Infectious Flashcards
Scarlet fever rash:
1. when it starts
2. from where it develop- the sequela of the rash
3. other menefistations
4. pathogen
- when it starts- 24-48 hrs **
2. from where it develop- **Groin and axilla and spread to trunk and extremity»_space; 3-4 days after the rush disaprre and the skin start to desquimation from face to bottom. , skin has Sand-like apperance - other menefistations- straberry tounge, exudate, red tonsilst, red uvula, post. platal patechial
- pathogen- GAS
Which types of GAS can cause RF?
M types, 1,3,5,6,18,29
Which ages of kids are at hish risk for RF?
5-15 yrs
Jones criteria - how we diagnose acute RF?
2 major or 1 minor or 1major + 2 minor
in all must be evidance of recent GAS infection
Recent infection- positive throat culture or RAPD / ALSO or Anti- DNAse B / antihyloronidase
What are the major critera of Jones?
J- Joint = migratory arthritis
O = Pancarditis
N = Nodules (subcutenous, mainly on joints)
E = Erythema marginatum
S = Syndheam chorea (could also present as cry/ lugher
What are the minor criteria of acute RF?
- Fever
- Arthralgia - only of no major Joint criteria
- CRP / ESR
- prolong PR- only if no major pancarditis criteria
Which Ab can be tested to proove GAS infection
Anti-DNAse B
Anti-strptolysin O
In which 3 situations we can diagnose acute RF without filling criterias?
- Syndheam Chorea is the only major criteria
- indolent Carditis in a pt coming monthes after disease
- reccurent RF in High risk populations
Tx for Acute RF with Syndenham chorea?
Penecillin + phenobarbital
How to prevent reccurent RF?
PPX penecillin G IM
until age 21 or until 40 if theres a valvular damage
w/o carditis- 5y or until 21 (the longest)
with carditis w/o residual disease- 10y or until 21
wth residual disease- 10y or 40 , consider for life
Tx for Acute RF?
- penecillin / amoxicillin PO 10 days or IM peneciilin one time
-
migratory polyarthritis or/with carditis- aspirin PO for several weeks
3.** caditis, cardiomegaly, heart failure-** Steroids
macrolide if theres an allergy to penecilin (azitromycin, clncamycin, erythromycin)
severe carditis- treat like HF
Which vaccinces are dead ones?
חיסון מומת
- Influenza IM
- HAV
- Polio IM
- Rabies
Which immunization contain recombinant products?
- HBV
- HPV
Which immunizations contain toxoids?
- diphteria
- tetanus
What is tha major advantage of conjuctudate vaccine vs polysaccharide one
חיסון מצומד לעומת פוליסכרידי
מוצמד = מוריד שיעור נשאות, מייצר נוגדנים עם אבידי גבוה יותר.
pnuemoccoc, Hib , hemingoccoc
When we will give HPV vaccine
11-12 yrs
2 doses
if immunocomprimesied / > 15yrs - 3 doses
Palivizumab is immunization against?
and what are the indications to give
RSV- in the start of brionchioles season
will be given to high risk pt:
1. neonate < 29wks until 1 yr old
2. Heart or lung condtions (congenital / nuromascular)- until 1 yrs old
3. BPD - until 1-2 yrs old
which Abx can be use ppx for meningoccoc exposure?
and when we will give ppx
1.Rifampin- 2Xday for 2d
2.Ceftriazone- one dose
3.Ciprofloxacin- one dose (age > 1 month)
7 days before onset for household, pre-school exposure, close contact, flight next to in flight > 8 hrs
PPx for tetanus after possible exposure?
- clean with soap and water
- vaccination (DTap, Tdap, Td) for - less then 3 doses or > 10 yrs since last shot
- Abs (TIG) for infected wound- with dirt, feces, soil, saliva in non-immunizations and HIV pt
TIG only given when immunization status is : uncertain or < 3 doses only in wound that is not clear and minor
PPx for rabies after possible exposure?
- wash with water and soap
- RIG (rabies Ab’s)- SC to the bite area
- 4 doses Rabies killed vaccine- at presentation to the ER»_space; 3d»_space; 7d»_space; 14d
when to treat for rabies from a home animal bite?
10days quarentine of the animal»_space; if the animal develops signs of rabies then start Tx.
What is the most commo cause of Severe bacterial infeciton in babies < 3 months?
UTI
Workout for toxic look baby (0-3 month) ?
- hospitalization
- empiric Tx
- full workout- labs, culture, urine, LP
- specific test (depends on presentation)- CXR, articulate puncture, stool culture
with fever
Empiric Abx for newborns until 2 moths of age
Ampicillin + Gentamycin
if sepsis or menengitis:
switch Gentamycin to Ceftriaxone (3rd generation)
Empiric Abx for 2-3 month of age with fever
Ceftriaxone
if pneumoccoc meningitis is suspect- add vanco
When we will empirically cover HSV?
- skin finding consist with HSV
- toxic baby with clinical suspect
- neurolohic symptoms - siezures, encephalitis, pleocytosis and mononuclears on CSF
Tx if Acyclovir IV 60mg/kg day devided to 3 doses
FUO definition
fever (38) > 8 days w/o source
How much time its take to drug fever to pass after medication is stopped?
around 72 hrs
which disease cause it?
how it spread?
Parvo B-19
slapped cheek
spread by droplet. start in face and then downwards
Fifth disease
which pathogen that present in adults in arthralgia and arthritis can cause in fetus Hydrops fetalis
Parvo-B19
Presentation of rubella?
Rash- from the face downwards (like measles but rubella disapper from head after 3 days not like measles)
Lymphadenopathy- Post. cervical, post, auricular, suboccipital
What is the congenital syndrome seen in rubella inf.
- deafness (sensrinural)
- bluberry muffin rash
- jaundice
- congenital cataract
- microencephaly
- Patent ductus arteriosus
What is the 6th disease?
which condition is higly a/w?
HHV6 (Roseola)
fever for 3-4 days»_space; then the fever fade an a rash show (diffuse rash w/o the face)
higly a/w febrile seziures
infected CD4 cells.
What are the 4 c’s of Measles?
Cough
Coryza (runny nose)
Conjuctuvitis
Koplik spots- bluish spots on buccal mucosa
What is the most common cause of death due to measles?
חצבת
pnuemonia (by virus imself or secondary to bacterial inf.)
SSPE (Subacute sclerosing panencephalitis) is a rare complication of which infection?
when it usally occure?
progressive demyelinating inflammation of the brain
measles
occur around 10 yrs after the disease
What is the chrecteristic of Measels rash
Start behind ears»_space; spread to face and neck»_space; sperad to entire body and merge + palms and soles
What are the complications of measles?
- Acute otitis media- most common
- pneumonia
- encephalitis
- black measels- detach of skin
- SSPE- late
Tx for Measels?
- Isoprinosine (anti-viral)- remission in 30-40%
- Carbamazepine (early myoclonus)
- vitamin A
Post exposure PPx for measles?
vaccine in 3 days or IVIG in 6 days
Hand and mouth disease?
Dx?
Coxsackievirus A16, Echovirus
Dx
virus culture- 50-75% sensetivity
PCR- more sensetive in less time
Which complication can be seen in Coxsackievirus infection??
Aspetic meningitis- mainly type A
Myocarditis- mainly B type
Dilatead Cardiomyopathy- mainly B type
devil’s grip (Bornholm disease)- unilateral pleuritic pain in lower chest»_space;> mainly B type
type A more common to see- the type causeing hand and mouth disease
When we will give Acyclovir for VZV infection?
immunosupression + unvacinated > 1 yr only if given 24 hrs from onset of rash
Complications of VZV?
- secondary bacterial skin infection - 5% of kids
- Reye syndrome- do not use Aspirin
- newborns- from mother
how can newborn get VZV infection and what is the Tx?
From mother- if she was sick 5 days prior the delivery to 2 days post delivery
must treat with VZIG
which CN is involve in Ramsay Hunt syndrome
CN VII
(VZV shingles)
פאציאליס ושלפוחיות בתעלת האוזן
What is the Tx for VZV shingles in kids and what its main benefit
acyclovir
accelerate recovery and reduce risk for post herpetic neuralgia
which CN is involve in lesions of VZV in mouth and cornea
CN V
Tx for impetigo
Abx ointment- Mupirocin or fusidic acid
Abx PO (rapidly involving inf. / reccurent / facial lesions) - Ceflaxine (1st generation)
Tx for Cellulitis
Ceflaxine or cefalozine PO (1st generation)
Tx for S. aureus folliculitis
Anti-septic Soap
if cont.»_space; Abx ointment
Which inf. a/w abcess in the follicular head 1-2 cm
Furuncle
S.aureus
Tx for furuncles?
Abx PO
driange- if abcess
mupiricon- if carrier in nostrils
What we need to check in a case of reccurent furunculosis?
S.aureus carrier (child or close family)
אבחון עם משטף אף
Which pathogen is a/w SSSS what is the Tx?
S. aureus»_space; Epidermolytic toxins
Tx
* IV penecillin + Clindamycin
* Supportive
risk for declie and sepsis
what is Paronychia?
whats the pathogen and Tx?
זיהום של שולי הציפורן, כסיסה, הגיינה יודה , מציצתאצבע
Acute- s. aureus
Chronic- Candida
Tx:
אמבטיית חיטוי
משחה אנטיביוטית
ניקוז- במוגלה
זיהום חום- אנטיובטיקה דרך הפה
What is the disease in each of the photos
from left to right
- impetigo- Abx ointment or Cephazolin PO
- cellulitis- Cephazolin / Cheplaxine PO
- folliculutus- anti-septal soap»_space; consider Abx ointment
S. aurues
Whays the main different between this two situations?
one is furuncle = abcess in follicule
other = Carbuncale = Abcess in few follicules and not single
S. aurues
What we see in each photo from left to right and clinical menefistation
- Erysipelas- superfical dermis, acute onset with fever
- Ecthyma- complication of impetigo by GAS, כיב עמוק מכוסה בגלד עבה
- Perianal dermatitis- sharp borders around anus, could cause pruritus. Daycare age
- Blistering Dactylitis- mainly schoolage kids.
GAS
What is the Tx for the following skin infections
1. Erysipelas
2. ecthyma
3. perianal dermatitis
4. Blistering dactylitis
- **Erysipelas- **Penecillin / Cefelozin PO (if severe penecillin IV)
- ecthyma- ריכוך והסרה + משחה אנטיובטית, קו 2 פניצלין דרך הפה
- perianal dermatitis- penecillin PO
- Blistering dactylitis- penecillin PO + drianege
Abx regimen for Necrotizing fascitis
Clindamycin + Cefotxime or Ceftriaxone