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Hematology > Hema lec #7: Lab Evaluation of the fibrinolytic System > Flashcards

Hema lec #7: Lab Evaluation of the fibrinolytic System Flashcards

1
Q

Naturally occuring inhibitor that inhibits thrombon

A

Antithrombin III OR Heparin Cofactor I

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2
Q

It inhibits activated forms of IX, X XI XII, kallikrein, and plasmim

A

Antirhrombin III OR Heparin Cofactor I

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3
Q

Antithrombin III or Heparin Cofactor I supresses what system?

A

Coagulation and Fibrinolytic System

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4
Q

Heparin Cofactor III supresses what specific system?

A

Only supresses the coagulstion system

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5
Q

Protein C and Proten S regulstes coagulation system by inactivating …

A

Factor Va and Factor VIIIa

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6
Q

Onsay naka unique sa Tissue Factor Pathway Inhibitor

A

Bivalent Inhibitor — 1 molecules, inhibits 2 sites

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7
Q

What coagulstion factor that is being inhibited by TFPI

A

Factor Xa AND TF:VIIa

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8
Q

A quaternary complex that is calcium dependent due to vitamin K dependent

A

Xa:TF/VIIa:TF complex

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9
Q 
Aka Heparin Cofactor I
- Naturally-occurring inhibitor
- Inhibits activated forms of Factors XII, XI, X, IX, and
prothrombin
- Also inhibit plasmin and kallikrein
A

Antithrombin III

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10
Q

naturally occurring anticoagulant

A

Heparan sulfate

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11
Q

suppresses the Fibrinolytic System

A

Antithrombin III

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12
Q

T/F. Antithrombin III suppresses both coagulation and fibrinolytic
system

A

Truest

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13
Q

Only suppresses the coagulation system

A

Heparin Cofactor II

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14
Q
  • Vit. K dependent regulatory proteins
  • Regulates coagulation system by inactivating Factors Va
    and VIIIa
A

Protein C & S

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15
Q
  • Primary inhibitor of tPA
  • Inhibits u-PA
  • Produced by endothelial cells upon activation of
    bradykinin
  • Inactivated by APC, thrombin, and plasmin
A

PAI-1

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16
Q
  • Primary inhibitor of u-PA

- Found in placenta and macrophages

A

PAI-2

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17
Q

Primary inhibitor of Protein C

A

PAI-3

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18
Q

Removes lysine-binding sites from stable fibrin so

lys-plasminogen cannot bind to it

A

TAFI (Thrombin Activatable Fibrinolysis Inhibitor)

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19
Q

Inhibits free plasmin and plasmin liberated from the clot
- Primary inhibitor of plasmin once it has effectively
degraded clot

A

Alpha2-antiplasmin

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20
Q

Formation of fibrin monomer

A

Enzymatic

21
Q

Second line of defense in plasmin inhibition in

cases of pronounced fibrinolysis

A

Alpha2-macroglobulin

22
Q

Formation of insoluble fibrin

A

Stabilization

23
Q

Principle: Direct latex agglutination slide test
- Immunologic
- Involves antigen-antibody reaction
- Reagent is sensitized with anti-fibrinogen antibodies
(fragments D & E)
- antisera containing anti-fibrinogen antibodies directed
to Fragment D and E

A

Thrombo-Wellcotest

24
Q
  • Principle: Direct latex agglutination slide test
  • Reagents : antisera coated with monoclonal antibodies to the
    D-dimer
A

D-Dimer (D-DI Test)

25
Q

causes vasodilation to expose collagen

A

Prostacyclin

26
Q
  • Screening procedure for the measurement of
    fibrinolytic activity of the patient plasma
  • Measures plasminogen activator concentration in the
    patient’s plasma
A

Euglobulin Lysis Time

27
Q

Specimen of choice for ethanol gelation test

A

citrated platelet-poor

plasma

28
Q

Most common paracoagulation test for screening

disseminated intravascular coagulation

A

Ethanol Gelation Test

29
Q 
- Increased activity of the coagulation system, slower
fibrinolytic system
- Imbalance of hemostasis
- Hypercoagulability
- Formation of numerous fibrin monomers
A

Massive Coagulation System

30
Q

what test is being performed when a reagent is sensitized with anti-fibrinogen antibodies?

A

thrombo-wellcotest

31
Q

what is the sensitivity of thrombo-wellcotest?

A

up to 2 ug/mL

32
Q

What enzyme is being added in the test in order for the inhibition of fibrinolytic system in vitro?

A

soy bean trypsin or soya bean enzyme

33
Q

What is the resolution if the whole blood sample is extracted from heparinized patient in the thrombo-wellcotest?

A

reptilase enzyme

34
Q

interpret this result:

presence of agglutination in Well 1; none for the Well 2

A

FDP concentration of >10 ug/mL, but <40 ug/mL

35
Q

interpret this result:

lack of agglutination on both well

A

FDP concentration is <2 ug/mL

36
Q

State 3 positive thrombo-wellcotest clinical association

A

DIC secondary fibrinolysis
primary fibrinolysis
postoperative Deep vein thrombosis
Myocardial Infarction

37
Q

what test is being performed when it needs an equal amounts of reagent and serum of patient

A

D-Dimer Test

38
Q

What is the normal reference range of D-dimer in adults

A

less than 0.5 ug/mL

39
Q

What laboratory procedures that detect soluble fibrin monomer

A

paracoagulation test

40
Q

it is the most common paracoagulation test for screening disseminated intravascular coagulation

A

ethanol gelation test

41
Q

what are the reagents used in screening for DIC?

A

95% ethanol

0.1 N NaOH

42
Q

A screening procedures that measure plasminogen activator concentration in the patient’s plasma

A

Euglobulin lysis Time

43
Q

What specimen is used for euglobulin lysis test

A

citrated platelet-poor plasma

44
Q

What specimen is used in screening for DIC?

A

citrated platelet-poor plasma

45
Q

interpet this result:

if formed clot will lyse within 4 hours

A

normal plasminogen activator concentration

46
Q

interpret this result:

Complete lysis of clot in tube in less than 2 hours

A

increased plasminogen activator

47
Q

interpret this result:

complete lysis of the clot happens for >4 hours

A

decreased plasminogen activator

48
Q

WHat reagent is responsible for clottign the CPPP in Factor XIII screening test

A

calcium chloride

Hematology (18 decks)

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