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Med Micro Block 4 > Inflammatory Diarrhea > Flashcards

Inflammatory Diarrhea Flashcards

1
Q

Inflamm Diarrhea

A

Loose watery stools, smaller in volume plus PMNs; usually invasive infection of LI. Mucus and Blood present, abd cramps. (Occult blood = blood that’s not visible)

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2
Q

Dysentery

A

Inflammation of colon resulting in abd pain and cramps, straining stools with tenesmus. Watery diarrhea/loose stools containing PMNs, blood and mucus

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3
Q

Bacterial Path

A

Bacteria enter via endocytosis by M cells found in Peyer’s patches (SI) and migrate via lamina propria or cell to cell to LI or be endocytosed via cells w/in the lymphoid aggregates in LI.

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4
Q

Shigella Spp. Clin

A

Shigellosis/ Bacillary Dysentery/ Inflamm Diarrhea - large volumes diarrhea progressing to small volume with blood and tenesmus. May develop shallow intestinal ulcers. Alters Electrolyte balance

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5
Q

Shigella Spp. Char

A

Gram neg rod, four groups : Sonnei, Dysenteria, Flexneri, Bovdii. S and D most prevelent

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6
Q

Shigella Spp. Res

A

Humans only

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7
Q

Shigella Spp. Trans

A

Fecal Oral

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8
Q

Shigella Spp. RF

A

Pediatric; close quarters

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9
Q

Shigella Spp. Diag

A

Hektoen agar - green colonies; lactose negative

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10
Q

Shigella Spp. Toxins

A
  1. ShET 1 and ShET 2 (chromosome and plasmid) = early watery diarrhea
  2. S. Dys serotype produces Shiga toxin (AB) which inhibs protein synth by inact 60s ribosome subunit, synergizes with LPS to produce inflamm cytokines causing dmg to endothelium lining blood vessels. Assoc with progression to HUS
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11
Q

Shigella Spp. Comp/Seq

A

HUS in children and Reactive arthritis in those with HLA-B27

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12
Q

Enteroinvasive E. Coli Clin

A

Inflamm Diarrhea

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13
Q

Enteroinvasive E. Coli Char

A

Gram neg rod

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14
Q

Enteroinvasive E. Coli VF

A

Rearranges host cell actin for intracell mvmt and cell to cell infection

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15
Q

Enteroinvasive E. Coli Res

A

Humans and Animals

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16
Q

Enteroinvasive E. Coli Trans

A

Fecal-Oral

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17
Q

Enteroinvasive E. Coli RF

A

Anyone; ground beef

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18
Q

Enteroinvasive E. Coli Diag

A

Lactose pos, indole pos

19
Q

Salmonella Enterica spp. Clin

A

Salmonellosis = Inflamm diarrhea, small volume diarrhea and occult blood

20
Q

Salmonella Enterica spp. VF

A
  1. SopE gene protein - increases cAMP

2. SopB gene protein - actin rearrangement; host cell invasion

21
Q

Salmonella Enterica spp. Res

A

Animals - poultry, dairy, reptiles

22
Q

Salmonella Enterica spp. Trans

A

Fecal Oral

23
Q

Salmonella Enterica spp. RF

A

Eggs

24
Q

Salmonella Enterica spp. Diag

A

Hektoen - black colonies via H2S, lactose neg

25
Q

Salmonella Enterica spp. Comp/Seq

A

Reactive Arthritis (HLA-B27)

26
Q

Campylobacter Jejuni Clin

A

Campylobacterosis = Inflamm Diarrhea (10+per day)

27
Q

Campylobacter Jejuni Char

A

Gram neg comma shaped rod

28
Q

Campylobacter Jejuni Res

A

Animals - poultry, pets, human carries

29
Q

Campylobacter Jejuni RF

A

young and Icomp; unpasteurized milk

30
Q

Campylobacter Jejuni Diag

A

Culture at 42C

31
Q

Campylobacter Jejuni Seq/Comp

A 
Gullian-Barre Syndrome - ascending flaccid paralysis
Reactive Arthritis (HLA-B27)
32
Q

Yersinia Enterocolitica Clin

A

Inflamm diarrhea +/- blood

33
Q

Yersinia Enterocolitica Char

A

gram neg rod w/ bipolar staining

34
Q

Yersinia Enterocolitica Res

A

Animals, milk, pork, pets, chitlins

35
Q

Yersinia Enterocolitica Trans

A

Fecal Oral, transfusions

36
Q

Yersinia Enterocolitica RF

A

Dairy, pork, serious disease seen primarily in children

37
Q

Yersinia Enterocolitica Diag

A

Grow at 4C

38
Q

Yersinia Enterocolitica Comp/Seq

A
  1. Mesenteric lymphadentitis/pseudoappendicitis in adolescents/young adults
  2. Reactive Arthritis (HLA-B27)
  3. Bacteremia can occur with progression of disease or if infection is transmitted through transfusion
39
Q

Entameoba Histolytica Clin

A

Amoebiasis = Amoebic dysentery - Inflamm diarrhea with blood. Serious Disease leads to ulceration of LI (flask shaped lesions) and liver abscesses (RUQ pain)

40
Q

Entameoba Histolytica Char

A

Ameoboid protozoan

41
Q

Entameoba Histolytica Res

A

Human carriers; cysts can survive in soil and water

42
Q

Entameoba Histolytica Trans

A

Fecal Oral

43
Q

Entameoba Histolytica Diag

A

Cysts or motile trophozoites (visualized engulfed RBCs help) in stool. Followed by Elisa assay for Ag

44
Q

Entameoba Histolytica Tx

A

Amebicides

Med Micro Block 4 (15 decks)

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