Infectious Flashcards
Scarlet fever rash:
1. when it starts
2. from where it develop- the sequela of the rash
3. other menefistations
4. pathogen
- when it starts- 24-48 hrs **
2. from where it develop- **Groin and axilla and spread to trunk and extremity»_space; 3-4 days after the rush disaprre and the skin start to desquimation from face to bottom. , skin has Sand-like apperance - other menefistations- straberry tounge, exudate, red tonsilst, red uvula, post. platal patechial
- pathogen- GAS
Which types of GAS can cause RF?
M types, 1,3,5,6,18,29
Which ages of kids are at hish risk for RF?
5-15 yrs
Jones criteria - how we diagnose acute RF?
2 major or 1 minor or 1major + 2 minor
in all must be evidance of recent GAS infection
Recent infection- positive throat culture or RAPD / ALSO or Anti- DNAse B / antihyloronidase
What are the major critera of Jones?
J- Joint = migratory arthritis
O = Pancarditis
N = Nodules (subcutenous, mainly on joints)
E = Erythema marginatum
S = Syndheam chorea (could also present as cry/ lugher
What are the minor criteria of acute RF?
- Fever
- Arthralgia - only of no major Joint criteria
- CRP / ESR
- prolong PR- only if no major pancarditis criteria
Which Ab can be tested to proove GAS infection
Anti-DNAse B
Anti-strptolysin O
In which 3 situations we can diagnose acute RF without filling criterias?
- Syndheam Chorea is the only major criteria
- indolent Carditis in a pt coming monthes after disease
- reccurent RF in High risk populations
Tx for Acute RF with Syndenham chorea?
Penecillin + phenobarbital
How to prevent reccurent RF?
PPX penecillin G IM
until age 21 or until 40 if theres a valvular damage
w/o carditis- 5y or until 21 (the longest)
with carditis w/o residual disease- 10y or until 21
wth residual disease- 10y or 40 , consider for life
Tx for Acute RF?
- penecillin / amoxicillin PO 10 days or IM peneciilin one time
-
migratory polyarthritis or/with carditis- aspirin PO for several weeks
3.** caditis, cardiomegaly, heart failure-** Steroids
macrolide if theres an allergy to penecilin (azitromycin, clncamycin, erythromycin)
severe carditis- treat like HF
Which vaccinces are dead ones?
חיסון מומת
- Influenza IM
- HAV
- Polio IM
- Rabies
Which immunization contain recombinant products?
- HBV
- HPV
Which immunizations contain toxoids?
- diphteria
- tetanus
What is tha major advantage of conjuctudate vaccine vs polysaccharide one
חיסון מצומד לעומת פוליסכרידי
מוצמד = מוריד שיעור נשאות, מייצר נוגדנים עם אבידי גבוה יותר.
pnuemoccoc, Hib , hemingoccoc
When we will give HPV vaccine
11-12 yrs
2 doses
if immunocomprimesied / > 15yrs - 3 doses
Palivizumab is immunization against?
and what are the indications to give
RSV- in the start of brionchioles season
will be given to high risk pt:
1. neonate < 29wks until 1 yr old
2. Heart or lung condtions (congenital / nuromascular)- until 1 yrs old
3. BPD - until 1-2 yrs old
which Abx can be use ppx for meningoccoc exposure?
and when we will give ppx
1.Rifampin- 2Xday for 2d
2.Ceftriazone- one dose
3.Ciprofloxacin- one dose (age > 1 month)
7 days before onset for household, pre-school exposure, close contact, flight next to in flight > 8 hrs
PPx for tetanus after possible exposure?
- clean with soap and water
- vaccination (DTap, Tdap, Td) for - less then 3 doses or > 10 yrs since last shot
- Abs (TIG) for infected wound- with dirt, feces, soil, saliva in non-immunizations and HIV pt
TIG only given when immunization status is : uncertain or < 3 doses only in wound that is not clear and minor
PPx for rabies after possible exposure?
- wash with water and soap
- RIG (rabies Ab’s)- SC to the bite area
- 4 doses Rabies killed vaccine- at presentation to the ER»_space; 3d»_space; 7d»_space; 14d
when to treat for rabies from a home animal bite?
10days quarentine of the animal»_space; if the animal develops signs of rabies then start Tx.
What is the most commo cause of Severe bacterial infeciton in babies < 3 months?
UTI
Workout for toxic look baby (0-3 month) ?
- hospitalization
- empiric Tx
- full workout- labs, culture, urine, LP
- specific test (depends on presentation)- CXR, articulate puncture, stool culture
with fever
Empiric Abx for newborns until 2 moths of age
Ampicillin + Gentamycin
if sepsis or menengitis:
switch Gentamycin to Ceftriaxone (3rd generation)
Empiric Abx for 2-3 month of age with fever
Ceftriaxone
if pneumoccoc meningitis is suspect- add vanco
When we will empirically cover HSV?
- skin finding consist with HSV
- toxic baby with clinical suspect
- neurolohic symptoms - siezures, encephalitis, pleocytosis and mononuclears on CSF
Tx if Acyclovir IV 60mg/kg day devided to 3 doses
FUO definition
fever (38) > 8 days w/o source
How much time its take to drug fever to pass after medication is stopped?
around 72 hrs
which disease cause it?
how it spread?
Parvo B-19
slapped cheek
spread by droplet. start in face and then downwards
Fifth disease
which pathogen that present in adults in arthralgia and arthritis can cause in fetus Hydrops fetalis
Parvo-B19
Presentation of rubella?
Rash- from the face downwards (like measles but rubella disapper from head after 3 days not like measles)
Lymphadenopathy- Post. cervical, post, auricular, suboccipital
What is the congenital syndrome seen in rubella inf.
- deafness (sensrinural)
- bluberry muffin rash
- jaundice
- congenital cataract
- microencephaly
- Patent ductus arteriosus
What is the 6th disease?
which condition is higly a/w?
HHV6 (Roseola)
fever for 3-4 days»_space; then the fever fade an a rash show (diffuse rash w/o the face)
higly a/w febrile seziures
infected CD4 cells.
What are the 4 c’s of Measles?
Cough
Coryza (runny nose)
Conjuctuvitis
Koplik spots- bluish spots on buccal mucosa
What is the most common cause of death due to measles?
חצבת
pnuemonia (by virus imself or secondary to bacterial inf.)
SSPE (Subacute sclerosing panencephalitis) is a rare complication of which infection?
when it usally occure?
progressive demyelinating inflammation of the brain
measles
occur around 10 yrs after the disease
What is the chrecteristic of Measels rash
Start behind ears»_space; spread to face and neck»_space; sperad to entire body and merge + palms and soles
What are the complications of measles?
- Acute otitis media- most common
- pneumonia
- encephalitis
- black measels- detach of skin
- SSPE- late
Tx for Measels?
- Isoprinosine (anti-viral)- remission in 30-40%
- Carbamazepine (early myoclonus)
- vitamin A
Post exposure PPx for measles?
vaccine in 3 days or IVIG in 6 days
Hand and mouth disease?
Dx?
Coxsackievirus A16, Echovirus
Dx
virus culture- 50-75% sensetivity
PCR- more sensetive in less time
Which complication can be seen in Coxsackievirus infection??
Aspetic meningitis- mainly type A
Myocarditis- mainly B type
Dilatead Cardiomyopathy- mainly B type
devil’s grip (Bornholm disease)- unilateral pleuritic pain in lower chest»_space;> mainly B type
type A more common to see- the type causeing hand and mouth disease
When we will give Acyclovir for VZV infection?
immunosupression + unvacinated > 1 yr only if given 24 hrs from onset of rash
Complications of VZV?
- secondary bacterial skin infection - 5% of kids
- Reye syndrome- do not use Aspirin
- newborns- from mother
how can newborn get VZV infection and what is the Tx?
From mother- if she was sick 5 days prior the delivery to 2 days post delivery
must treat with VZIG
which CN is involve in Ramsay Hunt syndrome
CN VII
(VZV shingles)
פאציאליס ושלפוחיות בתעלת האוזן
What is the Tx for VZV shingles in kids and what its main benefit
acyclovir
accelerate recovery and reduce risk for post herpetic neuralgia
which CN is involve in lesions of VZV in mouth and cornea
CN V
Tx for impetigo
Abx ointment- Mupirocin or fusidic acid
Abx PO (rapidly involving inf. / reccurent / facial lesions) - Ceflaxine (1st generation)
Tx for Cellulitis
Ceflaxine or cefalozine PO (1st generation)
Tx for S. aureus folliculitis
Anti-septic Soap
if cont.»_space; Abx ointment
Which inf. a/w abcess in the follicular head 1-2 cm
Furuncle
S.aureus
Tx for furuncles?
Abx PO
driange- if abcess
mupiricon- if carrier in nostrils
What we need to check in a case of reccurent furunculosis?
S.aureus carrier (child or close family)
אבחון עם משטף אף
Which pathogen is a/w SSSS what is the Tx?
S. aureus»_space; Epidermolytic toxins
Tx
* IV penecillin + Clindamycin
* Supportive
risk for declie and sepsis
what is Paronychia?
whats the pathogen and Tx?
זיהום של שולי הציפורן, כסיסה, הגיינה יודה , מציצתאצבע
Acute- s. aureus
Chronic- Candida
Tx:
אמבטיית חיטוי
משחה אנטיביוטית
ניקוז- במוגלה
זיהום חום- אנטיובטיקה דרך הפה
What is the disease in each of the photos
from left to right
- impetigo- Abx ointment or Cephazolin PO
- cellulitis- Cephazolin / Cheplaxine PO
- folliculutus- anti-septal soap»_space; consider Abx ointment
S. aurues
Whays the main different between this two situations?
one is furuncle = abcess in follicule
other = Carbuncale = Abcess in few follicules and not single
S. aurues
What we see in each photo from left to right and clinical menefistation
- Erysipelas- superfical dermis, acute onset with fever
- Ecthyma- complication of impetigo by GAS, כיב עמוק מכוסה בגלד עבה
- Perianal dermatitis- sharp borders around anus, could cause pruritus. Daycare age
- Blistering Dactylitis- mainly schoolage kids.
GAS
What is the Tx for the following skin infections
1. Erysipelas
2. ecthyma
3. perianal dermatitis
4. Blistering dactylitis
- **Erysipelas- **Penecillin / Cefelozin PO (if severe penecillin IV)
- ecthyma- ריכוך והסרה + משחה אנטיובטית, קו 2 פניצלין דרך הפה
- perianal dermatitis- penecillin PO
- Blistering dactylitis- penecillin PO + drianege
Abx regimen for Necrotizing fascitis
Clindamycin + Cefotxime or Ceftriaxone
Which toxin is a/w TSS?
TSST-1 (s. aureus)
suprantigen
mainly by MSSA
What are the major criteria of Toxic shock syndrome
- fever > 38.3
- Hypotension
- rash- eventulay scalded
What is needed for Dgx of TSS?
3 major criteria + 3 minor criteria
major- fever, hyptension, rash
minor- mucositis, GI, Liver > X2, kidney > X2, muscle, CNS, PLT < 100
what are the 3 stages of skin in TSS
- rash
- healing- עור מתקלף, תוך 7-10 ימים
- הקרחה ואיבוד צפורנים- תוך חודשיים
Tx for TSS
- Clindamycin + naf/ oxacillin / cefazolin
- in severe- IVIG / setroids
- if MRSA susp. - Vanco
Which HSV is a/q genital ulcers?
HSV2
mor in womens
Ulcers in 6m-5y kids in the ant. mouth with lymphadenopathy and fever
Primary herpatic gingivostomatitis
self limiting, Acyclovir < 72h to shorten length of disease
What is Herpetic whitlow
herpes in finger of kids that sucking their fingers
Tx- PO acyclovir, reduce lengh and reccurent
Which medicatio is C/I in Herpes in the eye?
Steroids- can worse the infection
Whats the Dgx? Dentritic like lesion in eye exeminaiton?
Herpes in eye
יכול להגרום להצטלקות הקרנית עד לעיוורון
Which HSV is more a/w HSV encephalitis?
HSV-1
Tx for HSV enecephalitis, and what is the mortality rate w/o Tx?
IV acyclovir
w/o- 75% mortality
What are petrussis stages of ilness?
- incubation - 7-10 days
- caterral- 1-2 wks. coryza, fever low grade
- proxismal- 2-4wks, whooping cough»_space; vomiting
what are the red flags in whooping cough?
long episode > 45 sec
cyanosis
sat% not recover
non reaction to stimuli after vomiting
most common complication of whooping cough?
pneumonia- bacteria itself or pneumoccoc, strep, HIB
Test of choice for petrussis?
Nasopharynx PCR
Tx for petrussis?
Macrolides (azytromycin 5 dys)
Which Abx can cause Hyperthropic Pyloric stenosis in nwb < 14 days
Macrolides (mainly arythromycin)
PPx for family and close contact with petrussis?
5 days azytromycin for households and close contact
Tx for gonohrrea?
Ceftriaxone
+
Doxy / Azytromycin- clamydia
in dissaminated disease- hospitalizaiton + ceftriaxone IM + doxy/ azytromycin
What are the lesions seen in the 3 stages of shypilis?
- stage 1- Chancre - non painfuk
- stage 2- flu like + maculopappular rash + Condyloma lata
- Stage 3- Gummatous lesions
Tx after rape:
- Chepalosporin 3rd generation- genoccoc
- Azytromycin / doxy - Clamydia
- flagyl (metronidazole)- Thricomonas vaginalis and Bacterial vaginosis
- consider HIV PPx
Brucelosis Triad?
Fever + Hepatosplenomagalia + arthritis (sacroiilitis)
2-4 wks after infection
Which zoonotic disease menifest in sacroiliitis + Thrombocytopenia and eleveted liver enzymes?
Brucellosis
Dgx of brucellosis?
Blood culture- takes time (4 wks)
Rose bengel - agglutinaiton test
Tx for brucellosis?
below 8 yrs
Resprim (SMX-TMP) 4-8 wks + Rifampin 6 wks
above 8 yrs
Doxycycline 6 wks + Rifampin 6 wks / Sterptomycin / gentamycin 2 wks
What consider to be a complicated Brucellosis and what will be the Tx?
Meningitis, Endocarditis, Osteomylitis
Tx:
Doxycyclin + Rifampin + gentamycin
Mediteranean spotted fever
pathogen
Dgx
Tx
R. conorii
3-5 days after fever- maculopappular rash of involve hand and feets (like measles)
Dgx- Serology IgM eleveted
Tx- Doxy X2 for 7 days. if pregnant- Chlorompenicole
Tx same like murine thypus
Q-fever
patoghen
Triad + high clue sings in childrens
Dgx
Tx
patoghen- Coxiella brunetti (lice from cattle)
Triad + high clue sings in childrens- Triad- high fever, atypical pneumonia, hepatitis
in kids- osteomylitis which not repsnd to empiric tx
Dgx- IgM positive for phase 2 (in chronic- IgG positive for phase 1)
Tx- doxycycline
Most common pathogens for lymphadenitis?
painful + swollen LN
GAS
CMV
EBV
Satph
What are the indication for biopsy of lymphadenitis?
progressive growth within 2 weeks / no reduce in size in 4-6 weeks
Red flags- FUO, B symptoms, Supraclavicular LN, mediastinal mass
After how many days of no Tx response we will imaged a suspected LN?
after 1-2 days:
neck MRI/ US/ CT
What is the most common cause of regional chronic Lymphadenopathy
Cat scartch
What is the mosy common a-typical presentation in Cat scratch disease?
Parinaud oculoglandular syndrome
unilateral conjuctivitis + peri-ocular lymphadenopathy
Dgx and Tx for cat scratch
Dgx- clinical. can use serological / PCR testing as well
Tx- self limiting. Azytromycin after 30d to accelerate recovery
Which infection cause a unilateral non painful non motile LN»_space; becoming blue»_space; rupture and seen more in toddlers
Non TB mycobacterium
mainly MAC
Dgx- mentuo / IGRA
Tx- driange (Abx only if TB)
Which pathogen is a/w Ampiciliin rash?
EBV
A pt present with fever, exudative pharyngitis and lymphadenopathy
after administred ampicillin and rash is formed (shown in the picture)
what is most likley the pathogen
EBC
80%- ampicillin rash
50%- splenomegalia
10-20%- hepatomegalia
Which disease can be fatal to boys with Duncan disease
EBV
How to different primary inf. vs latent inf. in EBV
**primary- **EBV Early antigen positive,VCA-IgM positive,EBNA negetive
**latent- **EBNA + VCA-IgG
Retroparyngeal abcess:
Age
etiologies
Dgx
pathogens
age < 5 yrs
Etiologis- after URI or trauma
Pathogens- MRSA, MSSA, PAS, anerobes
Dgx- CT. culture from abcess- definite
Peri-tonsillar abcess:
Age
etiologies
Dgx
pathogens
age < adulcensts
Etiologis- after pharyngitis / tonsillitis
Pathogens- GAS and anerobes
Dgx- Clinical presenation + US
Tx for Peri-tonsillar abcess and Retropharyngeal abcess?
PTA- Amoxicillin- calvenulate / clyndamycin for 14 days
RPA- Ampicillin sulbactan, clindamycin, vanco-if MRSa susp.
Complications for Rtero-PA and Peri-tonsillar abcess?
- Airway obstruction
- Mediastinitis
- Aspiration pneumonia
- Lamierre synd- Jugular throboplhbitis
Which pathogen is mostly a/w Lemierre syndrome?
Fusobacterium
sending septic embolis to lungs from jugular thrombophlbitis
Ceftriaxone IV + I/D if abcess as necessary
Whats the Dgx?
Retropharyngeal abcess
What is the gold standart for GAS pharyngitis infection
Culture from לוע
90-95% sensetivity
Tx for GAS pharyngitis
- first line- penecillin / amoxicillin-calvinulate for 10 days *or penecillin G IM one time *
- mild sensetivity to penecillin- cehalaxine
- anapylaxis with penecillin- azytromycin or clindamycin
Clinical presenation of P-FAPA?
age of presentation, times of episodes
- Periodic Fever
- Aphtous somatitis
- Pharyngitis
- Adenitis
sporadic syndrome age 2-5y, every 8-12 times per year for 4-6 days
Tx for PFAPA?
Signle dose of presnisone / bethenazole
in severe cases- tonsillectomy
**disease itself is self limited withing 4-8yrs w/o any bad prognosis **
Which types of worms cause the night echiness?
and what is the Tx?
Anterobius vernmicularis (Pinworm- interstitial nematode)
Tx-Albendazole
Tx for peri-natal infection of HBV
HBIg + HBV vaccine
until 12 hrs from delivery
95% succsess.
no C/I for breastfeeding
What are the stages of chronic infection in HBV
- immune tolerant- no Tx. most kids
- immune active- most Tx in here, high ALT and liver fibrosis
- inactive phase- seroconversion- anti-HBe
- re-activation- in immunosuppresion pt
Which blood measurement is a good marker in HBV for the sevirty of demage and acute liver failure?
PT
Which HBV Ab is indication for seroconversion and recovery with low risk for infection others?
Anti-HBe
Pathogens of meningtitis in the following ages:
1. < 1 month
2. 1-3 month
3. > 3 month
and viruses
- < 1 month - GBS, E-coli, Lysteria
- 1-3 month- GBS. Pneumoccoc, Listeria
- > 3 months- pneumoccoc, meningoccoc
Viruses- Enteroviruses
paraechovirus
most a/pathogen of death from meningitis?
pnuemoccoc
Ampiric Tx for meningeitis in the following ages:
1. < 1month
2. > 1 month
-
< 1 month - Cefotaxime + Ampi + gentamycin
2.** > 1 month-** Cefotaxime / Ceftriaxome + Vancomycin + Steroids
most common cause of SBI (sys. bcterial inf.) in baby < 3 months
UTI
Indication for hospitalization in kids with UTI
- age < 2 month
- severe disease
- dehydration/ vomiting - things that challenge PO Tx
Tx for cystitis and Pyelonephritis
Cystitis- Cehalxine (cephoral) / Augmentin
Pyelonephritis- Cehalxine (cephoral) / Augmentin / Cefuroxime
main distinguish of pyelonephritis from cystitis?
pyelo- Fever
cystitis- צריבה דחיפות ותכיפות במתן שתן
most leading death infection in kidas < 5 yrs
pnuemonia
Tx for pneumonia in the following age groups:
1. age < 1 month
2. 1month - 5 yrs
3. age > 5 yrs
- < 1 month = hospitalizaiton + Ampicilin + gentamycin
- 1 month-5 yrs - Amoxiciliin (5-10 days) 2nd line- augmentin, cheplaosporin zinath or ceftriaxone IM
- age > 5 yrs- Azytromycin 3-5 days (macrolides) for atypical
לזכור טיפול בקהילה ב-2 המצבים הבאים:
1. מתחת לגיל 5- ניתן מוקסיפן ל-5-10 ימים
2. מעל גיל 5- ניתן אזניל (אזיתרומיצין) ל-3-5 מים
Fleuroquinolones are C/I in kids < 18
What is the definiton of reccurent pneumonia?
2 or more episodes in year or 3 or more episodes in life with normal imgaing btwn episodes
Otitis externa pathogens + Tx?
psuedomoans + S.arueus
Tx- Abx ointment (quinolones or polymyxin + steroids
רגישות במגע באפרכסת, כאב בלעיסה, הפרשה מהאוזן. ללא חום ללא פגיעה בשמיעה
swimmers ears
3 most common pathogens of acute otitis media
- Hib non typeable
- Pneumoccoc
- morexella catteralis
mainly co-infection with viruses (URTI)
mainly age group peak of Acute otitis media (AOM)
6-15 months
How to Dgx Otitis media?
- Autoscope- bulgeing and purelant effusion
- Tympanometry- acustic mesuremnt
- Acustic reflectometry- screeinig for AOM»_space; if pathologic »_space; Pneumatic otoscopy
- pneumatic otoscopy- evaluation of ear ventilation- very relable
What consider to be Reccurent AOM (acute otitis media)
> 3 episodes in 6 months or > 4 in 1 year.
considert Tympanostemy tube replacment
What are the complications of Otitis media?
- Chronic supportive Otitis media with > 6 wks of drainage Tympanic membrane perforated
- Mastoiditis
- Meningitis
- Cholesteatoma
- conductive hearing loss
- TM perforation
Tx for Otitis media
1st line- amoxicillin PO for 7 days
2nd line- augmentin (when resistant, 3 daysw/o improvment)
3rd ine- Cegtriaxone IM
drainage- severe or unresposive cases
in acute otiris media when Abx is not initially started
- 6-23 month baby with unilateral AOM w/o severe symptoms
- > 24 month old with unilateral or bi-lateral AOM w/o severe symptoms
watchful waiting for 48-72 hrs
Severe symptoms - fever > 39 or Otalgia (ear pain)
Tx forDgx of mastoiditis and Tx
Dgx- clinical presenation- OM signs + אפרכסת זקורה + CT to asses involvment of mastoid
Tx- Ceftriazome IV + surgical driange if abcess present
Coomon pathogens in bacterial sinusitis?
like Otitis media
Hib non-typable
morexella
pneumoccoc
What is the definition of acute, subacute and chronic sinusitis
acute < 30 d
sub-acute 31-90d
Chronic > 90d
when the following sinuses are openied
* Ethmoidal
* maxillary
* spenoidal
* frontal
- Ethmoidal- from birth
- maxillary- 4 y
- spenoidal- 5y
- frontal- 7-8y
Which 2 clinical presentation in adults with sinusitis are rare in childrens
כאבי ראש ורגישות בניקוש על פני הסינוסים
how to Dgx sinusitis and what is the defenite dgx way
Dgx by following criteria
1. גודש נזלת ושיעול > 10 ימים ללא שיפור
2. חום > 39 מעלות
3. נזלת מוגלתית מעל 3 ימים
4. סימנים מחמירים / נשנים לאחר שהיה כבר שיפור
Defintie Dgx- Sinus aspirate culture לא פרקטית ולא נעשית בשגרה
אבחנה קלינית
Tx for sinusitis
And what is the risk factors for resistance
first line and secondline and Tx for frontal sinusitis
50-60% self limiting
thus only Abx in severe cases
1. Amoxicillin 5-7d
2. augmentin (if risk factors for resistent to amoxiciliin) 7-10d
3. Frontal sinusitis- Ceftriaxone IV until improvment »_space; PO
risk factors for resistant-
* Abx in last 3 months
* daycare
* age < 2y
* no reposne after 72hrs
* co-morbidity
* immunodepression
What is Ondansetron?
when we will give and when its C/I and why
Anti-emesis medication for kids who vomiting
C/I- severe hydration»_space; can worsen diarrhea and prolong QT
what areth the indication of Abx in Gastroenteritis?
think about background but mainly pathogens
- age < 3 month
- co-morbidity
- dysenthera- fever, blood and WBC in stool
- Shigella- Azytromycin / Ceftriaxone PO
- ETEC/ EPEC- Azytromycin (azenyl)
- Vibrio colerae- Azytromycin
- C.difficile- in severe cases Metronidazole IV /PO + vancomycin PO / stool transplant
- Compylobacter- only if dysentria - Azytromycin
- Non-thypi salmonella- only in specific pt (immunocompremise)»_space; Ceftriaxone
- EHEC O157:H7 - Tx with Abx can cause HUS
Osteomylitis
age
bones
age < 5 yrs, more in boys
bones- lower leg»_space; Femur > tibia > humerus > fibula
Osteomylitis pathogens in newborns < 3 months
- S.aureus
- GBS
- E.coli
- Gram negetive
Osteomylitis in childrens > 3 months
- S.aureus
- pneumoccoc
- Kingella kingi
- GAS (can present with VZV)
- Salmonella - sickle cell
- coagulase negetive staph - cath. associated
Sexually active- think about Genoccocus
othes zoonotic- Brucella, Q-fever
Tx for osteomylitis
under age 3 month and above
under 3 month- Cefazolin + Gentamycin
above 3 month- Cefuroxime / Naficillin / Cefazolin
naf or oxacillin
Tx of brucelosis < 8 and > 8 yrs
age < 8 - resperim + Rifampin
age > 8 - doxy + Gentamycin / Rifampin
for Q fever- Rifampin/ Resperim/ Tetracyclins
Length of treatment in osteomylitis
3-4 weeks but can be up to 6 weeks
Septic arthritis,
most comoon joints + age
age < 3 , mainly boys
Most common joints- knee > hip > uncle
Dgx of septic arthritis
US- most sensetive
X-ray- follow bone healing
Articulocentesis- if suspect to be infected and accsable.
Empiric tx for septic arthritis.
which pathogens we want to cover
when we will need surgical drainage?
- S. aureus
- in little ones kingella 6-36 months
for both we can cover with cephazolin or vanco (if MRSA suspceted)
- Septic hip- emergency and need surgical drainage
in Septic Arthritis when we can cosider to change IV to PO therapy?
clinical improvment - no fever > 48 hrs, CRP decreasein 30-50%, negetive blood cultures
Rash + migratory arthritis
Acute RF