L3.3 - activation and expansion of T cells

Question 1

what are naive t cells

Answer 1

one that is matured but havent been activiated byt the antigen

Question 2

two things that naive t cells needs to do to become effector T cells

Answer 2

• need to proliferate to become specific to the AG -

- differentiation to provide effector function

Question 3

role of dendritic cell regarding t cell

Answer 3

activates T cells

Question 4

process of T cell getting activated by the dendrictic cell

Answer 4

• tissue dendritic cell takes in AGs and travel to the lymph node
• the AGA passed on to resident dendritic cell
• T cell in the lymph node activated by the antigen processing from the dendritic cell
• the T cell proliferate and dofferentiate before leaving the node

Question 5

types signals presented to the T cell during the AG presenting

Answer 5

1. activation - MHC interacts with the t cell receptor
2. survival - amppligy the signal by binding more to T cell receptor
3. Differentiation - stimulated by the cytokines and interleukins

Question 6

stages of T cell response

Answer 6

Naive> effector> memory if not, apoptotic

Question 7

sites of infections

Answer 7

extracell- interstitial spaces, blood, epithelial surfaces

intracell- cytoplasmic, vesicular

Question 8

types of effector T cells

Answer 8

CD8 cytooxic 
-CD4 TH1
-CD4TH2
CD4TH17
T helper cell 
CD4 regul cells

Question 9

function fo CDTH1 and its differentiation stimulated by what

Answer 9

activates infected macrophages to control infection by increasing MHC

• helps B cell for AB production
• by IL-12 and release inteferon gamma

Question 10

function fo CDTH2 and its differentiation stimulated by what

Answer 10

• helps B cell for AB production
• stimulated by IL-4
• promotes resistance to parasites

Question 11

function fo CDTH17 and its differentiation stimulated by what

Answer 11

• enchance neutrophil response
• promotes barrier intergity
• by IL-1B, IL-6, IL-21
• protect against fingal infection
• increases neutrophil count

Question 12

function fo T helper cell and its differentiation stimulated by what

Answer 12

• help B cell
• isotype switching
• turn of CCR7 and turn on CXCRS to allow the T cell to migrate to B cell

Question 13

function of CD4 reg cells

Answer 13

supress T cell response

• dervived from thymus and peripheral
• stimulated by the presense by TGFB