Lecture 24- respiration Flashcards

1
Q

the upper respiratory tract contains

A

nasal cavity
pharynx
larynx

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2
Q

site of gas exchange

A

alveoli

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3
Q

common passageway shared by respiratory and digestive system

A

pharynx

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4
Q

why is the surface of the lungs moist?

A

thin layer of fluid for oxygen to dissolve into before it can diffuse across the alveolar and capillary endothelium

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5
Q

why does the trachea have rings?

A

to prevent collapse from pressure changes

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6
Q

why does air move into the lungs?

A

the gas pressure in the lungs is less than atmospheric pressure

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7
Q

why does air move out of the lungs?

A

gas pressure in lungs is more than atmospheric pressure
(pressure moves to region of lower pressure)

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8
Q

our respiratory system is optimized to take advantage of

A

bulk flow and diffusion

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9
Q

distance between alveolar airspace and capillary endothelium is —-, allowing gases to diffuse —- between them

A

short, rapidly

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10
Q

how many cell membranes does a molecule of O2 need to cross to get from the inside of an alveolus into blood?

A

4 cell membranes
(2 cells)

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11
Q

lower respiratory system

A

trachea
primary bronchi (R, L)
many smaller bronchi
bronchioles
alveoli

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12
Q

functions of the respiratory system

A
  1. Gas exchange: O2 uptake and CO2 release
  2. Regulating body pH (homeostasis)
  3. Conditioning of inspired air
  4. Protection: filtering and clearing foreign particles
  5. Vocalization
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13
Q

External respiration

A

= movement of gases between internal environment of body and external environment

inspiration and expiration

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14
Q

describe the 3 types of exchange

A

exchange 1: atmosphere to lungs (ventilation)

exchange 2: lungs to blood

exchange 3: blood to cells

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15
Q

muscles used for ventilation

A

external intercostals and diaphragm

for forceful breathing, sternocleidomastoids and scalenes are recruited

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16
Q

pleural membranes

A

= fluid-filled ballon that wraps around lungs

  1. visceral pleural membrane
  2. parietal pleural membrane
17
Q

what is the pleural membrane made of?

A

a thin layer of secretory epithelial cells and a thin layer of connective tissue

18
Q

what does the pleural sac do?

A

protects lungs

pleural fluid lubricates membranes so they can slide against each other during ventilation

“sticks” the lungs tightly to the thoracic wall; to keep lungs inflated!

19
Q

role of the airways

A

filter out foreign substances
- ciliated epithelium
line the trachea and bronchi

warm air to body temp

adds water vapor

20
Q

how does mucus move out of respiratory tract?

A

epithelial cells lining the airways secrete saline and mucus

cilia move the mucus layer towards the pharynx, removing trapped pathogens and particles

21
Q

How is resistance or air flow changed?

A

resistance is changed by radius!!!!
a small change in radius (r^4) created a large change in resistance (R)

22
Q

What is R proportional to?
length or airways
viscosity
resistance

A

R proportional to Ln/r^4

L= length of airways
n= viscosity of air
r= radius

23
Q

How does radius change? (the radius of the trachea and bronchi can’t change)

A

Mucus built up in the trachea and bronchi is a common cause of increased airway resistance!!!

24
Q

Can bronchioles change their radius?

A

YES
they are collapsible
radius can be changed by neural, hormonal and paracrine effects on smooth muscle

25
Q

obstructive lung diseases —– airway resistance

A

increase

26
Q

Resistance depends on total —–

A

cross sectional area

27
Q

where is the most resistance to flow?

A

trachea and bronchi (small TOTAL cross sectional area)

28
Q

where is least resistance to flow?

A

bronchioles; large TOTAL cross sectional area

29
Q

what significantly increases resistance in bronchioles?

A

bronchoconstriction

30
Q

Bronchodilation

A

=decreased resistance to airflow

Paracrine response to:
CO2

SNS response:
norepinephrine/epinephrine bind to beta 2-adrenergic receptors: relaxation of bronchiole smooth muscle

31
Q

Bronchodilation SNS response pathway

A

Gs–> AC –> cAMP –> PKA

32
Q

Bronchoconstriction

A

= increased resistance to airflow

paracrine response to:
-histamine released by local mast cells in an immune response

PNS response:
-ACh binds to muscarinic receptors (M3) –> constriction of smooth muscle

33
Q

Bronchoconstriction PNS response pathway

A

Gq–> PLC–> IP3–> IP3R–> Ca2+

34
Q

how many alveoli do we have?

A

approx 300 million
-600ft^2 surface area

35
Q

each alveolus is made of

A

one layer of epithelial cells

36
Q

type I alveolar cells

A

gas exchange
make up 95% of alveolar surface area

37
Q

type II alveolar cells

A

make and secrete surfactant

38
Q

surfactant

A

a fluid that lines all the alveoli

makes them easier to expand and prevents them from collapsing

39
Q

how are the alveoli optimized for diffusion?

A

v thin
v little interstitial fluid

alveolus and capillary are held close together by fused basement membranes