L34 Flashcards
1
Q
What is Selective toxicity? (magic bullet)
A
To kill microbial cells but not the hosts cells
2
Q
How does penicillin work?
A
Interfering with normal formation of bacterial cell wall
3
Q
How does antibiotic resistance occur?
A
Mutations of bacterial genome, which provides it advantage against antibiotics
4
Q
What is beta lactamase?
A
Enzyme expressed on plasmids which destroy penicillin
5
Q
How can beta lactamase plasmid be transferred between bacteria?
A
Horizontal and vertical gene transfer
6
Q
How to reduce antibiotic resistance
A
Decrease antibiotic use
Improve diagnostics
Identify new targets
Combination therapies
