Lecture 28 Breast Cancer Flashcards
What are the symptomatic presentations of breast cancer
Lump Mastalgia Nipple discharge (blood stained) Nipple change (Paget's disease) Change in size or shape of the breast Lymphoedema Dimpling
What tests ca be used to assess the severity of breast cancer
FBC, U&Es, LFT, Ca2+/Po2-
CXR
T1 staging
Palpable <2cm
T2 staging
2-5cm
T3 staging
> 5cm
T4a staging
Tumour invading skin
T4b staging
Tumour invading chest wall
T4c staging
Tumour invading skin and chest wall
T4d staging
Inflammatory breast cancer
N0 staging
No regional lymph nodes palpable
N1 staging
Regional lymph node- mobile
N2 staging
Regional lymph node palpable- fixed
Mx staging
Distant metastasis cannot be assessed
M0 staging
No distant metastases
M1 staging
Distant metastasis
What is the sentinel lymph node biopsy
The first node to receive lymphatic drainage
Name factors associated with increased risk of disease recurrence
Lymph node involvement Tumour grade Tumour size Her2 + Lymphvascular invasion ER/PR negative
Tamoxifen is used in what type of breast cancer
ER+
Blocks stimulation of cell growth by oestrogen
What drug should only be used in postmenopausal women
Aromatase inhibitors
Armidex
Letrozole
What is the action of Aromatase inhibitors
Inhibiting ER synthesis
