Inflammation + Repair 1

Question 1

Inflammation Pathways

Answer 1

vascular, cellular, coagulation, enzymes, chemical mediators

Question 2

Inflammation: Localized Signs

Answer 2

redness (rubor, erythema), heat (calor), swelling (tumor), pain (dolor), loss of normal tissue function

Question 3

Inflammation: Systemic Signs

Answer 3

fever, leukocytosis (wbc), elevated C-reactive proteins (liver), lymphadenopathy (swollen glands)

Question 4

WBC: Granular Cells

Answer 4

Neutrophils, Eosinophils, Basophils

Question 5

Neutrophils

Answer 5

60-70%, arrives 1st!, acute inflammation, phagocytosis

Question 6

Eosinophils

Answer 6

1-3%, allergy/parasitic infection

Question 7

Basophils

Answer 7

<1%, delayed allergic reactions

Question 8

WBC: Non-Granular Cells

Answer 8

Monocytes, Macrophages Lymphocytes, Mast Cell

Question 9

Monocytes

Answer 9

3-8%, found in blood, phagocytosis, 2nd to arrive!

Question 10

Macrophages

Answer 10

3-8%, found in TISSUE, phagocytosis, 2nd to arrive!

Question 11

Lymphocytes

Answer 11

20-30%, B and T cells, chronic inflammation

Question 12

Mast Cell

Answer 12

connective tissue cell, contains histamine (asthma)

Question 13

Phagocytosis

Answer 13

cells ability to engulf/degrade bacteria/foreign bodies. lysosomal enzymes w/i cell digest bacteria *enhanced if antigen coated w antibody

Question 14

Inflammation Sequence of Events:

Answer 14

Injury>constriction>dilation>hyperemia>erythema/heat>permeability>plasma leaves>
^blood thickens>blood flow decrease>margination>pavementing(WBC)>
chemotaxis(excape)>exudate/edema>phagocytosis

Question 15

Abscess

Answer 15

collection of exudate [pus] in localized area

Question 16

Fistula

Answer 16

abnormal passage from abscess to body surface

Question 17

Biomedical Mediators of Inflammation

Answer 17

kinins, complement, clotting factors

Question 18

Kinins

Answer 18

plasma proteins,*early phases of inflam, increases dilation + permeability. brandykinin induces pain.

Question 19

Complement System

Answer 19

produces cascade of plasma proteins, enhances immune response + phagocytosis

Question 20

Lysosomal Enzymes

Answer 20

can be released by body or by pathogen.

Question 21

Pyrogens

Answer 21

cause fever. *systemic manifestation of inflammation

Question 22

Leukocytosis

Answer 22

increase in WBC *systemic manifestation of inflammation

Question 23

Cellulitis

Answer 23

diffuse spread of inflammation into tissues, can be life threatening. requires drainage + antibiotics