Inflammation and Repair

Question 1

What is increased blood flow that foods the capillary beds in the injured tissue?

Answer 1

hyperemia

Question 2

What is a passage through the tissue which allows the excess exudate to drain?

Answer 2

fistula

Question 3

What is a surgical procedure for the removal of the excessive exudate?

Answer 3

incision and drainage

Question 4

What are 5 vasoactive factors?

Answer 4

• histamine
• seratonin
• bradykinin
• LTs/PGs
• PAF

Question 5

What are 5 chemotactic factors?

Answer 5

• C5a
• LTB
• Formylated peptides
• Lymphokines
• Monokines

Question 6

What cellular substances further inflammation and cause systemic effects like fever?

Answer 6

cytokine

Question 7

What cellular substances further inflammation and pain?

Answer 7

prostaglandins

Question 8

What cellular substances cause vasodilation and increased vascular permeability?

Answer 8

histamine

Question 9

What plasma substances increase in vascular permeability, attract inflammatory cells, and attack microorganisms?

Answer 9

complement

Question 10

What plasma substances increase in vascular permeability and cause pain?

Answer 10

kinins

Question 11

What plasma substance causes coagulation?

Answer 11

clotting

Question 12

Under what three conditions do you get resolution?

Answer 12

• the injury is limited or short lived
• there has been minimal tissue destruction
• the tissue is capable of regeneration

Question 13

Under what two conditions do you get scarring?

Answer 13

• inflammation affects tissues that cannot regenerate

- there has been substantial tissue destructiion

Question 14

When does abscess formation occur?

Answer 14

In the setting of certain pyogenic bacterial or fungal infections

Question 15

What three things is chronic inflammation characterized by?

Answer 15

• infiltration with mononuclear (“chronic inflammatory”) cells
• tissue destruction
• repair

Question 16

What’s another word for scarring?

Answer 16

Fibrosis

Question 17

In what kind of inflammation do mononuclear cells infiltrate with a proliferation of fibroblasts and new blood vessels?

Answer 17

non-specific inflammation

Question 18

What kind of inflammation is characterized by collections of activated macrophages called epitheloid cells surrounded by a rim o flymphocytes, +/- giant cells?

Answer 18

granulomatous inflammation

Question 19

_______ cells can be coaxed out of G0 stage.

Answer 19

Quiescent or stable

Question 20

_______ cells can not be coaxed out of G0 stage

Answer 20

Permanent

Question 21

______ cells are continuously cycling through the cell cycle

Answer 21

Labile

Question 22

Labile cells exist in what kinds of tissues?

Answer 22

• epidermis
• mucosa
• bone marrow
• lymphoid organs

Question 23

Stable cells exist in what kinds of tissues?

Answer 23

• liver
• proximal renal tubes
• endocrine glands
• endothelium

Question 24

Permanent cells exist in what kinds of tissues?

Answer 24

• neurons
• cardiac myocytes
• cells of the lens

Question 25

Most growth factors promote what two things?

Answer 25

• fibrosis

- angiogenesis

Question 26

_____ collagen is the principal collagen of bone, skin, and tendons, and the predominant collagen in mature scars.

Answer 26

Type I

Question 27

_____ collagen is the major collagen in cartilage.

Answer 27

Type II

Question 28

_______ collagen is found in basement membranes.

Answer 28

Type V-XXII

Question 29

____ collagen is found exclusively in basement membranes.

Answer 29

Type IV

Question 30

______ collagen is abundant in embryonic tissues, blood vessels, uterus, and G.I. tract.

Answer 30

Type III