GIT- Peptic Ulcer Disease Flashcards
Peptic ulcer is usually due to
Increased Hcl
Decreased defence mechanism
Peptic ulcer is usually due to
Increased Hcl
Decreased defence mechanism
Group of drugs that decreases acid secretion
M1 Blocker
H2 receptor blockers
PGE2
PPIs
Group of drugs that decreases acid secretion
M1 Blocker
H2 receptor blockers
PGE2
PPIs
M1 blockers used in treatment of Peptic ulcer disease
Pirenzepine
Telenzipine
M1 blockers used in treatment of Peptic ulcer disease
Pirenzepine
Telenzipine
H2 blockers used in treatment of PUD
Cimetidine
Ranitidine
Famotidine
Loxatidine
Nizatidine
Characteristics 0f Cimetidine
Enzyme inhibitors (lot of drug interactions)
Gynaecomastia
Least potent
CNS side effects
Characteristics 0f Cimetidine
Enzyme inhibitors (lot of drug interactions)
Gynaecomastia
Least potent
CNS side effects
PGE2 Protects stomach from
Protects from Hcl by
Decreasing acid
Increasing mucus and Bicarbonate
Increases mucosal blood flow
PGE2 Protects stomach from
Protects from Hcl by
Decreasing acid
Increasing mucus and Bicarbonate
Increases mucosal blood flow
PGE2 used in PUD
Enprostil
PGE2 used in PUD
Enprostil
Misoprostol characteristics
PGE1 analogue
Can be used in NSAID induced Peptic ulcer
Contraindicated in pregnancy
Lot of Side effects
Misoprostol characteristics
PGE1 analogue
Contraindicated in pregnancy
Lot of Side effects
DOC in NSAID induced Peptic ulcer
PPI
DOC in NSAID induced Peptic ulcer
PPI
Proton pump inhibitors includes
Omeprazole
Esomeprazole
Pantoprazole
Lansoprazole
Dexlansoprazole
Rabeprazole
PPIs are given as enteric coating label because
They are acid labile
PPIs are drug of choice in
Peptic ulcer
GERD
Zollinger Ellison Syndrome
Examples of Hit and run drugs
Aspirin
PPIs
MAO inhibitors
Side effects of PPIs
Relatively safe
Carcinoid syndrome in rats seen
Calcium decrease - Osteoporosis
Vitamin B12 defeciency - Megaloblastic anemia when PPIs given for long time
Side effects of PPIs
Relatively safe
Carcinoid syndrome in rats seen
Calcium decrease - Osteoporosis
Vitamin B12 defeciency - Megaloblastic anemia when PPIs given for long time
Antacids used in PUD because
They neutralizes Hcl
To immediately prompt pain relief
Antacids used in PUD because
They neutralizes Hcl
To immediately prompt pain relief
Antacids used in PUD
Mg(OH)2 - Fast but short acting
Diarrhea as Side effect
Al(OH)3 - Slow but long acting
Constipation as side effect
Usually given combined
Ulcer protective drugs
Sucralfate
Colloidal Bismuth Subcitrate(CBS)
Ulcer protective drugs
Sucralfate
Colloidal Bismuth Subcitrate(CBS)
Sucralfate can polymerise when pH below
4
Don’t give antacids with Sucralfate
Sucralfate can polymerise when pH below
4
Don’t give antacids with Sucralfate
Colloidal Bismuth Subcitrate
Can kill H pylori
Overdose - Bismuth Poisoning
Colloidal Bismuth Subcitrate
Can kill H pylori
Overdose - Bismuth Poisoning
Effect of Bismuth Poisoning on bones and Brain
Bone - Osteodystrophy
Brain - Encephalopathy
Effect of Bismuth Poisoning on bones and Brain
Bone - Osteodystrophy
Brain - Encephalopathy
Antimicrobial agents used PPI to kill H pylori
Amoxicillin
Clarithomycin
Metronidazole
Antimicrobial agents used PPI to kill H pylori
Amoxicillin
Clarithomycin
Metronidazole
Triple drug therapy used in PUD
2 antimicrobials + 1 PPI for 2 weeks
CAP - Clarithomycin + Amoxicillin+ PPI
Triple drug therapy used in PUD
2 antimicrobials + 1 PPI for 2 weeks
CAP - Clarithomycin + Amoxicillin+ PPI
