Lecture 28 Breast Cancer Flashcards

1
Q

What are the symptomatic presentations of breast cancer

A
Lump
Mastalgia
Nipple discharge (blood stained)
Nipple change (Paget's disease)
Change in size or shape of the breast
Lymphoedema
Dimpling
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2
Q

What tests ca be used to assess the severity of breast cancer

A

FBC, U&Es, LFT, Ca2+/Po2-

CXR

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3
Q

T1 staging

A

Palpable <2cm

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4
Q

T2 staging

A

2-5cm

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5
Q

T3 staging

A

> 5cm

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6
Q

T4a staging

A

Tumour invading skin

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7
Q

T4b staging

A

Tumour invading chest wall

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8
Q

T4c staging

A

Tumour invading skin and chest wall

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9
Q

T4d staging

A

Inflammatory breast cancer

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10
Q

N0 staging

A

No regional lymph nodes palpable

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11
Q

N1 staging

A

Regional lymph node- mobile

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12
Q

N2 staging

A

Regional lymph node palpable- fixed

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13
Q

Mx staging

A

Distant metastasis cannot be assessed

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14
Q

M0 staging

A

No distant metastases

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15
Q

M1 staging

A

Distant metastasis

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16
Q

What is the sentinel lymph node biopsy

A

The first node to receive lymphatic drainage

17
Q

Name factors associated with increased risk of disease recurrence

A
Lymph node involvement 
Tumour grade
Tumour size
Her2 +
Lymphvascular invasion
ER/PR negative
18
Q

Tamoxifen is used in what type of breast cancer

A

ER+

Blocks stimulation of cell growth by oestrogen

19
Q

What drug should only be used in postmenopausal women

A

Aromatase inhibitors
Armidex
Letrozole

20
Q

What is the action of Aromatase inhibitors

A

Inhibiting ER synthesis