L57 Flashcards
Fungus that hyphae, pseduo-hyphae and budding morphologies - “yeast in the blood”
Candida
Fungi w/ germ tube morphology
Candida albicans
Fungi with branching, septa, and hyphae in structure - may also be cause of pneumonia in leukemia patients
Aspergillis
Which fungus has galacto-mannan its cell wall?
Aspergillus
What is the number RNA for fungus?
18s RNA
What are 3 unique molecules found in the fungi cell wall?
Beta-glucans
Mannans
Chitin = durability
What in a unique molecule in fungi cell membranes?
Ergosterol (not cholesterol aka whats in our cells)
What are the 4 taxonomy groups for fungi?
Zygomycetes = non-septate
Asconmycetes = simple septa
Basidiomycetes = elaborate septa
Deuteromycetes
What is classic dimorphism?
Grow as mold in the environment but as yeast in the body
Ex: Histoplasma capsulatum
What is the major exception to classic dimorphism?
Candida
Yeast in environment, hyphae in us
What 3 stains should know for fungi?
- H&E - shows there is something non-host
- PAS = periodic acid Schiff
- Fungal cell wall stain pink! - GMS - fungal cell wall stains silver, looks black/brown
What are spherule? What disease do they indicate?
= Large spheres w/ internal spores
Coccidioidomycosis (valley fever - think hiking in the southwest US)
What are the 4 types of fungal infections categorized by tissue involvement?
Superficial
Mucocutaneous
Subcutaneous
Deep
What is the example of superficial fungal infection? Inflammation present?
@ epidermis
No inflammation b/c haven’t reached skin layer that involves immune cells
TINA VERSICOLOR
- Skin scraping = spaghetti & meatballs
What is the example of mucocutaneous fungal infection?
@ epidermis + dermis Inflam b/c interaction w/ immune cells DERMATOPHYTOSIS - Itchy, painful - Papulosquamous eruption
