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Pharmacology > GIT- Peptic Ulcer Disease > Flashcards

GIT- Peptic Ulcer Disease Flashcards

1
Q

Peptic ulcer is usually due to

A

Increased Hcl
Decreased defence mechanism

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2
Q

Peptic ulcer is usually due to

A

Increased Hcl
Decreased defence mechanism

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3
Q

Group of drugs that decreases acid secretion

A

M1 Blocker
H2 receptor blockers
PGE2
PPIs

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3
Q

Group of drugs that decreases acid secretion

A

M1 Blocker
H2 receptor blockers
PGE2
PPIs

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4
Q

M1 blockers used in treatment of Peptic ulcer disease

A

Pirenzepine
Telenzipine

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4
Q

M1 blockers used in treatment of Peptic ulcer disease

A

Pirenzepine
Telenzipine

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5
Q

H2 blockers used in treatment of PUD

A

Cimetidine
Ranitidine
Famotidine
Loxatidine
Nizatidine

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6
Q

Characteristics 0f Cimetidine

A

Enzyme inhibitors (lot of drug interactions)
Gynaecomastia
Least potent
CNS side effects

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6
Q

Characteristics 0f Cimetidine

A

Enzyme inhibitors (lot of drug interactions)
Gynaecomastia
Least potent
CNS side effects

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7
Q

PGE2 Protects stomach from

A

Protects from Hcl by
Decreasing acid
Increasing mucus and Bicarbonate
Increases mucosal blood flow

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8
Q

PGE2 Protects stomach from

A

Protects from Hcl by
Decreasing acid
Increasing mucus and Bicarbonate
Increases mucosal blood flow

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9
Q

PGE2 used in PUD

A

Enprostil

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9
Q

PGE2 used in PUD

A

Enprostil

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10
Q

Misoprostol characteristics

A

PGE1 analogue
Can be used in NSAID induced Peptic ulcer
Contraindicated in pregnancy
Lot of Side effects

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10
Q

Misoprostol characteristics

A

PGE1 analogue
Contraindicated in pregnancy
Lot of Side effects

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11
Q

DOC in NSAID induced Peptic ulcer

A

PPI

12
Q

DOC in NSAID induced Peptic ulcer

A

PPI

13
Q

Proton pump inhibitors includes

A

Omeprazole
Esomeprazole
Pantoprazole
Lansoprazole
Dexlansoprazole
Rabeprazole

14
Q

PPIs are given as enteric coating label because

A

They are acid labile

15
Q

PPIs are drug of choice in

A

Peptic ulcer
GERD
Zollinger Ellison Syndrome

16
Q

Examples of Hit and run drugs

A

Aspirin
PPIs
MAO inhibitors

17
Q

Side effects of PPIs

A

Relatively safe
Carcinoid syndrome in rats seen
Calcium decrease - Osteoporosis
Vitamin B12 defeciency - Megaloblastic anemia when PPIs given for long time

17
Q

Side effects of PPIs

A

Relatively safe
Carcinoid syndrome in rats seen
Calcium decrease - Osteoporosis
Vitamin B12 defeciency - Megaloblastic anemia when PPIs given for long time

18
Q

Antacids used in PUD because

A

They neutralizes Hcl
To immediately prompt pain relief

18
Q

Antacids used in PUD because

A

They neutralizes Hcl
To immediately prompt pain relief

19
Q

Antacids used in PUD

A

Mg(OH)2 - Fast but short acting
Diarrhea as Side effect
Al(OH)3 - Slow but long acting
Constipation as side effect

Usually given combined

20
Q

Ulcer protective drugs

A

Sucralfate
Colloidal Bismuth Subcitrate(CBS)

20
Q

Ulcer protective drugs

A

Sucralfate
Colloidal Bismuth Subcitrate(CBS)

21
Q

Sucralfate can polymerise when pH below

A

4
Don’t give antacids with Sucralfate

22
Q

Sucralfate can polymerise when pH below

A

4
Don’t give antacids with Sucralfate

23
Q

Colloidal Bismuth Subcitrate

A

Can kill H pylori
Overdose - Bismuth Poisoning

23
Q

Colloidal Bismuth Subcitrate

A

Can kill H pylori
Overdose - Bismuth Poisoning

24
Q

Effect of Bismuth Poisoning on bones and Brain

A

Bone - Osteodystrophy
Brain - Encephalopathy

24
Q

Effect of Bismuth Poisoning on bones and Brain

A

Bone - Osteodystrophy
Brain - Encephalopathy

25
Q

Antimicrobial agents used PPI to kill H pylori

A

Amoxicillin
Clarithomycin
Metronidazole

25
Q

Antimicrobial agents used PPI to kill H pylori

A

Amoxicillin
Clarithomycin
Metronidazole

26
Q

Triple drug therapy used in PUD

A

2 antimicrobials + 1 PPI for 2 weeks

CAP - Clarithomycin + Amoxicillin+ PPI

26
Q

Triple drug therapy used in PUD

A

2 antimicrobials + 1 PPI for 2 weeks

CAP - Clarithomycin + Amoxicillin+ PPI

Pharmacology (14 decks)

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