Hema Lec #10: Iron Deficiency Anemia

Question 1

T/F. each mL of rbcs contains about 1 mg of iron

Answer 1

true

Question 2

Storage ion is present in the macrophage of reticuloendothelial system in what forms:

Answer 2

Ferritin and hemosiderin

Question 3

A water-soluble storage ion that is present in the macrophage

Answer 3

ferritin

Question 4

T/F. ferritin is a water-insoluble complex of ferric salt and its protein, apoferritin.

Answer 4

False. water-soluble

Question 5

A water-insoluble storage ion that is found in macrophage of reticuloendothelial system.

Answer 5

hemosiderin

Question 6

What receptor that a transport ion binds to when found in erythroid precursor, reticulocyte and most body cells

Answer 6

Transferrin Receptor-1

Question 7

What receptor that a transport ion binds to when found in heptocytes and erythroid precursor?

Answer 7

Transferrin Receptor-2

Question 8

What type of transferrin receptor tat found in erythroid precursor?

Answer 8

tranferrin receptor-1 and transferrin receptor-2

Question 9

Absorption of iron takes place in what specific part of the organ

Answer 9

duodenum and upper jejunum

Question 10

T/F. non-heme iron absorbed more efficiently than heme iron

Answer 10

false

Question 11

Absorption of iron is facilitated by:

Answer 11

ascorbate and citrate

Question 12

Absorption of iron is inhibited by:

Answer 12

phytates and tannins

Question 13

Where does loss/excretion of iron mainly occurs?

Answer 13

Gastrointestinal cells

Question 14

Which of the following does not refer to loss of iron?

a. it occurs in stomach and through the urine. loss in women averages more than in men
b. it occurs in kidney and through the urine. loss in women averages more than in men
c. it occurs in skin and through the urine. loss in women averages more than in men
d. it occurs in kidney and through the urine. loss in men averages more than in women

Answer 14

c. it occurs in skin and through the urine. loss of women averages more than in men due to menstrual cycle

Question 15

which of the following does not refer to non heme iron?

a. mostly in the ferric state
b. needs to be reduced to ferrous by duodenal cytrochrome B
c. moved across the apical membrane into the cytoplasm through transporters that are incomplete characterized
d. none of the above

Answer 15

c. moved across the apical membrane into the cytoplasm through transporters that are incomplete characterized

Question 16

Ferrous iron is transported across the apical membrane by what enzyme?

Answer 16

divalent metal transporter 1

Question 17

before going tp the blood, the ferrous iron needs to cross the basolateral membrane by what enzyme?

Answer 17

ferroportin 1

Question 18

what protein or ambot say tawaf ani that oxidized ferrous to ferric form of iron before entering the blood?

Answer 18

hephaestin and ceruloplasmin

Question 19

What transport ion that binds to newly absorbed iron and delivers to the bone marrow?

Answer 19

plasma transferrin

Question 20

an iron-regulaitng peptide hormone made in liver

Answer 20

hepcidin

Question 21

A membrane protein that endocytosed and degraded the iron when it is inhibited by a iron-regulating peptidee hormone

Answer 21

ferroportin 1

Question 22

What pH when iron-transferrin complex circluates in plasma until it interacts with specific transferrin receptors found on the surface of marrow erythroid cells

Answer 22

pH 7.2

Question 23

Once iron-bearing transferrin binds to receptor, it is internalized via:

Answer 23

clathrin-coated pits

Question 24

after internalizing the iron-bearing transferrin binds to receptor, it is transported to acidic endosome and release at what specific pH

Answer 24

pH 5.5/ low pH

Question 25

it is a state in which the iron content of the body is less than normal. it is also the most common cause of anemia

Answer 25

Iron deficiency anemia

Question 26

What are the causes for increased demand for iron

Answer 26

rapid growth in infancy/ adolescence pregnancy erythropoietin therapy

Question 27

What are the causes for increased loss of iron?

Answer 27

``` chronic blood loss acute blood loss menses phlebotomy in treartment for polycythemia vera blood donation ```

Question 28

What are the causes for decrease iron intake or absorption

Answer 28

Acute or chronic inflammation malabsorption from surgery inadequate diet

Question 29

stain used for iron storage

Answer 29

Prussian blue staining

Question 30

What stage of IDA when demand for iron or blood loss is greater than the absorption for iron

Answer 30

Iron depletion

Question 31

A laboratory test for IDA that indeirectly measures the amount of transferrin in circulating blood

Answer 31

serum total iron binding capacity

Question 32

A lab test for IDA that tells how much of the available ironn binding sites are actually occupied with iron

Answer 32

percent saturation of tibc

Question 33

a good reflection of storage iron

Answer 33

serum ferritin

Question 34

one of the earliest indicators of iron deficiency

Answer 34

erythrocyte porphyrins

Question 35

a lab test for IDA that produced by shedding of membrane transferrin receptors duirng erythrocyte maturation

Answer 35

serum transferrin receptors

Question 36

identify if increased or decreased during IDA a. erythroid porphyrins b. serum ferritin c. percent saturation of TIBC d. serum total iron-binding capacity e. serum transferrin receptors

Answer 36

a. increased b. decreased c. decreased d. increased e. increased