Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Hematology > Hema lec #7: Lab Evaluation of the fibrinolytic System > Flashcards

Hema lec #7: Lab Evaluation of the fibrinolytic System Flashcards

1
Q

Naturally occuring inhibitor that inhibits thrombon

A

Antithrombin III OR Heparin Cofactor I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

It inhibits activated forms of IX, X XI XII, kallikrein, and plasmim

A

Antirhrombin III OR Heparin Cofactor I

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Antithrombin III or Heparin Cofactor I supresses what system?

A

Coagulation and Fibrinolytic System

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Heparin Cofactor III supresses what specific system?

A

Only supresses the coagulstion system

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Protein C and Proten S regulstes coagulation system by inactivating …

A

Factor Va and Factor VIIIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Onsay naka unique sa Tissue Factor Pathway Inhibitor

A

Bivalent Inhibitor — 1 molecules, inhibits 2 sites

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What coagulstion factor that is being inhibited by TFPI

A

Factor Xa AND TF:VIIa

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

A quaternary complex that is calcium dependent due to vitamin K dependent

A

Xa:TF/VIIa:TF complex

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q 
Aka Heparin Cofactor I
- Naturally-occurring inhibitor
- Inhibits activated forms of Factors XII, XI, X, IX, and
prothrombin
- Also inhibit plasmin and kallikrein
A

Antithrombin III

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

naturally occurring anticoagulant

A

Heparan sulfate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

suppresses the Fibrinolytic System

A

Antithrombin III

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

T/F. Antithrombin III suppresses both coagulation and fibrinolytic
system

A

Truest

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Only suppresses the coagulation system

A

Heparin Cofactor II

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q
  • Vit. K dependent regulatory proteins
  • Regulates coagulation system by inactivating Factors Va
    and VIIIa
A

Protein C & S

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q
  • Primary inhibitor of tPA
  • Inhibits u-PA
  • Produced by endothelial cells upon activation of
    bradykinin
  • Inactivated by APC, thrombin, and plasmin
A

PAI-1

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q
  • Primary inhibitor of u-PA

- Found in placenta and macrophages

A

PAI-2

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

Primary inhibitor of Protein C

A

PAI-3

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Removes lysine-binding sites from stable fibrin so

lys-plasminogen cannot bind to it

A

TAFI (Thrombin Activatable Fibrinolysis Inhibitor)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

Inhibits free plasmin and plasmin liberated from the clot
- Primary inhibitor of plasmin once it has effectively
degraded clot

A

Alpha2-antiplasmin

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

Formation of fibrin monomer

21
Q

Second line of defense in plasmin inhibition in

cases of pronounced fibrinolysis

A

Alpha2-macroglobulin

22
Q

Formation of insoluble fibrin

A

Stabilization

23
Q

Principle: Direct latex agglutination slide test
- Immunologic
- Involves antigen-antibody reaction
- Reagent is sensitized with anti-fibrinogen antibodies
(fragments D & E)
- antisera containing anti-fibrinogen antibodies directed
to Fragment D and E

A

Thrombo-Wellcotest

24
Q
  • Principle: Direct latex agglutination slide test
  • Reagents : antisera coated with monoclonal antibodies to the
    D-dimer
A

D-Dimer (D-DI Test)

25
causes vasodilation to expose collagen
Prostacyclin
26
- Screening procedure for the measurement of fibrinolytic activity of the patient plasma - Measures plasminogen activator concentration in the patient’s plasma
Euglobulin Lysis Time
27
Specimen of choice for ethanol gelation test
citrated platelet-poor | plasma
28
Most common paracoagulation test for screening | disseminated intravascular coagulation
Ethanol Gelation Test
29
``` - Increased activity of the coagulation system, slower fibrinolytic system - Imbalance of hemostasis - Hypercoagulability - Formation of numerous fibrin monomers ```
Massive Coagulation System
30
what test is being performed when a reagent is sensitized with anti-fibrinogen antibodies?
thrombo-wellcotest
31
what is the sensitivity of thrombo-wellcotest?
up to 2 ug/mL
32
What enzyme is being added in the test in order for the inhibition of fibrinolytic system in vitro?
soy bean trypsin or soya bean enzyme
33
What is the resolution if the whole blood sample is extracted from heparinized patient in the thrombo-wellcotest?
reptilase enzyme
34
interpret this result: presence of agglutination in Well 1; none for the Well 2
FDP concentration of >10 ug/mL, but <40 ug/mL
35
interpret this result: lack of agglutination on both well
FDP concentration is <2 ug/mL
36
State 3 positive thrombo-wellcotest clinical association
DIC secondary fibrinolysis primary fibrinolysis postoperative Deep vein thrombosis Myocardial Infarction
37
what test is being performed when it needs an equal amounts of reagent and serum of patient
D-Dimer Test
38
What is the normal reference range of D-dimer in adults
less than 0.5 ug/mL
39
What laboratory procedures that detect soluble fibrin monomer
paracoagulation test
40
it is the most common paracoagulation test for screening disseminated intravascular coagulation
ethanol gelation test
41
what are the reagents used in screening for DIC?
95% ethanol | 0.1 N NaOH
42
A screening procedures that measure plasminogen activator concentration in the patient's plasma
Euglobulin lysis Time
43
What specimen is used for euglobulin lysis test
citrated platelet-poor plasma
44
What specimen is used in screening for DIC?
citrated platelet-poor plasma
45
interpet this result: if formed clot will lyse within 4 hours
normal plasminogen activator concentration
46
interpret this result: Complete lysis of clot in tube in less than 2 hours
increased plasminogen activator
47
interpret this result: complete lysis of the clot happens for >4 hours
decreased plasminogen activator
48
WHat reagent is responsible for clottign the CPPP in Factor XIII screening test
calcium chloride

Hematology (18 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions