8.2 HPV

Question 1

what is HPV

Answer 1

skin lesions

Question 2

subfamilies of HPV

Answer 2

alpha, beta, gamma, herpesrivnae

Question 3

genometype of the HPV

Answer 3

linear ds DNA virus

Question 4

structure of HPV

Answer 4

has glycoproteins - in the lipid envelope for receptor mediated entry into the cells

tegument - viral matrix containing viral proteins for gene expiression

• has capsid containing the DNA

Question 5

example of aplha HPV and what cell does it affect

Answer 5

HSV-1

-affects mucoepithelial cells

Question 6

example of beta HPV and its target cells

Answer 6

CMV

- all cells ecxept t and b cells

Question 7

example of gamma HPV and its target cells

Answer 7

EBV

epithelilal cells and b cells

Question 8

two parts of the viral life cycle

Answer 8

lytic cycle

and latency

Question 9

what is lytic cycle

Answer 9

where the viral DNA replicates and makes viral proteins

- this activates the IS

Question 10

what is latency

Answer 10

no viral protein expression

• doesnt activate IS
• mechanism to evade the adaptive IS

Question 11

types of glycoproteins to help with HPV entry into cells

Answer 11

gB

, gH, gL

Question 12

pathway of the lytic cycle of the HPV in the host cell

Answer 12

1. entry
2. shuts down host cell’s defences using tegument proteins
3. viral replication of the components to make the virus
4. assembly and envelopment of the virus
5. release of the virus

Question 13

what components are made in the viral replication insdei of the host nucleaus

Answer 13

• immediate early proteins from the viral genome
• used them to make early proteins fro transcription of the viral genes
• uses early proteins to make viral DNA
• the viral DNA used to make the virus

Question 14

eg of early viral proteins

Answer 14

polyermase
-helicase
DNa PROCESSING FACTOR

Question 15

eg of late viral proteins

Answer 15

gH. gB, gL

tegument

Question 16

HSV-1 infection in what locations and what does it lead to

Answer 16

musocal surfaces for primary infection

• reactivates in the mouth or genital mucosa then travels to brain
  leads to destruction of the brain

Question 17

two unique properties of HSV

Answer 17

neurovirulence - replicate in the CNS

Latency - in the gangelions

Question 18

3 properties of latent infections

Answer 18

• viral products that helps with the repilcation arent made
• cells containing the latent genomes > not recogniseed by the IS
• the genome persists to create new infections

Question 19

how is the latent genomes preserved in the cells

Answer 19

• latency in mitotic cells
• mixes the viral DNA with the cells’s chromosomes
• latency in stem cells where it get activated during cell differentitation