Fevers of unknown origin - Infections of cell

Question 1

Herpesviridae EBV Clinical

Answer 1

Heterophilic mononucleosis with fever, sore throat, swollen lymph nodes. May have pharyngeal exudate, malaise for wks/mnths

Question 2

Herpesviridae EBV Char

Answer 2

dsDNA enveloped virus. Infects epi, salivary, lymphoid, and latent in B cells

Question 3

Herpesviridae EBV Res

Answer 3

Humans

Question 4

Herpesviridae EBV Trans

Answer 4

Resp droplets

Question 5

Herpesviridae EBV RF

Answer 5

Increased prevalence in teens, races and proliferative disease (lymphatics)

Question 6

Herpesviridae EBV Diag

Answer 6

Heterophile Abs pos, see downey cells (anti-immune cell T cells)

Question 7

Herpesviridae CMV Clin

Answer 7

Heterophile neg mononucleosis with fever, sore throat, swollen lymph nodes. No exudate, malaise for wks/months

Question 8

Herpesviridae CMV Char

Answer 8

dsDNA virus enveloped, beta group. Infects epi cells, salivary glands, monocytes, macrophages and fibroblasts (last 3 = latency)

Question 9

Herpesviridae CMV Trans

Answer 9

Resp and transplacental. Chronic in IComp

Question 10

Herpesviridae CMV Diag

Answer 10

Owl’s eye includions and basophilic intranuc inclusions. Heterophile negative

Question 11

Herpesviridae CMV Tx

Answer 11

Ganiclovir, foscarnet

Question 12

Herpesviridae CMV Comp/Seq

Answer 12

Cytomealytic Inclusion disease = In utero or react leading to jaundice, hepatosplenomegaly, purpura, pneumotitis

Question 13

Malaria

Answer 13

Is a FUO

Question 14

Ehrilichia Chaffcensis Clinical

Answer 14

Human monocytic Ehrilichiosis. Mild to severe body ache with fever and thrombocytopenia (low platlets)

Question 15

Ehrilichia Chaffcensis Char

Answer 15

Obligate Intracell microbe (Rickettsia Fam). Infects monocytes

Question 16

Ehrilichia Chaffcensis Diag

Answer 16

Too small to gram stain. Look for intracytoplasmic morulae

Question 17

Ehrilichia Chaffcensis Trans

Answer 17

Tick bite

Question 18

Ehrilichia Chaffcensis RF

Answer 18

Outdoors

Question 19

Anaplasma Phagocytophilum Clinical

Answer 19

Mild to severe body ache with fever and thrombocytopenia

Question 20

Anaplasma Phagocytophilum Char

Answer 20

Obligate Intracell microbe (Rickettsia Fam). Infects PMNs

Question 21

Anaplasma Phagocytophilum Diag

Answer 21

Intracytoplasmic morulae in Neutrophils

Question 22

Anaplasma Phagocytophilum Trans

Answer 22

Tick

Question 23

Flaviviridae: Dengue fever virus Char

Answer 23

ss pos sense RNA virus; enveloped; 4 serotypes
Infects monocytes, macrophages, B and T cells
Causes apoptosis of vasc endo cells

Question 24

Flaviviridae: Dengue fever virus Res

Answer 24

Humans, monkeys, mosquito (vector)

Question 25

Flaviviridae: Dengue fever virus RF

Answer 25

Anyone for Dengue Fever; previous exposure at increased risk for progression to DHF or DSS

Question 26

Flaviviridae: Dengue fever virus Diag

Answer 26

Serology (NS1 protein wk 1; Abs wk 2); PCR for type

Decreased WBCs and platlets with increased hematocrit are suggestive of plasma leakage (tourniquet test)

Question 27

Flaviviridae: Dengue fever virus ADE

Answer 27

Ag dependent enhancement: various Abs generated, upon secondary infection with other serotype, ABs bind less well and act to transport to phage and allow infection (non neut Abs)

Question 28

Flaviviridae: Dengue fever virus Clinical 1

Answer 28

Typical Uncomplicated fever - IP 1 wk, sudden onset of high fever, retroorbital pain, severe bone and joint pain, petechial rash. lasts 1 wk

Question 29

Flaviviridae: Dengue fever virus Clinical 2

Answer 29

DHF is DF and bleeding in nose, gums and under skin with petechia and purpura. Can lead to cytokine storm (viral elimination decreased but cytokines still increased.

Question 30

Flaviviridae: Dengue fever virus Clinical 3

Answer 30

DSS- DHS with fluid leak, massive bleeding and shock