inheritable tumours Flashcards
1
Q
in dogs
A
only 1
Renal carcinoma and nodular dermatofibrosis
2
Q
what breed is Renal carcinoma and nodular dermatofibrosis inheritable
A
german shepard
3
Q
mutation for Renal carcinoma and nodular dermatofibrosis
A
RCND gene
folliculin mutation
4
Q
in humans
A
birt - hogg - dubé syndrome
benign skin tumours
lung cysts
5
Q
mutation for birt- hogg
A
FLCN gene - folliculin mutation
6
Q
Human cancer predisposition genes found in germline DNA of dogs
A
BRCA1/BRCA2 –> breast cancer in humans
Mutation in dogs : not necessarily cause mammary cancer
TP53 –> Li-Fraumeni syndrome (several types of cancer) in humans
Mutation in dogs : occasionally cause cancer
7
Q
types of mutation
A
- Single Nucleotide Polymorphism (SNPs) : most common
- Copy number variation (CNVs)
- SNPs + CNVs (Combination of both)
8
Q
screening of tumours
A
- GWAS : genome-wide association studies
