Lecture 10: Drug Treatments for CVD Flashcards
1
Q
at what blood pressure is hypertension treatment required
A
150/95 mmHg
2
Q
how dos the sympathetic system regulate frequency and force of heart contraction
A
- beta 1 receptors
- noradrenaline
- increased cAMP
- increased calcium
3
Q
how does the parasympathetic system decrease frequency of contraction
A
- M2 receptors
- acetylcholine
- decreased cAMP
4
Q
what does angiotensin do
A
- increases sympathetic activity
- increases tubular sodium and chloride reabsorption
- increases sodium and water retention
- stimulates aldosterone secretion
- constricts arterioles
- stimulates ADH secretion
5
Q
what are the steps of the renin-angiotensin-aldosterone system
A
- decrease in renal perfusion detected by juxtaglomerular apparatus
- increased renin which converts angiotensinogen to inactive angiotensin I
- activated to active angiotensin II by ACE
- acts on AT 1 recptors to increase sympathetic activity
6
Q
how is the total peripheral resistance regulated
A
- increase in angiotensin II
- increase in IP3
- increase in intracellular calcium
- constricts arterioles and venules
7
Q
which drugs would you prescribe for an under 55 year old with hypertension
A
- ACE inhibitor
- angiotensin receptor blocker
8
Q
which drugs would you prescribe for an over 55 year old with hypertension
A
calcium channel blocker
9
Q
which drugs would you NOT prescribe to people of african descent
A
- ACE inhibitors
- beta blockers
