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Hematology > Hema Lec #6: Fibrinolytic Series > Flashcards

Hema Lec #6: Fibrinolytic Series Flashcards

1
Q

What is the main stimulus of contact group?

A

negatively-charged substance

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2
Q

All but one is true about D-Domains.
A. it is known as N-DSK where the 3 pairs of fibrinopeptide chains linked together by disulfide bonds
B. Alpha and beta fibrinopeptide chains
C. still connected with disulfide bonds, short polar appendage of the carboxy-terminal ends of the alpha chain
D. no longer connected with disulfide bonds, long polar appendage of the carboxy-terminal ends of the alpha chain

A

D. no longer connected with disulfide bonds, long polar appendage of the carboxy-terminal ends of the alpha chain

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3
Q

What Steps in conversion to fibrin where thrombin cleaves the alpha and beta fibrinopeptide chains of the fibrinogen in the E-domain.

A

Enzymatic

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4
Q

What mechanism is used during formation of fibrin polymer of polymerization

A

D-E contact

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5
Q

Substances that can dissolve the fibrin polymer

A

5M urea

1% Monochloroacetic acid

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6
Q

What fragment is produced during the first attack of plasmin

A

Fragment X

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7
Q

Inhibits factor Xa and TF:VIIa

A

TFPI(Tissue Factor Pathway Inhibitor)

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8
Q

effective cofactor to protein C

A

Free Protein S

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9
Q

Come from outside the body that is Usually commercially prepared thrombolytic agents

A

Exogenous Plasminogen Activators

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10
Q

Primary inhibitor of thrombin

A

Heparin Cofactor II

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11
Q

The Routinely used thrombolytic agent in the market is derived from what specific beta-hemolytic streptococci

A

Streptococcus equisimilis

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12
Q

Inhibits activated forms of Factors XII, XI, X, IX and

prothrombin, Also inhibit plasmin and kallikrein

A

Antithrombin III OR Heparin Cofactor I

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13
Q

What happens during the third attack or action of plasmin.

A. cleave/destroy carboxy-terminal ends of the
alpha chains in the D-domain
B. destroy the attachment of the D-domain to
the E domain of fragment Y
C. One of the D domains from fragment X is
cleaved

A

B. destroy the attachment of the D-domain to

the E domain of fragment Y

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14
Q

2 forms of Protein S in the circulation

A

Free Protein S
Protein S Bound to complement C4 Binding
Protein

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15
Q

Test for FDP’s

A

Thrombo-Wellcotest

D-Dimer test

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16
Q

The degradation of the stable clot by plasmin is done in what specific process?

A

Proteolysis

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17
Q

What cell is associated with storage and trasportation of the zymogen in the plasma that will give rise to the active enzyme responsible for the events in the fibrinolytic system

A

eosinophil

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18
Q

Principle used in test for FDP’S Thrombo-Wellcotest and D-Dimer test

A

Direct latex agglutination slide test

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19
Q

Specific fragments produced by the degradation of

fibrinogen or fibrin

A
  • Fibrinogen/Fibrin Degradation Products OR

- Fibrinogen/Fibrin Split Products)

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20
Q

principle for D-Dimer (D-DI test)

A

Direct latex agglutination slide test

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21
Q

True or False. Reagent in D-Dimer is sensitized with anti-fibrinogen antibodies

A

False.

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22
Q

Staphylokinase is derived from?

A
  • Staphylococcus aureus

- Yersinia pestis

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23
Q

What term is used to call the fibrin polymer product with cleaved carboxy-terminal ends of alpha chain?

A

Fragment X

24
Q

What inhibitor of fibrinolysis removes the lysine binding sites in the fibrin surface?

A

Thrombin Activatable Fibrinolysis Inhibitor

25
Q

Enzyme that is Capable of attacking the protein molecules in

the body and cause massive destruction

A

Serine protease enzyme

26
Q

What molecule is responsible for the indirect liberation of tPA from the endothelial cells?

A

Activated protein C

27
Q

What are the two degradation products of fibrin?

A
  • Fragment E

- D-dimer

28
Q

Degrades both fibrin in clots and fibrinogen in the

circulation

A

Plasmin

29
Q

Measures plasminogen activator concentration

A

Euglobulin Lysis Time

30
Q

True or False. Reagents is coated with monoclonal antibodies in Test for FDP’s

A

False.

31
Q

What test that forms a forms a visible gel in the reaction.

A

Ethanol Gelation Test

32
Q

State the two plasmin inhibitors before it causes massive destruction in circlation.

A
  • Alpha2-antiplasmin

- Alpha2-macroglobulin

33
Q

What is the direct stimulus for the liberation of tPA from the sub-endothelium?

A

Bradykinin

34
Q

Blank 1: what are the 2 types of Plasminogen

Blank 2: They are differentiated according to what component

A

Blank 1: Glu-plasminogen AND lys-plasminogen

Blank 2: amino acid terminal end
component

35
Q

A kininogen activator successor of HMWK and only produced when HMWK is activated/ stimulated by kallikrein

A

bradykinin

36
Q

Blank 1: Is a molecule seen in the Protein C
Pathway

Blank 2: What is found in this path that is Vitamin K dependent regulatory proteins

A

Blank 1: Activated Protein C

Blank 2: Protein C and Protein S

37
Q

Blank 1: Primarily a procoagulant enzyme that takes part in
fibrinolysis

Blank 2: Name of the receptor site.

Blank 3: Name the complex when they are bound from each other.

A

Blank 1: Thrombin

Blank 2: Thrombomodulin

Blank 3: Thrombomodulin-bound thrombin OR
thrombin:thrombomodulin complex

38
Q

The Only plasminogen molecule that can attach

to the surface of the stable clot

A

Lys-plasminogen

39
Q

An inactive enzyme which is also known for its first and most important in the fibrinolytic system. Secreted in the liver and normaly seen in plasma

A

plasminogen

40
Q

Plasminogen Activation Inhibitors that is produced by endothelial cells, from bradykinin stimulation and primary inhibitor of t-PA

A

Plasminogen Activator Inhibitor 1

41
Q

True or False. Extrinsic endogenous plasminogen activators are Substances coming from the tissues and it is associated with tissue factor

A

False.

42
Q

Plasminogen Activation Inhibitors that Removes the lysine binding sites at the surface of
stable clot and Removes the lysine carboxy-terminal ends from
fibrin

A

Thrombin-Activatable Fibrinolysis Inhibitor OR Plasma

Carboxypeptidase B2

43
Q

Plasminogen Activation Inhibitors that is Found in placenta and macrophages, Primary inhibitor of u-PA

A

PAI-2

44
Q

An active form of plasminogen that destroys clot through what action or mechanism?

A

proteolysis

45
Q

Plasminogen Activation Inhibitors that is Primary inhibitor of Activated Protein C

A

Plasminogen Activator Inhibitor III

46
Q

Mechanism in the Change of Behavior of Thrombin Includes:

A. Less ability to clot fibrinogen
B. When attached to receptor site, it can further activate the platelet
C. ability to acivate Factor V and Factor VIII
D. No production of activated Factor Va and Factor VIIIa
E. less ability to become platelet agonist

A

A,D,E

47
Q

True or False. Plasmin is normally seen in plasma once plasminogen gets activated

A

False

48
Q

Blank 1: An extrinsic endogenous plasminogen activator that is Found in both plasma and urine

Blank 2: What is its inactive form and active form.

A

blank 1: urokinase plasminogen activator

Blank 2: single-chain urokinase plasminogen activator or scu-PA (inactive form)

two-chain urokinase plasminogen
activator or tcu-PA (active form)

49
Q

where does this substances secreted as inactive enzyme where it is normally found in the plasma and it is the most important in the fibrinolytic system

A

liver

50
Q

what is the normal plasma content of this enzyme where when active, destroys the stabled clot of platelet

A

20 mg/dL

51
Q

what is the shelf life of this enzyme when in active state is not normally seen in the plasma, and when escape to circulation, it needs to immediately destroy by a inhibitor

A

2 days

52
Q

how will the protein C get activated?

A

thru formation of thrombin:thromboglobulin complex

53
Q

T/F. Activated Protein C cannot inactive Factors Va and VIIIa and synthesize t-PA without the help from the cofactor Protein S

A

true

54
Q

it is an effective cofactor for protein C

A

free protein S

55
Q

A protein that neutralizes the PAI-1 so that t-PA can successfully activate enzyme

A

Activated Protein C

56
Q

Primary inhibitor of plasmin

A

A2-antiplasmin

57
Q

secondary inhibitor of plasmin; inhibit the remaining plasmin that is not inhibit by the first inhibitor of plasmin

A

A2-macroglobulin

Hematology (18 decks)

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