Interactions médicamenteuses Flashcards

1
Q

CYP1A2 - substrats

A

Clozapine

Théophylline

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2
Q

CYP1A2 - inhibiteurs

A
  • Ciprofloxacine
  • Enoxacine
  • Eluvoxacine
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3
Q

CYP1A2 - inducteurs

A

Fumée de tabac

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4
Q

CYP2C8 - substrats

A

Répaglinide

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5
Q

CYP2C8 - inhibiteurs

A

Gemfibrozil

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6
Q

CYP2C8 - inducteurs

A

ANTIEPILEPTIQUES : carbamazépine, phénobarbital, phénytoïne, oxcarbazépine

ANTIINFECTIEUX: rifampicine, rifabutine, griséofulvine

ANTIRETROVIRAUX : éfavirenz, névirapine

Modafinil

Millepertuis

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7
Q

CYP2C9 - substrats

A

Phénytoïne
Acénocoumarol
Carfarine

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8
Q

CYP2C9 - inhibiteurs

A

Amiodarone

Fluconazole

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9
Q

CYP2C9 - inducteurs

A

ANTIEPILEPTIQUES : carbamazépine, phénobarbital, phénytoïne, oxcarbazépine

ANTIINFECTIEUX: rifampicine, rifabutine, griséofulvine

ANTIRETROVIRAUX : éfavirenz, névirapine

Modafinil

Millepertuis

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10
Q

CYP2D6 - substrats

A

Tramadol, Codéine
Flécaïdine, Métoprolol
Propafénone

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11
Q

CYP2D6 - inhibiteurs

A

Fluoxétine
Paroxétine
Quindine

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12
Q

CYP2D6 - inducteurs

A

ANTIEPILEPTIQUES : carbamazépine, phénobarbital, phénytoïne, oxcarbazépine

ANTIINFECTIEUX: rifampicine, rifabutine, griséofulvine

ANTIRETROVIRAUX : éfavirenz, névirapine

Modafinil

Millepertuis²

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13
Q

CYP 3A4 - substrats

A

ANTI-CANCÉREUX : ITK, certains cytotoxiques

ANTI-PARASITAIRES : halofantrine, luméfantrine

BZD : midazolam, triazolam, zolpidem

DÉRIVÉS DE L’ERGOT DE SEIGLE : ergotamine, dihydroergotamine

IMMUNOSUPPRESSEURS : cyclosporine, sirolimus, tacrolimus

MORPHINIQUES: fentanyl, alfentanyl, méthadone, oxycodone

ŒSTROPROGESTATIFS ET PROGESTATIFS

STATINES : atorvastatine et simvastatine

ANTICOAGULANTS : apixaban, rivaroxaban

DIVERS: avanafil, vardénafil, pimozide, quindine, colchicine, carbamazépine

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14
Q

CYP3A4 - inhibiteurs

A

Antifongiques azolés (kétoconazole, ….)

Antirétroviraux ritonavir

Macrolides

Amiodarone

Dilatiazem

Vérapamil

Jus de pamplemousse

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15
Q

CYP3A4 - inducteurs

A

ANTIEPILEPTIQUES : carbamazépine, phénobarbital, phénytoïne, oxcarbazépine

ANTIINFECTIEUX: rifampicine, rifabutine, griséofulvine

ANTI-RETROVIRAUX : éfavirenz, névirapine

Modafinil

Millepertuis

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