4.3 - functions of ABs Flashcards
class of immunoglobin classes
IgM, IgD, IgG, IgE, IgA
what happens to the conc of IgG in primary and sec responses as time goes on
it increase over a few weeks
what part of the anitgen does the AB bind to
epitope
ways for AB to interact with AG on the pathogen
neutralisation
opsoninsation
complement activation
how does neutralisation work when there is a virus entry
- the AB binds to the virus receptors so the virus doesnt bind to the cell and inject its DNA
how does neutralisation work when there is a BACTERIAL INFECTION
AB binds to the bacterial adhesions on its surface so it doesnt bind to the receptors on the cell
how does neutralisation work when there is a toxin
AB blocks the toxin receptors
3 diff pathways int the complement activation
- lectin, classical and alternative
- they all generate C3 convertase and releases C3a
conseq of events after activating the complement activaiton
- C3a and C5a recruit phag cells to the site of infection and inflamm
- phagocytes with C3b receptors destroy the pathogen
- forms membrane attack complex which attacks the cell membrane and cause cell lysis
in opsonistion, what receptors can AB interact with
Fcreceptors
- FcR
what is opsonisation
immune process which uses opsonins to tag foreign pathogens for elimination by phagocyte
what receptor and antibody are present on the MAST cell
Fce receptor I and IgE AB
what does resting mast cell contain
- contains granules
- histamine and other inflamm mediators
what happens when a MAST cell is activated
released granules
- cross links between antigen and IgE antibody
how does NK cell kill the infected cell with the help fo ABs
- AB bind to the AG
- NK ‘s FcR recognise the AB bound
- signals NK to kill the ecll by apoptosis
