Lecture 29 Clinical Pathological Conference of the Ovary

Question 1

Where do most cases of ovarian cancer originate from

Answer 1

Fallopian tube

Question 2

Name risk 2 risk factors of ovarian cancer

Answer 2

Genetic: HNPCC, BRCA1 and 2

Incessant ovulation

Question 3

Molecular alterations P53, BRCA1,2 ovarian cancer origin is___

Answer 3

Fimbriae of Fallopian tube

Question 4

Molecular alterations ARID1A, PIK3CA and PtEN ovarian cancer origin is___

Answer 4

Through endometriosis which becomes endometrial cancer and clear cell carcinoma

Question 5

What are ovarian cancer symptoms

Answer 5

Vague
Indigestion/early satiety/poor appetite 
Altered bowel habit/pain
Bloating discomfort/weight gain
Pelvic mass (pressure symptoms/asymptomatic)

Question 6

How is ovarian cancer diagnosed

Answer 6

USS abdomen and pelvis
CT scan- chest, abdomen and pelvis
CA 125
Surgery

Question 7

What US features are seen in ovarian cancer

Answer 7

Multi-lobular
Bilateral
Asites

Question 8

Stage 1 Ovarian Cancer

Answer 8

Limited to ovaries with capsule intact

Question 9

Stage 2 Ovarian Cancer

Answer 9

One or both ovaries with pelvic extension

Question 10

Stage 3 Ovarian Cancer

Answer 10

One or both ovaries with peritoneal implants outside of pelvis or + nodes

Question 11

Stage 4 Ovarian Cancer

Answer 11

Distant metastasis

Question 12

What is the treatment of Ovarian Cancer

Answer 12

Surgery

Chemotherapy- platinum and taxane (within 8 weeks of surgery)