GIT- Peptic Ulcer Disease

Question 1

Peptic ulcer is usually due to

Answer 1

Increased Hcl
Decreased defence mechanism

Question 2

Peptic ulcer is usually due to

Answer 2

Increased Hcl
Decreased defence mechanism

Question 3

Group of drugs that decreases acid secretion

Answer 3

M1 Blocker
H2 receptor blockers
PGE2
PPIs

Question 3

Group of drugs that decreases acid secretion

Answer 3

M1 Blocker
H2 receptor blockers
PGE2
PPIs

Question 4

M1 blockers used in treatment of Peptic ulcer disease

Answer 4

Pirenzepine
Telenzipine

Question 4

M1 blockers used in treatment of Peptic ulcer disease

Answer 4

Pirenzepine
Telenzipine

Question 5

H2 blockers used in treatment of PUD

Answer 5

Cimetidine
Ranitidine
Famotidine
Loxatidine
Nizatidine

Question 6

Characteristics 0f Cimetidine

Answer 6

Enzyme inhibitors (lot of drug interactions)
Gynaecomastia
Least potent
CNS side effects

Question 6

Characteristics 0f Cimetidine

Answer 6

Enzyme inhibitors (lot of drug interactions)
Gynaecomastia
Least potent
CNS side effects

Question 7

PGE2 Protects stomach from

Answer 7

Protects from Hcl by
Decreasing acid
Increasing mucus and Bicarbonate
Increases mucosal blood flow

Question 8

PGE2 Protects stomach from

Answer 8

Protects from Hcl by
Decreasing acid
Increasing mucus and Bicarbonate
Increases mucosal blood flow

Question 9

PGE2 used in PUD

Answer 9

Enprostil

Question 9

PGE2 used in PUD

Answer 9

Enprostil

Question 10

Misoprostol characteristics

Answer 10

PGE1 analogue
Can be used in NSAID induced Peptic ulcer
Contraindicated in pregnancy
Lot of Side effects

Question 10

Misoprostol characteristics

Answer 10

PGE1 analogue
Contraindicated in pregnancy
Lot of Side effects

Question 11

DOC in NSAID induced Peptic ulcer

Answer 11

PPI

Question 12

DOC in NSAID induced Peptic ulcer

Answer 12

PPI

Question 13

Proton pump inhibitors includes

Answer 13

Omeprazole
Esomeprazole
Pantoprazole
Lansoprazole
Dexlansoprazole
Rabeprazole

Question 14

PPIs are given as enteric coating label because

Answer 14

They are acid labile

Question 15

PPIs are drug of choice in

Answer 15

Peptic ulcer
GERD
Zollinger Ellison Syndrome

Question 16

Examples of Hit and run drugs

Answer 16

Aspirin
PPIs
MAO inhibitors

Question 17

Side effects of PPIs

Answer 17

Relatively safe
Carcinoid syndrome in rats seen
Calcium decrease - Osteoporosis
Vitamin B12 defeciency - Megaloblastic anemia when PPIs given for long time

Question 17

Side effects of PPIs

Answer 17

Relatively safe
Carcinoid syndrome in rats seen
Calcium decrease - Osteoporosis
Vitamin B12 defeciency - Megaloblastic anemia when PPIs given for long time

Question 18

Antacids used in PUD because

Answer 18

They neutralizes Hcl
To immediately prompt pain relief

Question 18

Antacids used in PUD because

Answer 18

They neutralizes Hcl To immediately prompt pain relief

Question 19

Antacids used in PUD

Answer 19

Mg(OH)2 - Fast but short acting Diarrhea as Side effect Al(OH)3 - Slow but long acting Constipation as side effect Usually given combined

Question 20

Ulcer protective drugs

Answer 20

Sucralfate Colloidal Bismuth Subcitrate(CBS)

Question 20

Ulcer protective drugs

Answer 20

Sucralfate Colloidal Bismuth Subcitrate(CBS)

Question 21

Sucralfate can polymerise when pH below

Answer 21

4 Don't give antacids with Sucralfate

Question 22

Sucralfate can polymerise when pH below

Answer 22

4 Don't give antacids with Sucralfate

Question 23

Colloidal Bismuth Subcitrate

Answer 23

Can kill H pylori Overdose - Bismuth Poisoning

Question 23

Colloidal Bismuth Subcitrate

Answer 23

Can kill H pylori Overdose - Bismuth Poisoning

Question 24

Effect of Bismuth Poisoning on bones and Brain

Answer 24

Bone - Osteodystrophy Brain - Encephalopathy

Question 24

Effect of Bismuth Poisoning on bones and Brain

Answer 24

Bone - Osteodystrophy Brain - Encephalopathy

Question 25

Antimicrobial agents used PPI to kill H pylori

Answer 25

Amoxicillin Clarithomycin Metronidazole

Question 25

Antimicrobial agents used PPI to kill H pylori

Answer 25

Amoxicillin Clarithomycin Metronidazole

Question 26

Triple drug therapy used in PUD

Answer 26

2 antimicrobials + 1 PPI for 2 weeks CAP - Clarithomycin + Amoxicillin+ PPI

Question 26

Triple drug therapy used in PUD

Answer 26

2 antimicrobials + 1 PPI for 2 weeks CAP - Clarithomycin + Amoxicillin+ PPI