Lecture 10.24.14 (Exam #3)

Question 1

TIM

Answer 1

converts DHAP to GAP although the cell prefers to have a high {DHAP}

Question 2

GAPDH

Answer 2

converts GAP to 1,3 BPG

Question 3

What is the mechanism of GAPDH?

Answer 3

destabilize the transition state (high energy)
make thioester
lowers activation energy

Question 4

NAD+ acts as a _____ in GAPDH

Answer 4

coenzyme

Question 5

What is used in GAPDH to make the phosphate bond?

Answer 5

inorganic phosphate

Question 6

T/F PGK is a substrate level phosphorylation.

Answer 6

TRUE

Question 7

Mutase

Answer 7

a type of isomerase (Pi before and after catalysis)

Question 8

How is PK regulated?

Answer 8

ATP & alanine inhibit

F26BP

Question 9

F26BP participates in the ______ of PK.

Answer 9

feed forward activation

Question 10

The big three enzymes that are metabolically irreversible?

Answer 10

hexokinase, PFK, PK

Question 11

If there are high concentrations of glucose in the liver….

Answer 11

insulin in the pancreas tells glycolysis CAN happen

Question 12

When there are high concentrations of glucose in the liver there is more (3)

Answer 12

copies of glucokinase
more F26BP
more copies of PK (PK w/o phosphate)

Question 13

If there are low concentrations of glucose in the liver…..

Answer 13

glucagon in the pancreas tells glycolysis CAN NOT happen

Question 14

When there are low concentrations of glucose in the liver there is less (3)

Answer 14

copies of glucokinase
less F26BP
less copies of PK (PK with phosphate)

Question 15

What is the purpose of fermenation (2)

Answer 15

to keep glycolsis going without the presence of oxygen

to supply GAPDH with NAD+

Question 16

What enzyme drives pyruvic acid to lactic acid

Answer 16

lactate dehydrogenase

Question 17

in the heart;_____-> ______

in the muscle;_____ -> _____

Answer 17

LA to PA

PA to LA

Question 18

Lactic Acid is made up of ____ monomers

Answer 18

4 tetramers of H&M

Question 19

Where does the Cori Cycle begin?

Answer 19

in the muscle

Question 20

(Cori Cycle) In the muscle; glucose is converted to ___ then ___

Answer 20

PA to LA

Question 21

(Cori Cycle) After LA is produced in the muscle what happens

Answer 21

LA is sent to the liver via the bloodstream

Question 22

(Cori Cycle) LA is converted to pyruvic acid and then back to glucose via

Answer 22

glucogenesis