L9 - 4.1 B cell development Flashcards
1
Q
why are B cell important
A
- specific to one antigen or target
- differentiate into plasma or memory cells
- produces antibodies fro portection
2
Q
ways for the antibodies binding to an AG
A
-neutralisation
-opsonisation
complement activation like promoting inflamm
3
Q
where are B cells made in in a foetus
A
liver
4
Q
where are B cell made in adults
A
bone marrow
5
Q
life stages of B cells
A
- rearranges its genes in bone marrow
- if immature B cell bind to self antigen, they die
- the B cell can get activtaed if bound to foreign AG
- then differentiate into memory and plasma cells
6
Q
steps of B cell devlopment
A
- pro B cell
rearranging genes for heavy chains
-then for diveristy and joining genes
-then for variety genes - this is now pre B cell where they now arrange light chain genes
- most of the time the gene rearrangemts are successful so they fail but if they succeed, immature b cells are form ed
7
Q
what is allelic exclusion
A
when one chromosome is used for rearrangment of the genes for B cell
8
Q
where does B cell develop on
A
on stromal cell in the bone marrow
-as they develop, they migrate from the subendostratum to the central axis
9
Q
what to do with a b cell that recongises self antigen
A
apoptosis or edit the receptors
10
Q
what do immature B cell express
A
surface IgM
11
Q
what do mature B cell express
A
surface IgM and IgD
