Lecture 13: Drug Treatments for Ischaemic Heart Disease Flashcards
what is stable angina
predictable pattern of pain during exercise that is relieved by rest
side effects of nitrates
- postural hypotension
- headache
- dizziness
- reflex tachycardia
what effects do nitrates have
- decrease preload and therefore workload
- decrease peripheral resistance
- cause arterial vasodilation to increase oxygen supply
what can you give to counteract reflex tachycardia caused by nitrates
beta blockers like bisoprolol
example of a nitrate
glycerol trinitrate
side effects of beta blockers
- bronchoconstriction
- fatigue
- contraindicated in patients with peripheral vascular disease
what are the types of calcium channel blockers
- phenylalkylamines
- benzothiazepines
- dihydropyridines
what effect do phenylalkylamines and benzothiazepines have
decrease frequency and force of contraction
what effect do dihydropyridines have
increase dilation of arterioles
what effect does ivabradine have
- targets pacemaker current in nodal tissue
- decreases frequency of contractions but not force
side effects of ivabradine
- luminous phenomena in retina
- blurred vision
- dizziness
example of long acting nitrates
isosorbide mononitrate
effects of nicorandil
- dual action drug so acts as nitrate like drug and potassium channel opener
- dilates peripheral arterioles
- dilates coronary vessels
how does ranolazine work
blocks late sodium current, reducing sodium entry into the cell
