Hypersensitivity Flashcards
What is the natural defense system that is always present (first line of defense)?
innate immunity
What is the pathologic response to a variety of previous antigenic (foreign) substances?
adaptive immunity
What type of immunity involves B lymphocytes producing antibodies?
humoral adaptive immunity
What type of immunity involves T lymphocytes?
cellular adaptive immunity
What are the two types of lymphoid tissues?
- generative lymphoid organs
- peripheral lymphoid organs
What is involved in lymphocyte progenitor stem cell development?
generative lymphoid organs
What concentrates antigens/antigen-presenting cells/B and T lymphocytes?
peripheral lymphoid organs
True or False? T lymphocytes only bind to protein fragments (not free antigens)?
True
CD4 T cells bind to MHC class ___.
II
CD8 T cells bind to MHC class ___.
I
MHC peptides are produced by genes on _______.
The short arm of chromosome 6
What type of T cells help B cells to produce antibodies?
CD4 Helper T cells
What T cells directly kill virus-infected cells?
CD8 Cytotoxic T cells
What type of T cell secretes proinflammatory cytokines and are associated with cell-mediated (cytotoxicity) responses?
TH1
What type of T cells secrete interleukins and are associated with B cell activation/antibody release?
TH2
Stimulated _______ differentiate (mature) in bone marrow into plasma cells.
B cells
_____ are produced in thymus and bone marrow, arise from B and T cells, and do not require prior sensitization.
natural killer cells
Dendritic cells, macrophages, and B cells are all ________.
antigen-presenting cells
What is an immune response that leads to tissue injury/disease?
hypersensitivity
What are the antibody-mediated hypersensitivities?
Types I, II, and III
What hypersensitivities are cell-mediated?
Type IV
