Lecture 18 - Blood and Blood Products Flashcards
Blood component?
blood product manufactured by local blood centre derived from single or multiple donations, contains all products, WBC removed, blood group identified
Plasma derivative?
product from large pool of plasma donations (1000) using industrial systems
Maintaining a safe blood supply?
use of voluntary non-incentivised donors, refusal of donors whose behaviour or lifestyle places them at increased risk of acquiring recognised blood born infections, testing for major viruses, destruction of pathogens
Selection of Donors?
between 16-70, good general health, able to donate every 12 weeks, health questionnaire and Hb check
Tests of blood donations?
ABO, RhD and antibody, Hep B, Heb C, HIV, HTLV, syphilis
Blood processing?
blood centrifuged, plasma transfereed (w or wout platelets), preservative solution added to blood to promote flow, platelet concentrate and fresh frozen plasma separated
Blood components - red cells?
2-6 degrees C, 35 day shelf life, used to improve oxygen delivery to tissues in case of anaemia or blood loss
Blood components - platelet concentrate?
20-24 degrees C, 7 day shelf life, management or prevention of bleeding in patients w low platelet count\
Blood components - fresh frozen plasma?
minues 25 degree C, 2 year shelf life, correction of abnormal coagulation in patients who are bleeding
Prescribing checklist for transfusion?
aim, can i minimise blood loss, other treatment options, specific clinical indication, benefits > risks
Considerations for red cell transfusion?
signs and symptoms of hypoxia (CARDIOPULMONARY RESERVE), ongoing blood loss, anaemia risk, transfusion risks, artherosclerotic disease
Indications for platelet transfusion?
bone marrow failure, surgery, platelet function disorder, excessive bleeding, massive haemmorrhage/transfusion
Indications for FFP?
immediate reversal of warfarin, treating multiple coagulation deficiencies associated w DIC
