Important Drugs Flashcards
Drugs having high first pass metabolism
LPG
Lignocaine
Propranolol
Glyceryl trinitrate (NTG)
Example of Drug which is not Bioequivalent
Phenytoin
Dialysis should be avoided in which drugs
AVOID Dialysis
Amphetamines
Verapamil
Opioids, Organophosphates
Imipramine
Digoxin
Diazepam (BZD)
Which group of drugs doesn’t cause Vomiting as a side effect
Antiemetics
Antipsychotics
Example of Prodrugs
All - ACE inhibitors (Exc: Capto and Lisinopril)
Prefer - PPIs
Doing - Dopamine
M - Minoxidil, Methyldopa, Mercaptopurine
D - Dipivefrine
In - Irinotecan
Clinical - Cyclophosphamide, Carbimazole, Clopidogre
Subjects - Sulfalsalzine
Enzyme Inducer drugs
G - Griseofulvin
P - Phenytoin
R - Rifampicin
S - Smoking
Cell - Carbamazepine
Phone - Phenobarbitone
Enzyme Inhibitor drugs
Vit - Valproate
K - Ketoconazole
Can’t - Cimetidine
Cause - Ciprofloxacin
Enzyme - Erythromycin
Inhibition - Isoniazid
Important Cytochrome enzymes
CYP3A4
CYP2D6
CYP2C9
CYP2C19
CYP1A1
Example of drugs metabolized by CYP3A4
C - Cyclosporine, CCB
T - Tacrolimus
S - Statins
C - CAT drugs
A - Amiodarone
N - NAVIRs
C - Cisapride
A - Astemizole
T - Terfanadine
Drugs metabolized by CYP2D6
Beta Blockers
Depression - Antidepressants
Antiarrhythmic drugs except Amiodarone
Drugs metabolized by CYP2C9
Phenytoin
Warfarin
Drugs metabolized by CYP2C9
Phenytoin
Warfarin
Drugs metabolized by CYP2C19
Clopidogrel
Drugs metabolized by CYP1A1/1A2
Acetaminophen
Drugs following Zero order Kinetics
Zero
W - Warfarin
A - Alocohol/Aspirin
T - Theophylline
T - Tolbutamide
Power - Phenytoin
Drugs following Zero order Kinetics
Zero
W - Warfarin
A - Alocohol/Aspirin
T - Theophylline
T - Tolbutamide
Power - Phenytoin
Drugs which binds on Inotropic receptors
GABA
Glutmate - NMDA, AMPA
Nn, Nm
5HT3
Drugs binding on Enzymatic receptors
Cytokines - IL, INF, TNF
Hormones - Prolactin , Insulin, GH
Drugs binding on Intracellular receptors
Corticosteroids
Vit D
Sex hormones
Vit A
T3, T4
TDM Should be done in which drugs
A - Aminoglycosides
Drug - Digoxin
Possesing - Phenytoin
Very - Valproate
Low - Lithium
Therapeutic - TCA
Index - Immunosuppressants
Important drugs causing Hemolytic anemia
Primaquine
Sulphonamides
Nitrofurantoin
Furazolidone
Drugs which are metabolized through Acetylation and can cause SLE like side effects
SHIP DRUGS
Sulphonamides
Hydralazine
Isoniazid
Procainamide
Example of Physiological antagonism
Adrenaline and Histamine
Example of Pharmacological Antagonism
Same receptors, different action
Prazosin and Adrenaline
Metoprolol and Adrenaline
Example of Synergism
Cotrimoxazole - Trimethoprim + Sulphamethoxazole
Example of Potentiation
Levodopa+ Carbidopa
