Lecture 10.17.14 (Exam #3) Flashcards
Stage 1 of catabolism
polymers to monomers: no ATP is made
Stage 2 of catabolism
monomers to intermediates (metabolites): little ATP made
Stage 3 of catabolism
intermediates to rawest form (CO2): lots of ATP
Where is glucose for glycolysis found?
Liver & Muscles
Polymer of Glucose
Glycogen
If glucose is needed the _____ will release it in the ____?
Liver;blood
2 hormones that affect concentration of glucose in bloodstream
glucagon (pancreas)
adrenaline (brain)
Glucagon
hormone produced by the pancreas to raise the concentration of glucose in the bloodstream
(LIVER)G.phosphorylase converts glycogen to _______
Glucose 1 phosphate (G1P)
(LIVER)Which enzyme converts glycogen to G1P?
G.phosphorylase
(LIVER)Mutase converts glucose 1 phosphate to _______
Glucose 6 phosphate (G6P)
(LIVER)Which enzyme converts G1P to G6P?
Mutase
G6P gets split into _____ & _____
glucose & 5 carbon sugar
What are transporters used for?
to let glucose out of liver and into the muscle
What are transporters?
membrane bound proteins that allow specific molecules to pass
GLUT
transporters of glucose
Where is GLUT 1 & 3 found?
every cell has these receptors
Where is GLUT 2 found?
liver & pancreas
Where is GLUT 4 found?
muscles & fat cells (adipose tissue)
Where is GLUT 5 found?
small intestine
(MUSCLE) ______ along with ATP is used to convert glucose to G6P
hexokinase
T/F G6P can pass through GLUT
FALSE
Hexokinase undergoes a _____ _____ _____and ____ is coupled with ATP?
dramatic conformational change; Mg+2
Why is Mg+2 attached to ATP?
to stabilize negative charges
What would happen if H2O entered the active site of hexokinase?
glucose would not pick up phosphate, but water instead
What is a tactic used by an enzyme that does not want water in their active site?
they undergo a dramatic conformational change
What is a competitive inhibitor of hexokinase
G6P
product inhibition
when a product of a reaction catalyzed acts as a competitive inhibitor for an enzyme
ex. hexokinase (G6P)
hexokinase vs. glucokinase
glucokinase is found in the liver and has a lower affinity than hexokinase
