Infections Flashcards
bacteria
- unicellular, do not require living tissue to survive.-
- rigid outer cell wall (gram + & - stain)
- semi permeable membrane, external slime layer and flagella
- capable of secreting toxins/enzymes
- replicate into spores (resistance to heat, disinfection, and other extremes
exotoxins
gram positive bacteria secrete exotoxins
endotoxins
found inside cell wall of gram negative bacteria
viruses
- small, obligate, intracellular parasites that require living cells for replication
- infection -> find cell + bind, inject itself into cell, uses nuclear machine to replicate using genetic material and than break cell (lysis) to get out
fungi
- ubiquitous (everywhere)
- growth promoted by warmth and moisture
- reproduce via spore production
- few are pathogenic
- fungi feed on sugar
- hard to kill
- cant all make you sick
- internal fungi infections are easier gotten by immune suppressed people
chlamydiae
- causes chlamydia
- it is a bacteria, very primitive (dinosaur bacteria).
- easy to treat
rickettsiae
- gram negative bacteria, intracellular parasites, need living cell to survive
- bacteria with cell wall but has viral properties
- vector (tick of mosquito) ex. lime disease
mycoplasma
- bacteria, no cell wall
- causes phemomnia
- hard to treat with antibiotics
protozoa
- parasite, complex organisms, like scabies
- can live independent, can jump from person to person.
helminths
parasite worms
resident flora
- generally doesn’t make us sick unless you are immune suppressed person, or you move it from its location.
Areas with Flora
skin, nasopharynx, colon, moth, rectum, vagina, perineum, distal rectum, urethra
Areas without Flora
blood, CSF, lungs, stomach, reproductive organs, bladder, kidney
Transmission of Infectious agents
- direct- mother to fetus, sexual transmission, direct contact
- indirect - involves intermitter ex. door knob is intermitter
- droplet - someone’s sneeze
- vector borne - vector required ex living creature
Host Resistance
increase risk factors: age (elderly and infants) malnutrition (protein) immune compromised transplant genetics stress diabetes corticosteroids foreign insertion burn victims break in skin
development of infection
- gain entry
- incubation (replication)
- prodromal period (malaise)
- acute period
- convalescence of chronic infection
septicemia
systemic infections - overwhelming, life threating infection
bactermia
organism into bloodstream
local signs of infection
swelling, redness, pain, swollen nodes (lymphadenopathy), purulent exudate
systemic signs of infection
fever, headache, leukocytosis (elevated WBC), chills, vomiting
Diagnostic Tests for infections
WBC count staining monocytosis (monocytes and neutrophils come to infection firsts - signs of new infection) C&S xray (pheumonia) septum sample
Treatments of Infections
- antibiotics - punctures cell wall
- antiviral - prevent replication
- antifungal - make it more permeable - fungal resemble own cells
- interferons - body made - secreted from infected cells which is a shield for other cells to protect them
tamaful
shortens virus time there fore decrease replication time
leukopenia
decreased WBC