KE2 MDL Flashcards

1
Q

Eerste medicamenteuze stap bij zuurbranden

A

Antacidum of mucosaprotectiva

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2
Q

Werking antacidum

A

Zouten die direct het maagzuur neutraliseren; magnesiumhydroxide

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3
Q

Werking mucosaprotectiva

A

Vormen beschermlaag op maagslijmvlies; sucralfaat

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4
Q

Werking protonpompremmers

A

Remmen direct transport van H+ de maag in, door remming van H+/K+-uitwisselaar; pantoprazol

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5
Q

Werking antihistaminica (H2-receptor-antagonisten)

A

Remmen histamine gemedieerde stimulatie van maagzuurafgifte; famotidine

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6
Q

Bijwerkingen antacida

A

Obstipatie
Diarree

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7
Q

Typische bijwerking magnesiumhoudende antacida

A

Diarree

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8
Q

Typische bijwerking aluminium houdende antacida

A

Obstipatie

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9
Q

Tweede stap na antacida bij aanhoudende klachten

A

H2-antagonist > antihistaminica; famotidine
Na 2-4 weken

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10
Q

Welke receptor wordt geblokkeerd door famotidine

A

H2

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11
Q

Bij onvoldoende effect antacida en H2-receptor antagonist

A

PPI

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12
Q

Stappenplan maagklachten

A
  1. Antacida
  2. H2-receptor antagonist
  3. Protonpompremmer
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13
Q

Symptomen IBS

A

Terugkerende buikpijn
Veranderd ontlastingspatroon; diarree/obstipatie
Flatulentie
Meer klachten na de maaltijd
Minder klachten na toiletgang
Misselijkheid
Opgeblazen buik

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14
Q

Oorzaak IBS

A

Viscerale hypersensitiviteit;
Visceraal = darmregio

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15
Q

Ziekte van Crohn

A

In gehele maagdarmstelsel
Getriggerd door darmbacteriën

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16
Q

Behandeling ziekte van crohn

A

Ontstekingsremmers; corticosteroïden > prednison
Immunosuppressiva > azathioprine/methotrexaat
Biologicals; infliximab

17
Q

Behandeling CU

A

Aminosalicylaat; mesalazine
Corticosteroïden; prednison
Immunosuppresiva; azathioprine/methotrexaat