Lawsonia, Coxiella, Bartonella Flashcards
What characteristic of Lawsonia makes it difficult to grow?
Obligate intracellular- cannot be cultured in cell free media
What is the possible reservoir for Lawsonia
Wild animals
Where does Lawsonia infect? What does it do there? What species causes what disease and in what organisms
Intestinal epithelial cells and causes the enterocytes to proliferate which thickens the intestine mucosa which causes watery diarrhea Proliferative enteropathy (aka wet tail) caused by bacterium L. Intracellularis Occurs in pigs, foals, hamsters, rabbits usually stress induced
What is the transmission of Lawsonia
Fecal oral, but may remain viable outside of host cell for 2 weeks
Coxiella burnetti Replicates where
In host’s monocytes, macrophages, and trophoblast cells- called obligate intracellular bacterium
Transmission of Coxiella burnetti
Inhalation of aerosols or contaminated dust primarily or ingestion of placental tissue, milk, urine, feces
Or transmitted by ticks
Main source of Coxiella burnetti
Domestic ruminants
Coxiella burnetti’s primary target in host
Trophoblast cells of placenta
Coxiella burnetti clinical disease and how common it is and how it presents
Infection is common but disease is rare, Disease is Coxiellosis in animals and Q (Query) Fever in people
It presents as abortion in sheep and goats
Reportable disease
Is Coxiella burnetti zoonotic
Yes- aerosol transmission or consumption of raw milk
What is Bartonella considered and what does it infect
Facultative intracellular bacterium of RBCs and endothelial cells
Transmission of Bartonella
insect vector, fleas commonly
Clinical disease of Bartonella, what is it, what does it infect, and is infection/disease common
Bartonellosis caused by Bartonella henselae and infection of cats is common but disease is rare. Dogs not as commonly infected and more likely to show symptoms like fever, seizures, weight loss, endocarditis, enlarged lymph nodes
causes cat scratch disease in humans
Bartonellosis diagnosis, treatment, and prevention
Can culture from blood or PCR or serologic assays, treat with long term antibiotics but may not eliminate infection, prevent with flea and tick control
Bartonellosis zoonotic?
Yes- cat scratch disease from cats nails having infected flea feces on them from scratching at themselves
Causes vesicular skin lesions and lymph node enlargement
