Important Drugs

Question 1

Drugs having high first pass metabolism

Answer 1

LPG
Lignocaine
Propranolol
Glyceryl trinitrate (NTG)

Question 2

Example of Drug which is not Bioequivalent

Answer 2

Phenytoin

Question 3

Dialysis should be avoided in which drugs

Answer 3

AVOID Dialysis
Amphetamines
Verapamil
Opioids, Organophosphates
Imipramine
Digoxin
Diazepam (BZD)

Question 4

Which group of drugs doesn’t cause Vomiting as a side effect

Answer 4

Antiemetics
Antipsychotics

Question 5

Example of Prodrugs

Answer 5

All - ACE inhibitors (Exc: Capto and Lisinopril)
Prefer - PPIs
Doing - Dopamine
M - Minoxidil, Methyldopa, Mercaptopurine
D - Dipivefrine
In - Irinotecan
Clinical - Cyclophosphamide, Carbimazole, Clopidogre
Subjects - Sulfalsalzine

Question 6

Enzyme Inducer drugs

Answer 6

G - Griseofulvin
P - Phenytoin
R - Rifampicin
S - Smoking
Cell - Carbamazepine
Phone - Phenobarbitone

Question 7

Enzyme Inhibitor drugs

Answer 7

Vit - Valproate
K - Ketoconazole
Can’t - Cimetidine
Cause - Ciprofloxacin
Enzyme - Erythromycin
Inhibition - Isoniazid

Question 8

Important Cytochrome enzymes

Answer 8

CYP3A4
CYP2D6
CYP2C9
CYP2C19
CYP1A1

Question 9

Example of drugs metabolized by CYP3A4

Answer 9

C - Cyclosporine, CCB
T - Tacrolimus
S - Statins
C - CAT drugs
A - Amiodarone
N - NAVIRs

C - Cisapride
A - Astemizole
T - Terfanadine

Question 10

Drugs metabolized by CYP2D6

Answer 10

Beta Blockers
Depression - Antidepressants
Antiarrhythmic drugs except Amiodarone

Question 11

Drugs metabolized by CYP2C9

Answer 11

Phenytoin
Warfarin

Question 12

Drugs metabolized by CYP2C9

Answer 12

Phenytoin
Warfarin

Question 13

Drugs metabolized by CYP2C19

Answer 13

Clopidogrel

Question 14

Drugs metabolized by CYP1A1/1A2

Answer 14

Acetaminophen

Question 15

Drugs following Zero order Kinetics

Answer 15

Zero
W - Warfarin
A - Alocohol/Aspirin
T - Theophylline
T - Tolbutamide
Power - Phenytoin

Question 15

Drugs following Zero order Kinetics

Answer 15

Zero
W - Warfarin
A - Alocohol/Aspirin
T - Theophylline
T - Tolbutamide
Power - Phenytoin

Question 16

Drugs which binds on Inotropic receptors

Answer 16

GABA
Glutmate - NMDA, AMPA
Nn, Nm
5HT3

Question 17

Drugs binding on Enzymatic receptors

Answer 17

Cytokines - IL, INF, TNF
Hormones - Prolactin , Insulin, GH

Question 18

Drugs binding on Intracellular receptors

Answer 18

Corticosteroids
Vit D
Sex hormones
Vit A
T3, T4

Question 19

TDM Should be done in which drugs

Answer 19

A - Aminoglycosides
Drug - Digoxin
Possesing - Phenytoin
Very - Valproate
Low - Lithium
Therapeutic - TCA
Index - Immunosuppressants

Question 20

Important drugs causing Hemolytic anemia

Answer 20

Primaquine
Sulphonamides
Nitrofurantoin
Furazolidone

Question 21

Drugs which are metabolized through Acetylation and can cause SLE like side effects

Answer 21

SHIP DRUGS
Sulphonamides
Hydralazine
Isoniazid
Procainamide

Question 22

Example of Physiological antagonism

Answer 22

Adrenaline and Histamine

Question 23

Example of Pharmacological Antagonism

Answer 23

Same receptors, different action
Prazosin and Adrenaline
Metoprolol and Adrenaline

Question 24

Example of Synergism

Answer 24

Cotrimoxazole - Trimethoprim + Sulphamethoxazole

Question 25

Example of Potentiation

Answer 25

Levodopa+ Carbidopa