lecture 1 Flashcards

1
Q

The cell membrane is a highly selective filter that:
ØActively maintains unequal concentrations of ions across it
ØServes as a filter that allows nutrients to enter and waste to leave the cell

A

ØActively maintains unequal concentrations of ions across it

ØServes as a filter that allows nutrients to enter and waste to leave the cell

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2
Q

the cell membrane has two main components

A
  • phospholipid billyer

- proteins

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3
Q

______________ most abundant; have glycerine backbone;
amphipathic molecules -have a polar, hydrophilic head; and two
non-polar, hydrophobic tails, e.g. phosphatidyl choline

A

a. Phosphoglycerides:

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4
Q

what lipids make up the membrane

A

a. Phosphoglycerides:
b) Sphingolipids
c) Sterols

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5
Q

__________–have a sphingosine backbone; amphipathic molecule,
e.g. sphingomyelin

A

b) Sphingolipids

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6
Q

_______________–non-polar, e.g. cholesterol

A

c) Sterols

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7
Q

The membrane is impermeable to ions. ____________ allow the passage of
ions through the membrane.

A

Proteins

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8
Q

____________– catalyze reactions

A

a) enzymes

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9
Q

_______________________ - for hormones, etc.

A

b) receptor molecules

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10
Q

________________s – allow entry/exit of substances through

the membrane

A

c) passive channels/pores

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11
Q

____________________ – active transport across the membrane

A

d) pumps

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12
Q

_______________– passive transport: the protein binds the ion and
transports it by diffusion or rotates to flip the ion to the other side of
the membrane

A

e) carriers

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13
Q

Membranes divide cells into physically separate compartments,
which allows:

A

1) Control of solute concentrations
2) Storage of energy to do work
1) chemical energy – by establishing concentration or
electrochemical gradients
2) electrical energy – by establishing charge separatio

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14
Q

_______________ – by establishing concentration or

electrochemical gradients

A

1) chemical energy

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15
Q

________________– by establishing charge separatio

A

2) electrical energy

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16
Q

-permeation of solutes across a barrier

A

Passive Diffusion

Fick’s Law of Diffusion: dS/dt = Px(C1-C2)

17
Q

depends on how soluble a solute is in the membrane – non-polar
substances have a greater Px than polar substances, thus they are MORE
permeable

A

Permeability Constant

Px

18
Q
- the Neuron Doctrine: the nervous system is made up of discreet
signaling elements (neurons)
A

1) Santiago Ramón y Cajal (Spain)

19
Q

-discovered and developed histological staining techniques –cells are
impregnated with silver grains (Golgi stain)

A

2) Camillo Golgi (Italy)

20
Q

The brain exhibits three principle types of behavior:

A

1) Sensory
2) Movement
3) Cognitive
- All are based on electrical processes

21
Q

The membrane itself has a very high ______________ – channels may be considered
as variable resistors61 in the membrane

A

resistance

22
Q

Channel types:

A

1) Open Channels (or Leakage Channels)

2) Gated Channels

23
Q

types of Gated Channels

A

1) Voltage-gated
2) Ligand-gated
3) Stretch-activated or mechanosensory (MS)

24
Q

Active transport

Ø Requires ATP for energy
Ø Active in absorption/secretion and maintaining
Vm
Ø Pumps 3Na+ (out):2K+ (in)

A

Performed by “pumps” which require energy e.g.

Na+K+-ATPase (Na+-K+ Pump)

25
Q

_______________

Ø Requires ATP for energy
Ø Active in absorption/secretion and maintaining
Vm
Ø Pumps 3Na+ (out):2K+ (in)

A

Active transport

26
Q

Blocked by cardiac glycosides:

A

1) From dried leaves of foxglove plant-digitalis
2) From Strophanthus plant-ouabain
3) CGs found in venom of certain toads

27
Q

Cell membrane is_____________e (this means at rest, it is mostly
permeable ______________

A

selectively-permeable

to potassium)

28
Q

Remember, membrane potential is measured as the difference in voltage across the
membrane - that is, it is ____________where the outside is conventionally taken to be at __________________

A

the potential of the inside of the cell relative to the outside (typically
Vm= -70 mV)

(0 V)

29
Q

Ionic concentrations in ______________ for a typical mammalian muscle cell:

A

(mM)

30
Q

______________ takes into account the permeability of the membrane to. more than one moncovalent ion. For only one permeable ion, it reduces to the Nernst equation

A

Goldman equation

31
Q

_____________ is when KCL is equal on either side of the SPM, the net ionic flow=0

A

Donnan equalibrium