Inflammation and Repair Flashcards
What is increased blood flow that foods the capillary beds in the injured tissue?
hyperemia
What is a passage through the tissue which allows the excess exudate to drain?
fistula
What is a surgical procedure for the removal of the excessive exudate?
incision and drainage
What are 5 vasoactive factors?
- histamine
- seratonin
- bradykinin
- LTs/PGs
- PAF
What are 5 chemotactic factors?
- C5a
- LTB
- Formylated peptides
- Lymphokines
- Monokines
What cellular substances further inflammation and cause systemic effects like fever?
cytokine
What cellular substances further inflammation and pain?
prostaglandins
What cellular substances cause vasodilation and increased vascular permeability?
histamine
What plasma substances increase in vascular permeability, attract inflammatory cells, and attack microorganisms?
complement
What plasma substances increase in vascular permeability and cause pain?
kinins
What plasma substance causes coagulation?
clotting
Under what three conditions do you get resolution?
- the injury is limited or short lived
- there has been minimal tissue destruction
- the tissue is capable of regeneration
Under what two conditions do you get scarring?
- inflammation affects tissues that cannot regenerate
- there has been substantial tissue destructiion
When does abscess formation occur?
In the setting of certain pyogenic bacterial or fungal infections
What three things is chronic inflammation characterized by?
- infiltration with mononuclear (“chronic inflammatory”) cells
- tissue destruction
- repair
What’s another word for scarring?
Fibrosis
In what kind of inflammation do mononuclear cells infiltrate with a proliferation of fibroblasts and new blood vessels?
non-specific inflammation
What kind of inflammation is characterized by collections of activated macrophages called epitheloid cells surrounded by a rim o flymphocytes, +/- giant cells?
granulomatous inflammation
_______ cells can be coaxed out of G0 stage.
Quiescent or stable
_______ cells can not be coaxed out of G0 stage
Permanent
______ cells are continuously cycling through the cell cycle
Labile
Labile cells exist in what kinds of tissues?
- epidermis
- mucosa
- bone marrow
- lymphoid organs
Stable cells exist in what kinds of tissues?
- liver
- proximal renal tubes
- endocrine glands
- endothelium
Permanent cells exist in what kinds of tissues?
- neurons
- cardiac myocytes
- cells of the lens
Most growth factors promote what two things?
- fibrosis
- angiogenesis
_____ collagen is the principal collagen of bone, skin, and tendons, and the predominant collagen in mature scars.
Type I
_____ collagen is the major collagen in cartilage.
Type II
_______ collagen is found in basement membranes.
Type V-XXII
____ collagen is found exclusively in basement membranes.
Type IV
______ collagen is abundant in embryonic tissues, blood vessels, uterus, and G.I. tract.
Type III
