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Med Micro Block 4 > Hepatitis > Flashcards

Hepatitis Flashcards

1
Q

Clinical

A

Primary Acute phase= systemic = flu like (fever and myalgia)

Add’l = Jaundice, dark urine (bilirubinuria), light stools (decreased bile), itch, hepatosplenomegaly, increased AST and ALT

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2
Q

Flaviviridae: Yellow Fever Virus Clin

A

Hepatitis. Mild to severe (GI hemo and black emesis). Progression to include infection of kidneys and liver (likes fixed macrophages)

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3
Q

Flaviviridae: Yellow Fever Virus char

A

ss pos sense RNA virus; enveloped

Infects dendritic cells, macrophages, monocytes and hepatocytes

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4
Q

Flaviviridae: Yellow Fever Virus Res

A

Animals

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5
Q

Flaviviridae: Yellow Fever Virus RF

A

Unvccn travelers to SAfrica and SAmerica

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6
Q

Flaviviridae: Yellow Fever Virus Trans

A

Mosquitos

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7
Q

Flaviviridae: Yellow Fever Virus Diag

A

Serology

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8
Q

Flaviviridae: Yellow Fever Virus Vccn

A

Live attenuated

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9
Q

Leptospira Interogens Clinical

A

Leptospirosis. Asymp to mild hepatitis. May progress to severe hemorrhagic disease.

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10
Q

Leptospira Interogens Char

A

Gram neg spirochete with bent ends

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11
Q

Leptospira Interogens VF

A

Hyaluronidase

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12
Q

Leptospira Interogens Res

A

Animals; survive in water/soil up to 3 months

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13
Q

Leptospira Interogens Trans

A

Direct/Indirect

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14
Q

Leptospira Interogens RF

A

Exposure to animal urine and water sports

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15
Q

Leptospira Interogens Diag

A

Paired sera; darkfield microscopy; PCR; Elisa; Agglutination

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16
Q

Leptospira Interogens Prvt

A

Rodent Control

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17
Q

Leptospira Interogens Comp/Seq

A

Well’s disease = Kid fail (increased creatinine)

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18
Q

Viral Cytopathology HAV and HEV

A

Both lack an envelope; stable in enviro (fecal oral). Cytopath = lytic so constantly provide extracell targets for IR. Generally no comp/seq or chronicity

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19
Q

Viral Cytopathology HBV and HCV

A

Both have envelope; not stable in enviro so body fluids required. Cytopath = budding and CTL/NK removal of infected cells. If inadequate IR = chronicity and clinical progression to cirrhosis and hepatocell carcinoma

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20
Q

Viral Cytopathology HDV

A

Defective virus; has an envelope. Can’t replicate w/o HBV

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21
Q

Picornaviridae: HAV Clin

A

Hepatitis. Enterically transmitted. IP=28 days. Dur = 2wks to 3 months. No chronic

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22
Q

Picornaviridae: HAV Char

A

ss pos sense RNA viruse non-env

23
Q

Picornaviridae: HAV trans

A

Fecal oral; low inf dose. Close personal contact: household, daycares; analingus. Contaminated food, drinking water: food handlers, raw shellfish, certain produce

24
Q

Picornaviridae: HAV RF

A

Unvccn

25
Q

Picornaviridae: HAV Diag

A

IgM = acute; IgG = post inf

26
Q

Picornaviridae: HAV Vccn

A

Inact and live attenuated (Ig passive for post exp)

27
Q

Hepeviridae: HEV Clin

A

Entericall trans hepatitis. IP - 40 days. Dur - 4 to 6 wks. Rare fulminating disease. Reactivation in immunocomp.

28
Q

Hepeviridae: HEV Char

A

ss pos sense RNA virus; non env

29
Q

Hepeviridae: HEV Res

A

Humans and animals

30
Q

Hepeviridae: HEV Trans

A

Fecal oral, some transplacental

31
Q

Hepeviridae: HEV RF

A

Shellfish, high mortality in third trimester preggo. Eastern and South Asia

32
Q

Hepeviridae: HEV Diag

A

Indistinguishable from Hep A. IgM for acute, IgG for post inf

33
Q

Hepadnaviridae: HBV Char

A

Partially ds circular DNA virus; enveloped

34
Q

Hepadnaviridae: HBV Res

A

Humans

35
Q

Hepadnaviridae: HBV Trans

A

Parental, sexual, perinatal

36
Q

Hepadnaviridae: HBV RF

A

Unvccn, IDU; neonates of chronic mother

37
Q

Hepadnaviridae: HBV Prvt

A

Recombinant vccn (subunit with s proteins), HBV IgG post/pre-exposure in aprop populations. Infant = active and passive immunizations w/in 12 hrs of birth

38
Q

Hepadnaviridae: HBV Clin

A

IP = 60 to 90 days. Hepatitis

39
Q

Hepadnaviridae: HBV Diag

A 
HBsAg - general marker of infection
HBsAb - documents recovery
HBcIgM - acute
HBcIgG - chronic
HBeAg - active replication, high trans
HBeAb - virus not rep, low trans
40
Q

Hepadnaviridae: HBV Window Period

A

both seromarkers HBsAg and Anti-HBs are neg because theyr are bound to each other. Other markers HBcIgM can be pos at this point.

41
Q

Hepatitis D Virus Clin 1

A

Coinfection with HBV. Acute disease similar to HBV alone or slightly more symptomatic. low risk of chronic infection

42
Q

Hepatitis D Virus Clin 2

A

Superinfection. On top of chronic HBV. Results in the most svr acute disease cases. Usually develop chronic HBV/HDV infection. High risk of liver failure.

43
Q

Hepatitis D Virus Char

A

Defective ss neg sense RNA virus; enveloped w/ HBsAg inserted

44
Q

Hepatitis D Virus Res

A

Humans

45
Q

Hepatitis D Virus Trans

A

Parenteral routes

46
Q

Hepatitis D Virus Diag

A

Serology - Total Ag

47
Q

Hepatitis D Virus Tx

A

Treat HBV

48
Q

Flaviviridae: HCV Clin

A

Hepatitis. Most new infections subclinical with 90% chronic leading to cirrhosis and heptocellular carcinoma

49
Q

Flaviviridae: HCV Char

A

ss pos sense RNA virus, enveloped; 6 genotypes

50
Q

Flaviviridae: HCV Res

A

Humans

51
Q

Flaviviridae: HCV Trans

A

Parenteral (decreased sexual; fetus)

52
Q

Flaviviridae: HCV RF

A

IDU, Tatoo, hemodialysis, use of blood products

53
Q

Flaviviridae: HCV Diag

A

Serology for total Ig; PCR

54
Q

Flaviviridae: HCV Tx

A

Pegylated IFN-alpha/ribavirin.

Telaprevir (protease inhib) which inhib rep

Med Micro Block 4 (15 decks)

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