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Hematology > Hema Lec #5: Lab Evaluation of Coag > Flashcards

Hema Lec #5: Lab Evaluation of Coag Flashcards

1
Q

Principle of most hemostasis/Coagulstion test

A

Clot-based testing procedure

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2
Q

All laboratory test in coagulation must incubate in what degree

A

37 degree Celsius waterbath

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3
Q

What will happen if blood is collected in a plastic tube but left standing at room temperature for a long period of time

A

destroyed thermal labile coagulation factors especially Factor VIII:C/destruction of Factor VIII:C

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4
Q

Bpank 1:What factor can be released if there is excessive probing during venipuncture?

Blank 2: The factor released will lead to the activation of what Specific coag system?

A

Blank 1: Tissue factor

B2: Activation of Extrinsic Pathway

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5
Q

Why do we need to collect the secone or third evacuated tube after a non additive in bet wen them

A

To avoid potential carry over contamination of previous anticoagulants

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6
Q

Anticoagulant of choice for most hemostasis testing

A

3.2% sodium citrate

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7
Q

What is the action of the anticoagulsnt of choice for most hemostasis testing

A

chelates the calcium to prevent coagulation

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8
Q

Prolonged tourniquet application could cause:

A

Hemoconcentration

Increased fibrinolytic activity

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9
Q

Sodium Citrate preserves labile coagulation factors IV and VIII

A

False

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10
Q

What specimen is obtained after centrifuged and is the spx of choice for clot-based testing procedure

for how many minutes of spinning and specific gravity for this specimen to obtain

A

Citrated Platelet-Poor Plasma

15-20 minutes at 2500 gravity

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11
Q

What studies used in Citrated Platelet-Rich Plasma

How many minutes required for the centrifugae and gravity to obtain such specimen

A

Platelet Aggregation Studies OR Platelet Aggregometry

10 minutes; 200 gravity

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12
Q

For how many hours does the Citrated platelet-rich plasma needed to store?

A

Room temperature for 3 hrs.

if prolonged, discard and another sample is collected 🤪🤪

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13
Q

Principles of Clotting Time: Time required for the blood to clot. What are the sub-principles that supports the principle of clotting tome

A

After the blood was taken out from the vessels

Upon or after the activation of coagulstion factors

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14
Q

Usefullness of Clotting Time

A

It measures the intrinsic and common pathways of coagulstion

It monitors the effectiveness of heparin anticoagulant therapy

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15
Q

Primary usefulness of clotting time

A

It measures the intrinsic and common pathways of coagulation

Monitors the effectiveness of the heparin anticoagulant therapy

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16
Q

routine used method in clotting time procedure

A

Lee and White Method

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17
Q

Substance used to moiten the integral part of the glass tt

Purpose:

A

Normal Saline Solution

to increase negativity of glass tt

18
Q

What composition of NSS that will help the glass tt increase its negativity

A

Chloride

19
Q

Specimen used for lee and white method

A

Whole blood

20
Q

The main laboratory tests that measures coagulation and hemostasis

A

Activated Partial Thromboplastin Time AND

Prothrombin Time

21
Q

Laboratory test that measures the effect of heparin therapy and to detect circulating anticoagulant

A

Activated Partial Thromboplastin Time

22
Q

What is the principle for APTT

What is its normal value

A

Clot-based testing procedure/ Clot-based test

25-35 seconds

23
Q

Usefulness of APTT

A

It measures the inherited AND acquired deficiency in the intrinsic and common pathway

It monitors the effectiveness of heparin anticoagulant therapy

It detects the presence of circulating anticoagulant

24
Q

2 reagents in APTTA

A

Reagent 1: Partial Thromboplastin Reagent

Reagent 2: Calcium chloride Reagent

25
Q

Reagent 1 is consist of …

A

Phospholipids and Negatively charged substance where phospholipids supplies the citrated platelet-poor plasma

26
Q

Substance that can activate the contact group factor

A

Negatively charged substance

27
Q

What are the negatively charged substance in the APTT

A

silica, kaolin, celite, elagic acid

28
Q

Spx of choice for APTT

A

Citrated Platelet-Poor plasma

29
Q

APTT can measure all the coagulstion factors except…

A

Factor VII and Factor XIII

Factors 7 and Factors 13

30
Q

Complete the senctence.

  1. PT is most sensitive to _____
  2. moderate sensitive to _____
  3. sensitive to _____ and ______
A
  1. Factor VII deficiency
  2. Factor X and V deficiency
  3. Severe fibrinogen deficiency and Prothrombin Fsctor II deficiency
31
Q

Severe deficiency that has a low levels of fibrinogen

A

Hypofibrinogenemia

32
Q

Defeciency that has no fibrinogen st all

A

Afibrinogenemia

33
Q

What substance that is added which react to factor VIIa that will trigger to convert Factor ___ to ____

A

Thromboplastin with calcium

Factor X to Factor Xa

34
Q

Normal values for PT

A

10-13 seconds

35
Q

Usefulness for PT

A

It measures the inherited or acquired deficiencies of the extrinsic and common pathway

It monitors the effectiveness of oral anticoagulant therapy

36
Q

Reagent used for PT

A

Thromboplastin-Calcium Chloride Reagent

37
Q

Commercial name for Thromboplastin-Calcium Chloride

A

Permatime/Simplastin/Thrombotime/Chromoplastin

38
Q

Spx of choice for PT

A

Citrated platelet-poor plasma

39
Q

Least used in reporting PT

A

Percent Activity

40
Q

Recommended and standard metohd in reporting PT especislly for px receiving oral anticoagulant therapy

A

International Normalized Ratio

41
Q

The effectivity of oral anticoagulant therapy is directly proportional to the prolongation of PT

A

True

42
Q

What anticoagulant is used in preservation of labile coagulation factors

what are those labile coag factors

A

sodium citrate

Factor V and Factor VIII

Hematology (18 decks)

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