Immunology Antibodies Clinical use

Question 1

Alemtuzumab

Answer 1

CLL

“ALYMtuzumab”: chronic LYMphocytic leukemia

Question 2

Bevacizumab

Answer 2

Colorectal cancer, renal cell carcinoma

Question 3

Cetuximab

Answer 3

Stage IV colorectal cancer, head and neck cancer

Question 4

Rituximab

Answer 4

B-cell non-Hodgkin lymphoma, RA (with MTX), ITP

Question 5

Trastuzumab

Answer 5

Breast cancer, gastric cancer

HER2 “tras2zumab”

Question 6

Infliximab, adalimumab

Answer 6

IBD, Rheumatoid arthritis, ankylosing sponydilitis, psoriasis. (PAIR HLA-B27 diseases except for Rheumatoid arthritis)
“RA “inflix” pain in “da limbs”

Question 7

Natalizumab

Answer 7

Multiple sclerosis, Crohn disease
alpha4-integrin: leukocyte adhesion.
Risk of PML in patients with JC virus

Question 8

Abciximab

Answer 8

Anti

IIb times IIIa equals “abSIXimab”

Question 9

Denosumab

Answer 9

Osteoporosis; inhibits osteoclast maturation (mimics osteoprotegrin)
“DenOSumab affects OSteoclasts”

Question 10

Digoxin immune Fab

Answer 10

Antidote for digoxin toxicity

Question 11

Omalizumab

Answer 11

Allergic asthma; prevents IgE binding to FcEpsilonRI

Question 12

Palivizumab

Answer 12

RSV PPx for high risk infants

PaliVIzumab: VIrus