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Pathology > Hypersensitivity > Flashcards

Hypersensitivity Flashcards

1
Q

What is the natural defense system that is always present (first line of defense)?

A

innate immunity

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2
Q

What is the pathologic response to a variety of previous antigenic (foreign) substances?

A

adaptive immunity

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3
Q

What type of immunity involves B lymphocytes producing antibodies?

A

humoral adaptive immunity

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4
Q

What type of immunity involves T lymphocytes?

A

cellular adaptive immunity

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5
Q

What are the two types of lymphoid tissues?

A
  • generative lymphoid organs

- peripheral lymphoid organs

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6
Q

What is involved in lymphocyte progenitor stem cell development?

A

generative lymphoid organs

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7
Q

What concentrates antigens/antigen-presenting cells/B and T lymphocytes?

A

peripheral lymphoid organs

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8
Q

True or False? T lymphocytes only bind to protein fragments (not free antigens)?

A

True

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9
Q

CD4 T cells bind to MHC class ___.

A

II

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10
Q

CD8 T cells bind to MHC class ___.

A

I

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11
Q

MHC peptides are produced by genes on _______.

A

The short arm of chromosome 6

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12
Q

What type of T cells help B cells to produce antibodies?

A

CD4 Helper T cells

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13
Q

What T cells directly kill virus-infected cells?

A

CD8 Cytotoxic T cells

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14
Q

What type of T cell secretes proinflammatory cytokines and are associated with cell-mediated (cytotoxicity) responses?

A

TH1

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15
Q

What type of T cells secrete interleukins and are associated with B cell activation/antibody release?

A

TH2

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16
Q

Stimulated _______ differentiate (mature) in bone marrow into plasma cells.

A

B cells

17
Q

_____ are produced in thymus and bone marrow, arise from B and T cells, and do not require prior sensitization.

A

natural killer cells

18
Q

Dendritic cells, macrophages, and B cells are all ________.

A

antigen-presenting cells

19
Q

What is an immune response that leads to tissue injury/disease?

A

hypersensitivity

20
Q

What are the antibody-mediated hypersensitivities?

A

Types I, II, and III

21
Q

What hypersensitivities are cell-mediated?

A

Type IV

Pathology (17 decks)

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