Lecture 2: Connective tissues, cartilage and bone Flashcards

1
Q

What is connective tissue

A

It is whats left over after everything else is removed (epithelia, muscle and nervous tissue)

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2
Q

T or F: CT has relatively few cells

A

true

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3
Q

Major characteristic of connective tissue

A

abundant matrix

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4
Q

CT is classified based on what

A

type of matrix
fiber density
fiber organization

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5
Q

Functions of CT

A

Physically support other tissues
bind other tissues together
provide structural framework/opposes gravity
create body contours
house specialized tissue (hematopoietic, lymphoid tissue)

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6
Q

Types of CT (3)

A

Embryonic
Adult
Special

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7
Q

Embryonic CT

A

Whartons jelly

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8
Q

Types of adult CT

A

Loose (Areolar)
Dense
Elastic
Reticular

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9
Q

Types of specialized CT

A

Adipose
Hematopoietic
Bone
Cartilage

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10
Q

Components of CT (3)

A

Cells
Fibers
Amorphous, non cellular material

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11
Q

Cells of CT (7)

A

Fibroblast, fibrocyte
chondroblast, chondrocyte
osteoblast, osteocyte, osteoclast

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12
Q

Types of protein fibers (3)

A

Collagen
Elastic
Reticular

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13
Q

Amorphous, non cellular materials

A

GAGs
Glycoproteins
Chondroitin sulfate (in cartilage)
Hydroxyapatite (in bone)

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14
Q

Where is embryonic CT found

A
Umbilical cord (whartons jelly)
pulp of developing teeth
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15
Q

Ratio of fibroblasts:fibrous component in loose (areolar) CT

A

High ratio of fibroblasts to fibrous component

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16
Q

Types of fibers in loose CT

A

Type I collagen and elastic fibers

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17
Q

Where is loose CT found

A

Usually beneath epithelial tissues of most organs, including the tunica adventitia of blood vessels

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18
Q

What does loose CT contain (3 cells, 1 structure)

A

Fibroblasts, mast cells, macrophages, capillaries

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19
Q

Ratio of fibroblasts to fibrous component in dense CT

A

High ratio of fibrous component to fibroblasts

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20
Q

Fibroblast nuclei appearance in dense CT

A

Elongated and thin

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21
Q

Characterized by highly ordered bundles of collagen separated by single rows of fibroblasts

A

Dense CT

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22
Q

Found in tendons and ligaments

A

Dense CT

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23
Q

Compare collagen structure in dense and loose CT

A

Dense CT has thicker bundles of collagen fiber

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24
Q

Types of adipose tissue

A

White fat

brown fat

25
Q

Which type of adipose is unilocular, which type is multilocular

A

white fat is unilocular

brown fat is multilocular

26
Q

Brown fat is used for

A

heat production

27
Q

Most common cells in CT matrix

A

Fibroblasts and Fibrocytes

28
Q

Ground substance of CT matrix

A

Mostly composed of GAGs and glycoproteins

29
Q

Fibers in CT matrix

A

Mostly collagen, also has elastic and reticular

30
Q

What are GAGs

A

Large, negatively charged linear polymers, consisting of repeated disaccharide units

31
Q

T or F: All GAGs are covalently linked to protein to form proteoglycans

A

True, except for Hyaluronic acid

32
Q

Characteristics of Hyaluronic acid

A

Largest GAG
Lacks sulfate group
Present in nearly all CT
Binds to water, serves as lubricant in synovial fluid

33
Q

Four groups of GAGs

A

Heparin and Heparan sulfate
Chondroitin sulfate and dermatan sulfate
Keratan sulfate

34
Q

Types of Glycoproteins (2)

A

Chondronectin

Laminin

35
Q

Cartilage extracellular matrix

A
Collagen fibers (type II).. type I in fibrocartilage
Amorphous ground substance (Hyaluronic acid, chondroitin, keratan and heparin sulfate)
36
Q

Cartilage functions

A
Compressible
Resists distortion
Absorbs shocks in joints
Reduces friction in movable joints
Necessary for endochondral bone growth
Involved in bone fracture repair
37
Q

Cartilage characteristics

A

Perichondrium

Avascular (slow to heal)

38
Q

Perichondrium layers

A

Outer fibrous layer surrounding mass of cartilage, contains fibroblasts
Inner chondrogenic layer- gives rise to chondroblasts

39
Q

Types of cartilage

A

Hyaline
Fibrocartilage
Elastic

40
Q

Hyaline cartilage location

A

Ears, nose, movable joint surfaces

41
Q

Elastic cartilage location

A

Auricle, Epiglottis

42
Q

Fibrocartilage location

A

Less movable joints and intervertebral discs

43
Q

Lacunae

A

Pockets within the matrix where chondroblasts and chondrocytes are found (2-8 in each)

44
Q

Growth pattern of hyaline cartilage

A

Appositional or interstitial

45
Q

Hyaline cartilage characteristics

A
Perichondrium (except at ends of long bones)
Chondrocytes in cell groups
Translucent bluish gray/white
Solid but flexible
Type II collagen
Avascular
46
Q

What is the most common cartilage

A

Hyaline

47
Q

Cartilage develops in regions of ____ oxygen

A

Regions of low oxygen

48
Q

Hyaline cartilage is associated with what types of joints

A

Synovial (diarthroses), highly movable joints

49
Q

Territorial matrix

A

surrounds each chondrocyte

High GAG content, low collagen content

50
Q

Inter-territorial matrix

A

Surrounds territorial matrix

High collagen content, low GAG content

51
Q

Elastic cartilage characteristics

A

Perichondrium
Yellow color due to presence of elastic fibers
More opaque, flexible and elastic than hyaline
Mostly single chondrocytes
Type II collagen + elastic fibers

52
Q

Fibrocartilage characteristics

A
NO perichondrium
Increased collagen
Reduced cellularity compared w/hyaline
Type I collagen
Single sparse chondrocytes
53
Q

T or F: Bone is highly vascular

A

True

54
Q

Matrix of bones consists of

A

Organic component- osteoid

Inorganic component- Hydroxyapatite, makes up 35-65% of the matrix

55
Q

Types of bone tissue

A

Woven
Spongy
Compact

56
Q

Woven bone characteristics (4)

A

Occurs during bone development and repair
Produced rapidly
Haphazard collagen foundation
Less structural integrity

57
Q

Compact (lamellar) bone characteristics

A

Matrix ordered into layers called laminae
Layers may be flattened and parallel
Layers may be concentric and parallel around central canal (Haversian canal)

58
Q

Spongy bone (trabecular or cancellous bone) characteristics

A

3-D lattice of branching, bony spicules intertwined to form trabeculae, surround bone marrow spaces in long and flat bones