FUO - Infections targeting vessels

Question 1

Togaviridae: Chikungunya Virus Clin

Answer 1

Chik/FUO with fever, HA, joint pain, petechia.

IP 3-12 days, flu symptoms, chills, edema, nausea, vomit

Question 2

Togaviridae: Chikungunya Virus Char

Answer 2

ss pos sense RNA virus enveloped

Infects endo cells, dendritic cells, macrophages, tissue

Question 3

Togaviridae: Chikungunya Virus Res

Answer 3

Humans and monkeys

Question 4

Togaviridae: Chikungunya Virus Trans

Answer 4

Mosquito bite

Question 5

Togaviridae: Chikungunya Virus RF

Answer 5

Travel to endemic area; africa, asia, india, st maarten

Question 6

Togaviridae: Chikungunya Virus Diag

Answer 6

Serology (RT-PCR for acute) - IgM/IgG

IFluor stain for blood smear

Question 7

Rickettsia Rickettsia Clin

Answer 7

Rocky mountain spotted fever. IP of 2-14 days. Triad of fever, HA, rash (3 to 5 days). Rash and edema starts at ankles and wrist and progresses to trunk, soles, palms, face. Can become gangrenous

Question 8

Rickettsia Rickettsia Char

Answer 8

Obligate intracell bacteria. small no gram stain. Intracytoplasmic inclusion bodies (morulae). Infects endothelial lining of small arteries, veins and caps

Question 9

Rickettsia Rickettsia Res

Answer 9

Animals

Question 10

Rickettsia Rickettsia Trans

Answer 10

tick

Question 11

Rickettsia Rickettsia Diag

Answer 11

History of tick bite, skin biopsy, PCR, clinical

Question 12

Rickettsia Rickettsia Tx

Answer 12

Doxycycline, start before confirmation