Lecture 27 Breast Pathology Flashcards
How many lobes does each breast have
8-10
At the end of each lobule there are tiny sacs (bulbs) that can produce____
Milk
What is a fibroadenoma
Proliferation of epithelial and stroll cells of the breast
Benign
Young women
Intraduct papilloma is more common in___
Middle aged women
Name a common symptom of introduction papilloma
Nipple discharge
What benign tumour presents as a fleshy tumour, leaf-like pattern and cysts on cut surface histologically
Phyllodes Tumour
What are the risk factors of Breast carcinoma
Gender Age Menstrual history Age at first pregnancy Radiation FH Personal history Hormonal treatment Genetic factors Lifestyle: obesity, lack of physical activity, alcohol
What are the 4 main genes responsible for hereditary susceptibility to breast cancer
BRCA1
BRCA2
TP53
PTEN
Name 2 types of non-invasive breast cancers
Ductal Carcinoma in Situ (DCIS)
Lobular Carcinoma in Situ (LCIS)
Name 2 types of invasive breast cancers
Invasive Ductal Carcinoma
Invasive Lobular Carcinoma
Are in situ carcinomas detected clinically
No
Detected on Xray or screening
What investigations are carried out to diagnose breast cancer
Mammorgram US, MRI FNA Needle core biopsy WLE
What age group is included in the breast screening programme
50-70 years
Do ER/PR postive breast cancers have good response to hormonal therapies
Yes
What is the treatment for Her2 positive breast cancers
Herceptin
