Lecture 16: Atherogenesis Flashcards
1
Q
where in the artery do plaques develop
A
tunica intima
2
Q
what are plaques made up of
A
- cells
- matrix components
- lipids
3
Q
how does oxidised LDL direct monocytes to sites of lesions
A
stimulates expression of VCAM-1 and MCP-1
4
Q
what causes proliferation and migration of VSMCs
A
- PDGF
- TGF beta
secreted by endothelial cells and macrophages
5
Q
what are possible reasons for endothelial injury
A
- raised LDL
- haemodynamic stress
- hypertension
- smoking
6
Q
how do statins decrease plasma lipid levels
A
- is HMG CoA reductase competitive inhibitor
- inhibits cholesterol synthesis
- activates SREBP-2
7
Q
effects of SREBP-2
A
- increased LDL receptor expression
- increased PCSK9 expression
