Lecture 13: Osteochondrosis and Subchondral Cystic Lesions Flashcards
what lesions can be considered Developmental Orthopedic Disease (DOD)
OCD, angular limb deformities, SCB cysts, physitis, flexural deformities, cuboidal bone deformity, vertebral malformation
What is Osteochondrosis
Failure of endochondral ossification in articular-epiphyseal complex (growth plate)
What is Osteochondritis dissecans (OCD)
Clinical condition of synovitis due to disrupted joint surface due to DOD
What are Subchondral bone cysts (SCB)
Invaginations into the bone just below the articular cartilage filled with debris and lined with fibrous tissue
What is juvenile osteochodnral conditions
Specific to disturbance of chondral ossification of the AE complex
Describe endochondral ossification
Starts as cartilage and as cartilage expands it ossifies from center to outward
Where are the locations for endochondral ossification
- Epiphysis, joint surface, metaphysical growth plate
- Secondary ossification center s- carpal and tarsal bones, apophyses
Failure of endochondral ossification results in __which in legs causes ___ and in neck causes ___
Osteochondrosis
Leg- lameness
Neck- neurological signs (wobblers)
What is the zone of hypertrophy
Chondrocytes are fatter and expanding as cartilage and then ossify behind
What is the blue arrow pointing at
zone of hypertrophy
Lesions of Osteochondrosis are a result of persisting ___
Chondrocytes in the zone of hypertrophy— cartilage becomes thicker but doesn’t ossify
What can cause chondrocytes to persist in zone of hypertrophy
- Failure of vascular invasion
- Failure of ossification
what does this show
Failure of Osteochondrosis, cartilage becomes thicker, not strong
What does this show
left: Osteochondrosis (not dissecans because hasn’t broken off yet)
Right: healing but still cartilage, bone has just formed around
What does this show
OCD on trochlear ridge
What does this show
Subchondral bone cyst
What happens in the formation of Subchondral bone cyst
Articular defect allows synovial fluid pressure into Subchondral bone causing bone resorption
Enlarges until pressure equilibrates
OCD vs SBC, which forms from weight bearing
SBC
OCD vs SBC: which occurs from shear forces on gliding surfaces
OCD
OCD vs SCB: which forms from compressive forces on loaded areas
SCB
What is wrong here
Subchondral post cyst
What are some possible factors of OC
- Growth rate
- Diet
- Heritability
- Trauma (normal trauma on defective cartilage and excessive trauma on healthy cartilage)
- Exercise
Excess ___in diet is strongly implicated in OC
Energy- excess phosphorous and calcium
Deficiency in what trace mineral is linked to OC
Copper
Excess of what mineral leads to OC
Zinc
What does a deficiency in cooper cause to result in OC
Failure of hydroxylysine cross link in collagen (loss -of “grass in adobe”)
Lysyl oxidase requires Copper
What is the heritable cause for OC
Propensity for rapid growth (not a particular gene)
What are some clinical signs of OC
- Joint effusion
- Lameness
- DJD
OC can be asymptomatic if fragment is stable, you may need to ___if for sale
Treat the radiographs
What is the synovial fluid analysis like for OC
Normal