epidermis to dermis

Question 3

Bullous pemphigoid?

Answer 3

autoimmune, formation of antibodies against hemi desmosomal proteins, neural skin and muscular forms of antigen, impaired BBB lead to antibody production

Question 4

Pemphigus vulgaris?

Answer 4

IgG antibodies attacking keratinocytes desmosome -> superficial and oral erosions

Question 5

Colourful screening tool?

Answer 5

direct immunoflourescence - shows intradermal IgG deposition in pemphigus (chicken hook) and linear light up in bullous

Question 6

Atopic excema?

Answer 6

inhibited conversion of profilggarin into filggarin due to mutation -> decreaed natural moisturising factor

Question 7

Allergic contact dermatitis?

Answer 7

hx of atopic dermatitis more susceptible due to defects in epidermal barrier, patch test helps identify antigen for prevention

Question 8

Reasons patients are immunosuppressed?

Answer 8

treat severe disease, result of disease, organ transplant

Question 9

Diagnositc tools n skin disease/

Answer 9

swab culture (bacteria and virus), skin biopsy, blood culture

Question 10

Painful rash?

Answer 10

disseminated varicellar zoster virus, treated w aciclover

Question 11

Squamous cell cancer epidemiology?

Answer 11

immune suppressed have reduced repair of UV damage -> squamous cell carcinoma in cells highly exposed to the sun