8.2 HPV Flashcards
what is HPV
skin lesions
subfamilies of HPV
alpha, beta, gamma, herpesrivnae
genometype of the HPV
linear ds DNA virus
structure of HPV
has glycoproteins - in the lipid envelope for receptor mediated entry into the cells
tegument - viral matrix containing viral proteins for gene expiression
- has capsid containing the DNA
example of aplha HPV and what cell does it affect
HSV-1
-affects mucoepithelial cells
example of beta HPV and its target cells
CMV
- all cells ecxept t and b cells
example of gamma HPV and its target cells
EBV
epithelilal cells and b cells
two parts of the viral life cycle
lytic cycle
and latency
what is lytic cycle
where the viral DNA replicates and makes viral proteins
- this activates the IS
what is latency
no viral protein expression
- doesnt activate IS
- mechanism to evade the adaptive IS
types of glycoproteins to help with HPV entry into cells
gB
, gH, gL
pathway of the lytic cycle of the HPV in the host cell
- entry
- shuts down host cell’s defences using tegument proteins
- viral replication of the components to make the virus
- assembly and envelopment of the virus
- release of the virus
what components are made in the viral replication insdei of the host nucleaus
- immediate early proteins from the viral genome
- used them to make early proteins fro transcription of the viral genes
- uses early proteins to make viral DNA
- the viral DNA used to make the virus
eg of early viral proteins
polyermase
-helicase
DNa PROCESSING FACTOR
eg of late viral proteins
gH. gB, gL
tegument
HSV-1 infection in what locations and what does it lead to
musocal surfaces for primary infection
- reactivates in the mouth or genital mucosa then travels to brain
leads to destruction of the brain
two unique properties of HSV
neurovirulence - replicate in the CNS
Latency - in the gangelions
3 properties of latent infections
- viral products that helps with the repilcation arent made
- cells containing the latent genomes > not recogniseed by the IS
- the genome persists to create new infections
how is the latent genomes preserved in the cells
- latency in mitotic cells
- mixes the viral DNA with the cells’s chromosomes
- latency in stem cells where it get activated during cell differentitation
