Lecture 1-3 Flashcards
What is the prominent feature in Megakaryocyte Stage III
Multilobulated nuclei
what stage where alpha and dense granules have fully developed and demarcation membrane system is also fully developed?
What is the color of the granules seen in this stage
Megarkaryocyte Stage III/Megakaryocyte
reddish-blue granules
process where a single megakaryocyte shed platelets
how many platelets where shed by a single megakaryocyte
thrombopoiesis
2000-4000
Where does the platelet released before it reaches circulation?
Describe the cell stated above.
via sinuses
Megakaryocyte with platelet budding
prominent feature for megakaryoblast
plasma membrane bleb
What stage where in it reaches its full ploidy level
End of Promegakaryocyte or MK-II stage
T OR F. Megakaryocyte is adjacent to the membrane of the sinusoid lining endothelial cell
True
TPO receptor site present st all maturation stages
MPL
seen in early stages, a stem cell and common myeloid progenitor marker which disappears as differentiation proceeds
CD34
What techniques that can detect cytoplasmic coagulstion factors and uses tossue samples
Immunostaining
Techniques that uses antibodies that are directed against particulsr markers such as CD61
immunohistochemistry
naked megakaryocyte nuclei are left behind and consumed by?
marrow macrophage
primsry source of the impt. hormone in megakaryocytopoiesis
Liver
acts in synergy in TPO to induce the early differentiation of stem cells
IL-3
help enhance endomitosis, megakaryocyte maturation and thrombocytopoiesis
IL-11
What are the substance that keeps things in check so that there arent too many megakaryovytes produce
platelet factor ,r
Beta-thromboglobulin
neutrophil-activsting peptide 2
interleukin 8
Where does the platelet originate
megakaryocyte cytoplasm from bone marrow
unique form of mitosis that occurs in megakaryocytic cells resukting in continues DNA reduplication without telophase and cytokines
Endomitosis
Life span of platelets
9.5 days
T or F. MPV as a predictor of mortality and cardiovascular risk
What is the MPV range for platelet
TRUE
8-10 femtoliter
Markedly larger than ordinary platelets
What does it carry?
Reticulsted platelets or Stress platelets
free ribosimes and fragments of rough endoplasmic reticulum
Reticulated platelets is associated with what risk?
increased risk of cardiovascular disease
A platelet cytoskeleton that mainstains the platelet’s discoid shape
Microtubules
A platelet activstion pathway that ends with the production of prostacyclin
Elcosanoid Pathway
