L33 Flashcards
What is koch’s postulates
Guidelines used to demonstrate that a specific pathogen causes specific disease symptoms
What is the key stages of pathogenesis
- Adherence
- Invasion of host tissues
- Replication in host tissues
- Disease causing damage to host tissues
Adherence virulence factors
Use of fimbriae to bind to host
Invasion virulence factors
Motility (flagella)
Internalin related proteins
Replication virulence factors
Siderophores (Takes iron from surroundings)
Capsules (resist phagocytosis)
Disease virulence factors
Endotoxins: Cause inflammation
Exotoxins: Can be fatal
What are endotoxins
released when bacteria dies: Are Lipopolysaccharides which elicits strong immune reponse
Causes inflammation, fever, blood clot, shock
What are exotoxins and its 3 types
Produced in lliving bacteria then released into surrounding
Cytotoxins
Neurotoxins
Enterotoxins
What are cytotoxins
Lysis of red blood cells
What are neurotoxins
causes paralysis
Enderotoxins
Cause gastrointestinal damage