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A/P > Lecture 1 > Flashcards

Lecture 1 Flashcards

Test 1

1
Q

What is anatomy?

A

The study of the structures and parts in living organisms

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2
Q

What are the 2 types of anatomy?

A

Gross - Visible with the eye
Microscopic - Needing a microscope to see

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3
Q

What is physiology?

A

The study of physical and chemical factors that are responsible for the origin, development, and progression of life

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3
Q

What is homeostasis?

A

Healthy conditions in the body that are maintained at near constant conditions to keep cells in good working order by using sensors and control mechanisms.

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4
Q

How many cells are in the body?

A

About 35 trillion

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5
Q

How many RBC are in the body?

A

About 25 trillion

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6
Q

Who coined the phrase regarding homeostasis in 1929?

A

Walter Cannon

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7
Q

What is the internal environment?

A

Extracellular fluid
Everything under the skin

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8
Q

According to homeostasis, what will happen if your internal temperature drops?

A

Your body will sense this and begin to shiver to bring your body temperature back up.

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9
Q

What happens when you’re paralyzed and your body temperature drops?

A

Your body loses the ability to shiver therefore you lose the control mechanism put in place to keep your body warm. Hence why we use bair huggers in the OR.

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10
Q

What goes in must equal…

A

what comes out

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11
Q

What is input?

A

Nutrients (food)

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12
Q

What is Output?

A

Energy and waste by-products

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13
Q

What is output energy?

A

Work, heat, potential energy

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14
Q

What are waste by-products?

A

CO2, protons, H2O, urea, solid waste

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15
Q

Why are sensors important in homeostasis?

A

They help to adjust for changing conditions; cannot adjust properly without functional sensors.

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16
Q

How does anesthesia effect the body’s ability to maintain homeostasis?

A

Anesthesia alters system physiology and removes the body’s sensory effects of the nervous system; CRNA does the work of the nervous system (work that usually the negative feedback response would do)

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17
Q

What happens around the cell when the cell metabolism increases?

A

The composition of the fluid around the cell changes to allow for nutrients to flow into the cell to maintain homeostasis.

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18
Q

What helps removes byproducts in the cardiovascular system?

A

Veins

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19
Q

What are the energy compounds cells need?

A

O2, sugars, fats, chemicals

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20
Q

How do the kidneys assist in homeostasis?

A

Maintains BP
ECF buffering for pH and electrolytes

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21
Q

How does the GI system assist in homeostasis?

A

Replaces nutrients in the blood being used/consumed by cells

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22
Q

How do the lungs assist in homeostasis?

A

Regulates blood gases

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23
Q

How do peripheral vascular beds assist in homeostasis?

A

The consist of arterioles, capillaries, and venules; which regulates blood flow to peripheral tissues and organs (vasoconstriction/vasodilation); nutrients and gas exchange; temperature; fluid balance; and waste removal.

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24
Q

How does the heart assist in homeostasis?

A

The heart consists of 2 pumps that share the septum wall. These pumps assist in gas exchange going into the lungs.

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25
Q

How does the liver assist in homeostasis?

A

The liver changes the chemical compositions of some substances into more useable forms; It also detoxifies or removes ingested chemicals into the bile to be excreted via feces.

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26
Q

What is Negative Feedback and how does it work?

A

It is a major control system in the body; Almost all systems are managed by this; changes are sensed and the body reacts to counter the change.

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27
Q

In Negative Feedback, the change is always ____________ to the stimuli.

A

Negative

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28
Q

What is the Negative Feedback response for increased CO2?

A

Increased ventilation to decrease CO2. This change is NEGATIVE to the stimuli.

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29
Q

What is the relationship between the PNS and the SNS?

A

They have opposite effects on the same organs to help maintain homeostasis.

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30
Q

What is the Negative Feedback change for a decreased MAP with SNS and PNS?

A

The NEGATIVE change is there is an increase in the SNS outflow and a decrease in the PNS outflow.

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31
Q

What is the Negative Feedback change for a decreased MAP with AVP/ADH?

A

Arginine Vasopressin and Antidiuretic hormone increase

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32
Q

What is the Negative Feedback change for a decreased MAP with ANP?

A

Atrial natriuretic peptide decreases

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33
Q

What is positive feedback and how does it work?

A

Stimuli causes a change in the body, with positive feedback, that change is amplified.

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34
Q

What are checkpoints in Positive feedback?

A

They are safety valves, which is a point to where the amplified change stops

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35
Q

What happens if the Positive Feedback response doesn’t stop at the checkpoint?

A

This is called a vicious cycle; can result in severe organ failure and/or death.

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36
Q

What is a vicious cycle?

A

It is when in positive feedback response continues and does not stop at the checkpoint.

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37
Q

What is the positive feedback response during labor and birthing?

A

Oxytocin-induced uterine contractions which is amplified to stretch the cervix and to have stronger contractions

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38
Q

What is the checkpoint for laboring?

A

Birth

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39
Q

What is the positive feedback response during a cut blood vessel?

A

Damaged endothelial cells liberate clotting factors and promote platelet plug formation and coagulation. This is amplified as time goes by.

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40
Q

What is the checkpoint for an injured blood vessel?

A

Bleeding stops

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41
Q

Describe the pathology of Positive Feedback in Severe Hemorrhage.

A

The loss of blood causes causes an initial drop in MAP and decreased coronary blood flow; which cause a decrease in cardiac output; which further decreases MAP

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42
Q

Describe the pathology of Positive Feedback in Sepsis/Necrosis.

A

The systemic infection causes cellular death; upon cellular death, the cells release byproducts into the ECF in which affect neighboring cells

43
Q

Describe the pathology of Positive Feedback in Severe Acidosis.

A

CNS is depressed which decreases respiratory drive; this worsens acidosis (pH decreases)

44
Q

Describe the pathology of Positive Feedback in Diabetic Renal Inflammation/Hyperfiltration.

A

Decrease in nephron regeneration can lead to renal failure d/t increasing workload on remaining nephrons

45
Q

Describe the pathology of Positive Feedback in Peripheral Acidotic conditions.

A

Cellular dysfunction, impaired blood flow, and reliance on anaerobic metabolism worsens acidosis.

46
Q

Describe the pathology of Positive Feedback in Atherosclerotic Plaque Clotting.

A

Overactive clotting cascade causes clot formation inside the surface of an atherosclerotic plaque in the coronary artery which causes MI.

47
Q

How many liters of blood is in the human body?

A

5 Liters

48
Q

What happens if you lose 1L of blood?

A

1L is 20% of your blood. Your body will go into compensated shock which will trigger a Negative Feedback response and you will recover.

49
Q

What happens if you lose 2L of blood?

A

2L id 40% of your blood. Your body will go into decompensated shock. Negative feedback is insufficient for this type of blood lose and positive feedback response. This vicious cycle will lead to death. Your body cannot recover from this without immediate interventions.

50
Q

What effects anesthesia response?

A

Physiological changes and/or comorbidities

51
Q

What is the smallest living unit?

A

A cell

52
Q

What is a cell?

A

The most basic functional unit; Specialize in specific tasks; Are able to create their own ATP via enzymatic machinery; Usually able to replicate

53
Q

What cells have difficulty replicating?

A

Neurons and heart cells; they replicate very slowly

54
Q

How do cells create ATP?

A

Enzymatic machinery

55
Q

What characteristic do lung cells have?

A

They are thin and narrow for gas exchange

56
Q

What do skin cells do?

A

Sheild from environmental factors

57
Q

What is Tissue comprised of?

A

Collection of cells

58
Q

What are organs comprised of?

A

Collection of tissues

59
Q

What is the body comprised of?

A

Collection of organs

60
Q

What is responsible for the maintenance of the entire body?

A

Organs

61
Q

Can RBC replicate?

A

No. RBC are produced by bone marrow progenitor stem cells

62
Q

What happens when a cell can’t self-replicate?

A

There’s a progenitor cell nearby to assist in replication

63
Q

What causes a cell to be unable to replicate?

A

Lack of nucleus; lack of DNA

64
Q

What allows cells to produce, divide, and replicate?

A

DNA (genetic makeup)

65
Q

How long to RBC live?

A

90 - 120 days

66
Q

What dictates the function of the cell?

A

DNA

67
Q

How much of a cell is water?

A

70-85%
With the exception of adipose cells

68
Q

What is the cytoplasm?

A

Everything inside the cell wall excluding the nucleus

69
Q

What is the cell membrane and what does it do?

A

“Cell wall” is a phospholipid bilayer that “keeps inside stuff in and outside stuff out”.

70
Q

Where do chemical reactions take place?

A

Cytoplasm

71
Q

What is the difference between ICF and the cytoplasm?

A

ICF is ONLY the fluid; the cytoplasm is everything inside the cell wall but not the nucleus. The cytoplasm includes ICF but they are not interchangable terms

72
Q

What is the function of a nucleus?

A

To pack and secure DNA from viruses and bacteria.

73
Q

Describe the nuclear membrane.

A

“Nucleus wall” is a double phospholipid bilayer. It is a very selective barrier.

74
Q

Why is the nuclear wall selective?

A

When other things get through such as viruses and bacteria; gene manipulation can happen and cause things such as cancer, HIV, etc

75
Q

What is the purpose of pores in the nuclear wall?

A

Pores allow transport from cytoplasm to inside nucleus.

76
Q

How do steroids work?

A

They go into the nucleus via pores and change gene transcription to turn on stress response proteins

77
Q

What is the endoplasmic reticulum?

A

“ER” It is an extension of the nuclear wall; produces fats and proteins; stores calcium in ER in muscles.

78
Q

Where is the endoplasmic reticulum?

A

It is an extension to the nuclear wall

79
Q

What are the different types of endoplasmic reticulum?

A

Granular (Rough) ER
Smooth ER

80
Q

What happens in the rough ER?

A

Ribosomes produce proteins from amino acids then are sent in transport vesicles to the Golgi apparatus

81
Q

What happens in the smooth endoplasmic reticulum?

A

fats/lipids are produced

82
Q

___% of ribosomes and protein translation are in the rough ER

A

95%

83
Q

___% of ribosomes and proteins are made in the cytosol

A

5%

84
Q

What does DNA do?

A

DNA genes encodes for protein and lipid synthesis in the rough and smooth ER

85
Q

What does the Golgi apparatus do?

A

It receives transport vesicles with proteins directly from the rough ER for post translational processing/modifications

86
Q

What does secretory vesicles do?

A

contains modified proteins from the Golgi apparatus that move towards and fuses to the the cell wall to be secreted outside the cell

87
Q

What does DNA mean?

A

Deoxyribonucleic acid

88
Q

What does RNA mean?

A

Ribonucleic acid

89
Q

What structure is a DNA?

A

Its a 3D structure that’s folded

90
Q

Can RNA pass through nuclear wall?

A

Yes

91
Q

-ase

A

enzyme proteins

92
Q

What is an enzyme?

A

A protein that catalyzes chemical reactions

93
Q

What is an organelle?

A

Internal specialized structure including lysosome, transport vesicles, mitochondria, and peroxisome

94
Q

What does peroxisomes do?

A

Use oxidative reactions to degrade toxins in the liver

95
Q

What does mitochondria assist in?

A

ATP production

96
Q

What do lysosomes do?

A

They use acidic conditions to degrade proteins, lipids, nucleic acids, and carbohydrates

97
Q

Glyco-

A

Sugar

98
Q

Carboxy-

A

Carb

99
Q

What produces ID tags?

A

Sugars and bacteria

100
Q

What is a special property of sugar?

A

Sugar is sticky and is stuck to a protein. Sugar groups can stick to each other and hold cells together.

101
Q

Why is the cytoplasm so important?

A

The chemical reactions that take place in the cytoplasm regulates acid/base balance and electrolytes

102
Q

Where are the sensors for feedback located?

A

In the periphery

103
Q

How many nephrons are in each kidney?

A

1 million

104
Q

Do nephrons regenerate?

A

No

105
Q
A

A/P (6 decks)

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